Cover Image

CpG-free plasmids confer reduced inflammation and sustained pulmonary gene expression.

Pulmonary delivery of plasmid DNA (pDNA)/cationic liposome complexes is associated with an acute unmethylated CG dinucleotide (CpG)-mediated inflammatory response and brief duration of transgene expression. We demonstrate that retention of even a single CpG in pDNA is sufficient to elicit an inflamm...

Full description

Saved in:
Bibliographic Details
Main Authors: Hyde, Stephen C., Pringle, Ian A., Abdullah, Syahril, Lawton, Anna E., Davies, Lee A., Varathalingam, Anusha, Nunez-Alonso, Graciela A., Green, Anne Marie, Bazzani, Reto P., Sumner-Jones, Stephanie G., Chan, Mario, Hong, Yu Li, Yew, Nelson S., Cheng, Seng H., Boyd, Christopher A., Davies, Jane C., Griesenbach, Uta, Porteous, David John, Sheppard, David N., Munkonge, Felix M., Alton, Eric W. F. W., Gill, Deborah R.
Format: Article
Language:English
English
Published: Nature Publishing Group 2008
Online Access:http://psasir.upm.edu.my/id/eprint/13817/1/CpG.pdf
http://psasir.upm.edu.my/id/eprint/13817/
http://www.nature.com/nbt/index.html
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

http://psasir.upm.edu.my/id/eprint/13817/1/CpG.pdf
http://psasir.upm.edu.my/id/eprint/13817/
http://www.nature.com/nbt/index.html

Similar Items