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D-optimal design-assisted Elaeis guineensis leaves extract in olive oil-sunflower seed nanoemulsions: development, characterization, and physical stability

A three-factor D-optimal mixture design was used to prepare the Elaeis guineensis leaves extract (EgLE) in olive oil-sunflower seed nanoemulsions. The assessed independent variables were the components of an oil-based nanoemulsion that included oil (8–12%, w/w), Span 80:Brij L23 (28–30%, w/w) and aq...

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Main Authors: Bharrathi Romes, Nissha, Abdul Wahab, Roswanira, Abdul Hamid, Mariani, Hashim, Siti Ernieyanti
Format: Article
Published: Bellwether Publishing, Ltd. 2020
Subjects:
QD Chemistry
Online Access:http://eprints.utm.my/id/eprint/91682/
http://dx.doi.org/10.1080/01932691.2020.1839484
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spelling my.utm.916822021-07-26T23:37:16Z http://eprints.utm.my/id/eprint/91682/ D-optimal design-assisted Elaeis guineensis leaves extract in olive oil-sunflower seed nanoemulsions: development, characterization, and physical stability Bharrathi Romes, Nissha Abdul Wahab, Roswanira Abdul Hamid, Mariani Hashim, Siti Ernieyanti QD Chemistry A three-factor D-optimal mixture design was used to prepare the Elaeis guineensis leaves extract (EgLE) in olive oil-sunflower seed nanoemulsions. The assessed independent variables were the components of an oil-based nanoemulsion that included oil (8–12%, w/w), Span 80:Brij L23 (28–30%, w/w) and aqueous (56–60% w/w) with mean droplet size (MDS) and polydispersity index (PDI) as the responses. Analysis of variance revealed that both responses fitted a quadratic polynomial model and a residual standard error of <5% indicated good agreement between the experimental and predicted values. Optimal formulation with the lowest MDS and PDI was established to be 10% (w/w) oil, 29% (w/w) Span 80:Brij L23 and aqueous at 58% (w/w). Atomic force micrographs showed the MDS of an optimized EgLE w/o nanoemulsion being <200 nm and was kinetically stable (zeta potential: −30.0 ± 0.7 mV). The system showed satisfactory conductivity (0.70 ± 0.02 µS cm−1) and pH (5.6 ± 0.3), alongside resistance to phase separation under centrifugation and freeze-thaw cycles. The nanoemulsion also exhibited shear thinning and pseudoplastic properties, implying good stability against destabilization by coalescence. It can be construed that the developed EgLE nanoemulsion showed potential as a natural-based personal care product. This is the first report on the preparation of EgLE as bioactive ingredients in a w/o nanoemulsion for topical application. Bellwether Publishing, Ltd. 2020 Article PeerReviewed Bharrathi Romes, Nissha and Abdul Wahab, Roswanira and Abdul Hamid, Mariani and Hashim, Siti Ernieyanti (2020) D-optimal design-assisted Elaeis guineensis leaves extract in olive oil-sunflower seed nanoemulsions: development, characterization, and physical stability. Journal of Dispersion Science and Technology . ISSN 0193-2691 http://dx.doi.org/10.1080/01932691.2020.1839484
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
topic QD Chemistry
spellingShingle QD Chemistry
Bharrathi Romes, Nissha
Abdul Wahab, Roswanira
Abdul Hamid, Mariani
Hashim, Siti Ernieyanti
D-optimal design-assisted Elaeis guineensis leaves extract in olive oil-sunflower seed nanoemulsions: development, characterization, and physical stability
description A three-factor D-optimal mixture design was used to prepare the Elaeis guineensis leaves extract (EgLE) in olive oil-sunflower seed nanoemulsions. The assessed independent variables were the components of an oil-based nanoemulsion that included oil (8–12%, w/w), Span 80:Brij L23 (28–30%, w/w) and aqueous (56–60% w/w) with mean droplet size (MDS) and polydispersity index (PDI) as the responses. Analysis of variance revealed that both responses fitted a quadratic polynomial model and a residual standard error of <5% indicated good agreement between the experimental and predicted values. Optimal formulation with the lowest MDS and PDI was established to be 10% (w/w) oil, 29% (w/w) Span 80:Brij L23 and aqueous at 58% (w/w). Atomic force micrographs showed the MDS of an optimized EgLE w/o nanoemulsion being <200 nm and was kinetically stable (zeta potential: −30.0 ± 0.7 mV). The system showed satisfactory conductivity (0.70 ± 0.02 µS cm−1) and pH (5.6 ± 0.3), alongside resistance to phase separation under centrifugation and freeze-thaw cycles. The nanoemulsion also exhibited shear thinning and pseudoplastic properties, implying good stability against destabilization by coalescence. It can be construed that the developed EgLE nanoemulsion showed potential as a natural-based personal care product. This is the first report on the preparation of EgLE as bioactive ingredients in a w/o nanoemulsion for topical application.
format Article
author Bharrathi Romes, Nissha
Abdul Wahab, Roswanira
Abdul Hamid, Mariani
Hashim, Siti Ernieyanti
author_facet Bharrathi Romes, Nissha
Abdul Wahab, Roswanira
Abdul Hamid, Mariani
Hashim, Siti Ernieyanti
author_sort Bharrathi Romes, Nissha
title D-optimal design-assisted Elaeis guineensis leaves extract in olive oil-sunflower seed nanoemulsions: development, characterization, and physical stability
title_short D-optimal design-assisted Elaeis guineensis leaves extract in olive oil-sunflower seed nanoemulsions: development, characterization, and physical stability
title_full D-optimal design-assisted Elaeis guineensis leaves extract in olive oil-sunflower seed nanoemulsions: development, characterization, and physical stability
title_fullStr D-optimal design-assisted Elaeis guineensis leaves extract in olive oil-sunflower seed nanoemulsions: development, characterization, and physical stability
title_full_unstemmed D-optimal design-assisted Elaeis guineensis leaves extract in olive oil-sunflower seed nanoemulsions: development, characterization, and physical stability
title_sort d-optimal design-assisted elaeis guineensis leaves extract in olive oil-sunflower seed nanoemulsions: development, characterization, and physical stability
publisher Bellwether Publishing, Ltd.
publishDate 2020
url http://eprints.utm.my/id/eprint/91682/
http://dx.doi.org/10.1080/01932691.2020.1839484
_version_ 1706956980077199360
score 13.211869

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