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DNA repair at the gene level in trichothiodystrophy cells

Cells from trichothiodystrophy (TTD) group 3 patients are non-hypersensitive to uv irradiation. These cells perform normal genome repair of pyrimidine dimers but fail to excise 6-4 photoproducts and concomitantly, are unable to restore RNA synthesis levels following uv irradiation. This pointed to a...

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Main Authors: Nathan , Sheila, Mayne, Lynne
Format: Article
Published: Universiti Kebangsaan Malaysia 2000
Online Access:http://journalarticle.ukm.my/3779/
http://www.ukm.my/jsm/english_journals/vol29_2000/vol29_00page19-31.html
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spelling my-ukm.journal.37792012-03-20T01:56:29Z http://journalarticle.ukm.my/3779/ DNA repair at the gene level in trichothiodystrophy cells Nathan , Sheila Mayne, Lynne Cells from trichothiodystrophy (TTD) group 3 patients are non-hypersensitive to uv irradiation. These cells perform normal genome repair of pyrimidine dimers but fail to excise 6-4 photoproducts and concomitantly, are unable to restore RNA synthesis levels following uv irradiation. This pointed to a defect in gene-specific repair and this study was undertaken to examine repair of dimers at the gene-level. The results indicated a defect in gene-specific repair of dimers at early times post-irradiation due to the inability of the cells to repair dimers from the transcribed strand of the active gene. These findings indicate that TTD group 3 cells are unable to remove DNA lesions preferen­tially and this might contribute to other inherent symptoms of these patients. Universiti Kebangsaan Malaysia 2000 Article PeerReviewed Nathan , Sheila and Mayne, Lynne (2000) DNA repair at the gene level in trichothiodystrophy cells. Sains Malaysiana, 29 . pp. 19-31. ISSN 0126-6039 http://www.ukm.my/jsm/english_journals/vol29_2000/vol29_00page19-31.html
institution Universiti Kebangsaan Malaysia
building Perpustakaan Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
description Cells from trichothiodystrophy (TTD) group 3 patients are non-hypersensitive to uv irradiation. These cells perform normal genome repair of pyrimidine dimers but fail to excise 6-4 photoproducts and concomitantly, are unable to restore RNA synthesis levels following uv irradiation. This pointed to a defect in gene-specific repair and this study was undertaken to examine repair of dimers at the gene-level. The results indicated a defect in gene-specific repair of dimers at early times post-irradiation due to the inability of the cells to repair dimers from the transcribed strand of the active gene. These findings indicate that TTD group 3 cells are unable to remove DNA lesions preferen­tially and this might contribute to other inherent symptoms of these patients.
format Article
author Nathan , Sheila
Mayne, Lynne
spellingShingle Nathan , Sheila
Mayne, Lynne
DNA repair at the gene level in trichothiodystrophy cells
author_facet Nathan , Sheila
Mayne, Lynne
author_sort Nathan , Sheila
title DNA repair at the gene level in trichothiodystrophy cells
title_short DNA repair at the gene level in trichothiodystrophy cells
title_full DNA repair at the gene level in trichothiodystrophy cells
title_fullStr DNA repair at the gene level in trichothiodystrophy cells
title_full_unstemmed DNA repair at the gene level in trichothiodystrophy cells
title_sort dna repair at the gene level in trichothiodystrophy cells
publisher Universiti Kebangsaan Malaysia
publishDate 2000
url http://journalarticle.ukm.my/3779/
http://www.ukm.my/jsm/english_journals/vol29_2000/vol29_00page19-31.html
_version_ 1643735843703095296
score 13.211869

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