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pH-Responsive Starch-Citrate Nanoparticles for Controlled Release of Paracetamol

Starch-citrate samples with degrees of substitution (DS) ranging from 0.11 to 0.90 are synthesized by a green esterification reaction between citric acid and native sago starch (Metroxylon sagu) in an aqueous medium. Starch-citrate nanoparticles with mean diameter of 105 nm are subsequently obtained...

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Main Authors: Chin, Suk Fun, Ain Nadirah, Romainor, Pang, Suh Cem, Lee, Book Kiat, Hwang, Siaw San
Format: Article
Language:English
Published: John Wiley & Sons, Inc 2019
Subjects:
QD Chemistry
Online Access:http://ir.unimas.my/id/eprint/46265/1/Chin%20et%20al.%2C%202019.pdf
http://ir.unimas.my/id/eprint/46265/
https://onlinelibrary.wiley.com/doi/abs/10.1002/star.201800336
https://doi.org/10.1002/star.201800336
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spelling my.unimas.ir-462652024-10-09T03:07:57Z http://ir.unimas.my/id/eprint/46265/ pH-Responsive Starch-Citrate Nanoparticles for Controlled Release of Paracetamol Chin, Suk Fun Ain Nadirah, Romainor Pang, Suh Cem Lee, Book Kiat Hwang, Siaw San QD Chemistry Starch-citrate samples with degrees of substitution (DS) ranging from 0.11 to 0.90 are synthesized by a green esterification reaction between citric acid and native sago starch (Metroxylon sagu) in an aqueous medium. Starch-citrate nanoparticles with mean diameter of 105 nm are subsequently obtained by controlled precipitation through drop-wise addition of dissolved starch-citrate solution into excess absolute ethanol. These nanoparticles are observed to exhibit pH-responsive release profiles within the physiological pH range of 1.2–8.6. The release profile of a model drug (paracetamol) is observed to obey the zero-order kinetics, with the release mechanism based on the diffusion and swelling model. The cytotoxicity study in HaCaT cell lines (human skin cells) shows that starch-citrate nanoparticles are non-toxic and hence are suitable for biomedical applications as pH-responsive drug carriers. John Wiley & Sons, Inc 2019 Article PeerReviewed text en http://ir.unimas.my/id/eprint/46265/1/Chin%20et%20al.%2C%202019.pdf Chin, Suk Fun and Ain Nadirah, Romainor and Pang, Suh Cem and Lee, Book Kiat and Hwang, Siaw San (2019) pH-Responsive Starch-Citrate Nanoparticles for Controlled Release of Paracetamol. Starch, 71 (9-10). pp. 1-33. ISSN 1521-379X https://onlinelibrary.wiley.com/doi/abs/10.1002/star.201800336 https://doi.org/10.1002/star.201800336
institution Universiti Malaysia Sarawak
building Centre for Academic Information Services (CAIS)
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sarawak
content_source UNIMAS Institutional Repository
url_provider http://ir.unimas.my/
language English
topic QD Chemistry
spellingShingle QD Chemistry
Chin, Suk Fun
Ain Nadirah, Romainor
Pang, Suh Cem
Lee, Book Kiat
Hwang, Siaw San
pH-Responsive Starch-Citrate Nanoparticles for Controlled Release of Paracetamol
description Starch-citrate samples with degrees of substitution (DS) ranging from 0.11 to 0.90 are synthesized by a green esterification reaction between citric acid and native sago starch (Metroxylon sagu) in an aqueous medium. Starch-citrate nanoparticles with mean diameter of 105 nm are subsequently obtained by controlled precipitation through drop-wise addition of dissolved starch-citrate solution into excess absolute ethanol. These nanoparticles are observed to exhibit pH-responsive release profiles within the physiological pH range of 1.2–8.6. The release profile of a model drug (paracetamol) is observed to obey the zero-order kinetics, with the release mechanism based on the diffusion and swelling model. The cytotoxicity study in HaCaT cell lines (human skin cells) shows that starch-citrate nanoparticles are non-toxic and hence are suitable for biomedical applications as pH-responsive drug carriers.
format Article
author Chin, Suk Fun
Ain Nadirah, Romainor
Pang, Suh Cem
Lee, Book Kiat
Hwang, Siaw San
author_facet Chin, Suk Fun
Ain Nadirah, Romainor
Pang, Suh Cem
Lee, Book Kiat
Hwang, Siaw San
author_sort Chin, Suk Fun
title pH-Responsive Starch-Citrate Nanoparticles for Controlled Release of Paracetamol
title_short pH-Responsive Starch-Citrate Nanoparticles for Controlled Release of Paracetamol
title_full pH-Responsive Starch-Citrate Nanoparticles for Controlled Release of Paracetamol
title_fullStr pH-Responsive Starch-Citrate Nanoparticles for Controlled Release of Paracetamol
title_full_unstemmed pH-Responsive Starch-Citrate Nanoparticles for Controlled Release of Paracetamol
title_sort ph-responsive starch-citrate nanoparticles for controlled release of paracetamol
publisher John Wiley & Sons, Inc
publishDate 2019
url http://ir.unimas.my/id/eprint/46265/1/Chin%20et%20al.%2C%202019.pdf
http://ir.unimas.my/id/eprint/46265/
https://onlinelibrary.wiley.com/doi/abs/10.1002/star.201800336
https://doi.org/10.1002/star.201800336
_version_ 1814942142894702592
score 13.223943

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