Biophysical properties of DNA in hydrated ionic liquids
The biophysical properties and behavior of natural calf thymus DNA in hydrated 1-ethyl-3-butylimidazolium bromide ionic liquid (C2bimBr) have been studied using spectroscopy technique. The effect of ionic liquid concentration and temperature towards the duplex B-DNA conformation were determined. The...
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American Institute of Physics Inc.
2016
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my.utp.eprints.305932022-03-25T07:12:10Z Biophysical properties of DNA in hydrated ionic liquids Jumbri, K. Ahmad, H. Abdulmalek, E. Rahman, M.B.A. The biophysical properties and behavior of natural calf thymus DNA in hydrated 1-ethyl-3-butylimidazolium bromide ionic liquid (C2bimBr) have been studied using spectroscopy technique. The effect of ionic liquid concentration and temperature towards the duplex B-DNA conformation were determined. The presence of ionic liquid causes higher duplex DNA stability with the DNA melting temperature of �56°C without any addition of buffer solutions. The electrostatic attraction between ionic liquid's cation and DNA phosphates groups was found play a main role in stabilizing native DNA structure. Understanding of the biophysical properties of DNA in this ionic media could be used as a platform for future development of specific solvent for nucleic acid nanotechnology. © 2016 Author(s). American Institute of Physics Inc. 2016 Conference or Workshop Item NonPeerReviewed https://www.scopus.com/inward/record.uri?eid=2-s2.0-85006056274&doi=10.1063%2f1.4968137&partnerID=40&md5=79f5dc44cef8ceb3dd6c71b18cd87b6b Jumbri, K. and Ahmad, H. and Abdulmalek, E. and Rahman, M.B.A. (2016) Biophysical properties of DNA in hydrated ionic liquids. In: UNSPECIFIED. http://eprints.utp.edu.my/30593/ |
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The biophysical properties and behavior of natural calf thymus DNA in hydrated 1-ethyl-3-butylimidazolium bromide ionic liquid (C2bimBr) have been studied using spectroscopy technique. The effect of ionic liquid concentration and temperature towards the duplex B-DNA conformation were determined. The presence of ionic liquid causes higher duplex DNA stability with the DNA melting temperature of �56°C without any addition of buffer solutions. The electrostatic attraction between ionic liquid's cation and DNA phosphates groups was found play a main role in stabilizing native DNA structure. Understanding of the biophysical properties of DNA in this ionic media could be used as a platform for future development of specific solvent for nucleic acid nanotechnology. © 2016 Author(s). |
| format |
Conference or Workshop Item |
| author |
Jumbri, K. Ahmad, H. Abdulmalek, E. Rahman, M.B.A. |
| spellingShingle |
Jumbri, K. Ahmad, H. Abdulmalek, E. Rahman, M.B.A. Biophysical properties of DNA in hydrated ionic liquids |
| author_facet |
Jumbri, K. Ahmad, H. Abdulmalek, E. Rahman, M.B.A. |
| author_sort |
Jumbri, K. |
| title |
Biophysical properties of DNA in hydrated ionic liquids |
| title_short |
Biophysical properties of DNA in hydrated ionic liquids |
| title_full |
Biophysical properties of DNA in hydrated ionic liquids |
| title_fullStr |
Biophysical properties of DNA in hydrated ionic liquids |
| title_full_unstemmed |
Biophysical properties of DNA in hydrated ionic liquids |
| title_sort |
biophysical properties of dna in hydrated ionic liquids |
| publisher |
American Institute of Physics Inc. |
| publishDate |
2016 |
| url |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85006056274&doi=10.1063%2f1.4968137&partnerID=40&md5=79f5dc44cef8ceb3dd6c71b18cd87b6b http://eprints.utp.edu.my/30593/ |
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13.250461 |