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The impact of the level of the intestinal short chain Fatty acids in inflammatory bowel disease patients versus healthy subjects.

The aim of this study was to determine the changes of short chain fatty acids (SCFAs) in faeces of inflammatory bowel disease (IBD) patients compared to healthy subjects. SCFAs such as pyruvic, lactic, formic, acetic, propionic, isobutyric and butyric acids were analyzed by using high performance li...

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Main Authors: Faujan, Nur Huda, Abdulamir, Ahmed Sahib, Abu Bakar, Fatimah, O., Muhammad Anas, Mustafa, Shuhaimi, Abd. Manap, Mohd. Yazid, Loong, Yik Yee
Format: Article
Language:English
English
Published: Bentham Science Publishers 2010
Online Access:http://psasir.upm.edu.my/id/eprint/17195/1/The%20impact%20of%20the%20level%20of%20the%20intestinal%20short%20chain%20Fatty%20acids%20in%20inflammatory%20bowel%20disease%20patients%20versus%20healthy%20subjects.pdf
http://psasir.upm.edu.my/id/eprint/17195/
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spelling my.upm.eprints.171952015-10-05T06:33:23Z http://psasir.upm.edu.my/id/eprint/17195/ The impact of the level of the intestinal short chain Fatty acids in inflammatory bowel disease patients versus healthy subjects. Faujan, Nur Huda Abdulamir, Ahmed Sahib Abu Bakar, Fatimah O., Muhammad Anas Mustafa, Shuhaimi Abd. Manap, Mohd. Yazid Loong, Yik Yee The aim of this study was to determine the changes of short chain fatty acids (SCFAs) in faeces of inflammatory bowel disease (IBD) patients compared to healthy subjects. SCFAs such as pyruvic, lactic, formic, acetic, propionic, isobutyric and butyric acids were analyzed by using high performance liquid chromatography (HPLC). This study showed that the level of acetic, 162.0 µmol/g wet faeces, butyric, 86.9 µmol/g wet faeces, and propionic acids, 65.6 µmol/g wet faeces, decreased remarkably in IBD faecal samples when compared with that of healthy individuals, 209.7, 176.0, and 93.3 µmol/g wet faeces respectively. On the contrary, lactic and pyruvic acids showed higher levels in faecal samples of IBD than in healthy subjects. In the context of butyric acid level, this study also found that the molar ratio of butyric acid was higher than propionic acid in both faecal samples. This might be due to the high intake of starch from rice among Malaysian population. It was concluded that the level of SCFAs differ remarkably between faecal samples in healthy subjects and that in IBD patients providing evidence that SCFAs more likely play an important role in the pathogenesis of IBD. Bentham Science Publishers 2010 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/17195/1/The%20impact%20of%20the%20level%20of%20the%20intestinal%20short%20chain%20Fatty%20acids%20in%20inflammatory%20bowel%20disease%20patients%20versus%20healthy%20subjects.pdf Faujan, Nur Huda and Abdulamir, Ahmed Sahib and Abu Bakar, Fatimah and O., Muhammad Anas and Mustafa, Shuhaimi and Abd. Manap, Mohd. Yazid and Loong, Yik Yee (2010) The impact of the level of the intestinal short chain Fatty acids in inflammatory bowel disease patients versus healthy subjects. The Open Biochemistry Journal, 4 (1). pp. 53-58. ISSN 1321-3378 10.2174/1874091X01004010053 English
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
English
description The aim of this study was to determine the changes of short chain fatty acids (SCFAs) in faeces of inflammatory bowel disease (IBD) patients compared to healthy subjects. SCFAs such as pyruvic, lactic, formic, acetic, propionic, isobutyric and butyric acids were analyzed by using high performance liquid chromatography (HPLC). This study showed that the level of acetic, 162.0 µmol/g wet faeces, butyric, 86.9 µmol/g wet faeces, and propionic acids, 65.6 µmol/g wet faeces, decreased remarkably in IBD faecal samples when compared with that of healthy individuals, 209.7, 176.0, and 93.3 µmol/g wet faeces respectively. On the contrary, lactic and pyruvic acids showed higher levels in faecal samples of IBD than in healthy subjects. In the context of butyric acid level, this study also found that the molar ratio of butyric acid was higher than propionic acid in both faecal samples. This might be due to the high intake of starch from rice among Malaysian population. It was concluded that the level of SCFAs differ remarkably between faecal samples in healthy subjects and that in IBD patients providing evidence that SCFAs more likely play an important role in the pathogenesis of IBD.
format Article
author Faujan, Nur Huda
Abdulamir, Ahmed Sahib
Abu Bakar, Fatimah
O., Muhammad Anas
Mustafa, Shuhaimi
Abd. Manap, Mohd. Yazid
Loong, Yik Yee
spellingShingle Faujan, Nur Huda
Abdulamir, Ahmed Sahib
Abu Bakar, Fatimah
O., Muhammad Anas
Mustafa, Shuhaimi
Abd. Manap, Mohd. Yazid
Loong, Yik Yee
The impact of the level of the intestinal short chain Fatty acids in inflammatory bowel disease patients versus healthy subjects.
author_facet Faujan, Nur Huda
Abdulamir, Ahmed Sahib
Abu Bakar, Fatimah
O., Muhammad Anas
Mustafa, Shuhaimi
Abd. Manap, Mohd. Yazid
Loong, Yik Yee
author_sort Faujan, Nur Huda
title The impact of the level of the intestinal short chain Fatty acids in inflammatory bowel disease patients versus healthy subjects.
title_short The impact of the level of the intestinal short chain Fatty acids in inflammatory bowel disease patients versus healthy subjects.
title_full The impact of the level of the intestinal short chain Fatty acids in inflammatory bowel disease patients versus healthy subjects.
title_fullStr The impact of the level of the intestinal short chain Fatty acids in inflammatory bowel disease patients versus healthy subjects.
title_full_unstemmed The impact of the level of the intestinal short chain Fatty acids in inflammatory bowel disease patients versus healthy subjects.
title_sort impact of the level of the intestinal short chain fatty acids in inflammatory bowel disease patients versus healthy subjects.
publisher Bentham Science Publishers
publishDate 2010
url http://psasir.upm.edu.my/id/eprint/17195/1/The%20impact%20of%20the%20level%20of%20the%20intestinal%20short%20chain%20Fatty%20acids%20in%20inflammatory%20bowel%20disease%20patients%20versus%20healthy%20subjects.pdf
http://psasir.upm.edu.my/id/eprint/17195/
_version_ 1643826442697441280
score 13.211869

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