pH-Responsive Starch-Citrate Nanoparticles for Controlled Release of Paracetamol
Starch-citrate samples with degrees of substitution (DS) ranging from 0.11 to 0.90 are synthesized by a green esterification reaction between citric acid and native sago starch (Metroxylon sagu) in an aqueous medium. Starch-citrate nanoparticles with mean diameter of 105 nm are subsequently obtained...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
John Wiley & Sons, Inc
2019
|
| Subjects: | |
| Online Access: | http://ir.unimas.my/id/eprint/46265/1/Chin%20et%20al.%2C%202019.pdf http://ir.unimas.my/id/eprint/46265/ https://onlinelibrary.wiley.com/doi/abs/10.1002/star.201800336 https://doi.org/10.1002/star.201800336 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Starch-citrate samples with degrees of substitution (DS) ranging from 0.11 to 0.90 are synthesized by a green esterification reaction between citric acid and native sago starch (Metroxylon sagu) in an aqueous medium. Starch-citrate nanoparticles with mean diameter of 105 nm are subsequently obtained by controlled precipitation through drop-wise addition of dissolved starch-citrate solution into excess absolute ethanol. These nanoparticles are observed to exhibit pH-responsive release profiles within the physiological pH range of 1.2–8.6. The release profile of a model drug (paracetamol) is observed to obey the zero-order kinetics, with the release mechanism based on the diffusion and swelling model. The cytotoxicity study in HaCaT cell lines (human skin cells) shows that starch-citrate nanoparticles are non-toxic and hence are suitable for biomedical applications as pH-responsive drug carriers. |
|---|