Cover Image

Development of small molecule inhibitors targeting TGF-beta ligand and receptor: Structures, mechanism, preclinical studies and clinical usage

Transforming growth factor-beta (TGF-beta) is a member of a superfamily of pleiotropic proteins that regulate multiple cellular processes such as growth, development and differentiation. Following binding to type I and II TGF-beta serine/threonine kinase receptors, TGF-beta activates downstream sign...

Full description

Saved in:

Bibliographic Details
Main Authors:	Wang, Hao, Chen, Meiling, Sang, Xiaohong, You, Xuefu, Wang, Yucheng, Paterson, Ian Charles, Hong, Wei, Yang, Xinyi
Format:	Article
Published:	Elsevier 2020
Subjects:	R Medicine
Online Access:	http://eprints.um.edu.my/36800/
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Development of small molecule inhibitors targeting TGF-β ligand and receptor: Structures, mechanism, preclinical studies and clinical usage
by: Wang, Hao, et al.
Published: (2020)

The development of a novel transforming growth factor-β (TGF-β) inhibitor that disrupts ligand-receptor interactions
by: Wu, Han, et al.
Published: (2020)

Autophagy is deregulated in cancer-associated fibroblasts from oral cancer and is stimulated during the induction of fibroblast senescence by TGF-beta 1
by: Tan, May Leng, et al.
Published: (2021)

TGFβ-1 and ALK5 inhibitor treatment affects expressions of TGF β signalling pathway associated molecules in SHED cultured in keratinocyte growth medium
by: Mokhtar@Makhtar, Khairani Idah, et al.
Published: (2015)

Supplementation of TGF-Beta3 in low serum media promotes chondrogenesis of BMSCs
by: Alfaqeh, Hamoud Hussein Mohammed, et al.
Published: (2017)

Supplementation of TGF-Beta3 in low serum media promotes chondrogenesis of BMSCs
by: Alfaqeh, Hamoud Hussein, et al.
Published: (2017)

Homology Modeling and Molecular Docking Studies on Type II Diabetes Complications Reduced PPARγ Receptor with Various Ligand Molecules
by: Prabhu, S., et al.
Published: (2017)

Effect of TGF-beta 1 antisense oligodeoxynucleotide on renal function in chronic renal failure rats
by: Hiong, L.C., et al.
Published: (2008)

Hydrophilic bile acid, ursodeoxycholic acid attenuates the effect of tgf-beta 1 on human tenon's fibroblast
by: Roslan, Zulaika, et al.
Published: (2021)

TGF-ß1 signalling, connecting aberrant inflammation and colorectal tumorigenesis
by: Paterson, I.C., et al.
Published: (2012)

Differential expression of Notch receptors and their ligands in desmoplastic ameloblastoma
by: Siar, C.H., et al.
Published: (2010)

Effect of Transforming Growth Factor-Beta signalling on SHED cultured in keratinocytes differentiation medium treated with TGF-B1 and ALK-5 inhibitor
by: Azmi, Nur Izyan, et al.
Published: (2016)

Molecular modeling of muscarinic acetylcholine receptors: Structural basis of ligand-receptor interactions / Chin Sek Peng
by: Chin, Sek Peng
Published: (2015)

Inflammatory role of transforming growth factor beta-1 (TGF-β1) in multistep progression of gastric oncogenesis: an immunohistochemical study
by: Ismail, Ahmad Zharif, et al.
Published: (2015)

Study of Beta 2-Adrenergic Receptor Polymorphisms among Hypertensives
by: Atia, Ahmad Elbadry, et al.
Published: (2010)

Computational ligand–receptor docking simulation of piperine with apoptosis-associated factors
by: Adrianne Dien Yu, Vong, et al.
Published: (2022)

P2Y purinergic receptor signaling in oral squamous cell carcinoma cell lines and its role in proliferation and cisplatin-mediated apoptosis
by: Lok, Mun Law, et al.
Published: (2022)

P2Y purinergic receptor signaling in oral squamous cell carcinoma cell lines and its role in proliferation and cisplatin-mediated apoptosis
by: Law, Lok Mun, et al.
Published: (2022)

The discovery of 1, 3-diamino-7H-pyrrol3, 2-f]quinazoline compounds as potent antimicrobial antifolates
by: Li, Yue, et al.
Published: (2022)

Synthesis and evaluation of nuciferine and roemerine enantiomers as 5-HT2 and α1 receptor antagonists
by: Heng, Hui Li, et al.
Published: (2018)

Small molecules as LIM kinase inhibitors
by: Bukhari, Syed N. A., et al.
Published: (2022)

Selectively promiscuous opioid ligands: discovery of high affinity/low efficacy opioid ligands with substantial nociceptin opioid peptide receptor affinity
by: Kumar, Vinod, et al.
Published: (2014)

Preliminary study on the expression of Estrogen Receptor Beta (ERβ) in colorectal carcinoma
by: Azmahani, Abdullah, et al.
Published: (2020)

Role of co-expression of estrogen receptor beta and Ki67 in prostate adenocarcinoma
by: Nornazirah Azizan, et al.
Published: (2018)

TGF-β-induced fibrosis: a review on the underlying mechanism and potential therapeutic strategies
by: Ong, Chun Hao, et al.
Published: (2021)

Expressin of Interleukin 4, Interleukin 4 Receptor and IL-4 Receptor Related GP200-MR6 Molecule in Pterygium and Normal Bulbar Conjunctiva Tissue
by: Go, Eng Soon
Published: (2001)

Experimental and density functional theory investigations on the structural and electronic properties of acyclovir and theophylline hydrate molecules
by: Wang, Suh Miin
Published: (2021)

Signal transduction from ligand-receptor binding associated with the formation of invadopodia in an invasive cancer cell
by: Yaacob, Noorehan, et al.
Published: (2022)

A comparison study on aqueous humor transforming growth factor-beta (TGF-β) and vascular endothelial growth factor (VEGF) level in primary glaucoma patients and controls
by: Samsudin, Norhayaty
Published: (2017)

Preclinical evidence of Malay traditional herbal supplement for diabetes
by: Abdul Majid, Fadzilah Adibah, et al.
Published: (2016)

Preclinical and clinical effects of mistletoe against breast cancer
by: Marvibaigi, Mohsen, et al.
Published: (2014)

Preclinical evidence of Malay traditional herbal supplement for diabetes
by: Majid, F. A. A., et al.
Published: (2016)

Clinical students’ reflections on the preclinical anatomy learning experience
by: Syarifah A., Syed Abd Halim, et al.
Published: (2023)

Influence of nitrogen-containing chelating ligands on the structures of zinc(II) 4,4′-ethylenedibenzoates
by: Wang, Xiu Yan, et al.
Published: (2008)

Assessment of preclinical pharmacokinetics and acute toxicity of pioglitazone and telmisartan combination
by: Sengupta, Pinaki Ranjan, et al.
Published: (2017)

Assessment of knowledge on forensic anatomy among preclinical medical students
by: Manah Chandra Changmai,, et al.
Published: (2016)

“Speedy Biochemistry” as a new teaching method in preclinical curriculum
by: Noor Akmal Shareela Ismail,
Published: (2020)

Physical health of preclinical medical students during Covid-19
by: Nor Azlan, Nur Khairunnisa, et al.
Published: (2021)

Physical health of preclinical medical students during covid-19
by: Nor Azlan, Nur Khairunnisa, et al.
Published: (2021)

Clinical and preclinical studies of fermented foods and their effects on Alzheimer’s disease
by: Kumar, Muganti Rajah, et al.
Published: (2022)