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Synthesis, characterization, in silico and antifungal studies of thiazolidine analogues

A series of sixteen novel heterocyclic thiazolidine derivatives (3a-p) was synthesized upon reaction of L-cysteine with different substituted benzaldehyde. The synthesized compounds were extensively characterized by IR, 1H and 13C NMR spectral analysis. All compounds were evaluated for their anti-fu...

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Main Authors: Abid, F. M. A., Jamalis, J., Chander, S., Wahab, R. A., Bhagwat, D. P., Sankaranarayanan, M.
Format: Article
Published: Elsevier B. V. 2019
Subjects:
Q Science (General)
Online Access:http://eprints.utm.my/id/eprint/89748/
https://dx.doi.org/10.1016/j.cdc.2019.100219
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spelling my.utm.897482021-02-22T01:45:04Z http://eprints.utm.my/id/eprint/89748/ Synthesis, characterization, in silico and antifungal studies of thiazolidine analogues Abid, F. M. A. Jamalis, J. Chander, S. Wahab, R. A. Bhagwat, D. P. Sankaranarayanan, M. Q Science (General) A series of sixteen novel heterocyclic thiazolidine derivatives (3a-p) was synthesized upon reaction of L-cysteine with different substituted benzaldehyde. The synthesized compounds were extensively characterized by IR, 1H and 13C NMR spectral analysis. All compounds were evaluated for their anti-fungal activity against Candida albicans and Aspergillus niger using fluconazole as reference drug. The assay revealed that, compound 3k showed significant activity (14 mm ZOI, 64 µg/mL IC50 and 15 mm ZOI, >32 µg/mL IC50) against C. albicans and A. niger, respectively. Elsevier B. V. 2019-06 Article PeerReviewed Abid, F. M. A. and Jamalis, J. and Chander, S. and Wahab, R. A. and Bhagwat, D. P. and Sankaranarayanan, M. (2019) Synthesis, characterization, in silico and antifungal studies of thiazolidine analogues. Chemical Data Collections, 21 . ISSN 2405-8300 https://dx.doi.org/10.1016/j.cdc.2019.100219 DOI: 10.1016/j.cdc.2019.100219
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
topic Q Science (General)
spellingShingle Q Science (General)
Abid, F. M. A.
Jamalis, J.
Chander, S.
Wahab, R. A.
Bhagwat, D. P.
Sankaranarayanan, M.
Synthesis, characterization, in silico and antifungal studies of thiazolidine analogues
description A series of sixteen novel heterocyclic thiazolidine derivatives (3a-p) was synthesized upon reaction of L-cysteine with different substituted benzaldehyde. The synthesized compounds were extensively characterized by IR, 1H and 13C NMR spectral analysis. All compounds were evaluated for their anti-fungal activity against Candida albicans and Aspergillus niger using fluconazole as reference drug. The assay revealed that, compound 3k showed significant activity (14 mm ZOI, 64 µg/mL IC50 and 15 mm ZOI, >32 µg/mL IC50) against C. albicans and A. niger, respectively.
format Article
author Abid, F. M. A.
Jamalis, J.
Chander, S.
Wahab, R. A.
Bhagwat, D. P.
Sankaranarayanan, M.
author_facet Abid, F. M. A.
Jamalis, J.
Chander, S.
Wahab, R. A.
Bhagwat, D. P.
Sankaranarayanan, M.
author_sort Abid, F. M. A.
title Synthesis, characterization, in silico and antifungal studies of thiazolidine analogues
title_short Synthesis, characterization, in silico and antifungal studies of thiazolidine analogues
title_full Synthesis, characterization, in silico and antifungal studies of thiazolidine analogues
title_fullStr Synthesis, characterization, in silico and antifungal studies of thiazolidine analogues
title_full_unstemmed Synthesis, characterization, in silico and antifungal studies of thiazolidine analogues
title_sort synthesis, characterization, in silico and antifungal studies of thiazolidine analogues
publisher Elsevier B. V.
publishDate 2019
url http://eprints.utm.my/id/eprint/89748/
https://dx.doi.org/10.1016/j.cdc.2019.100219
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score 13.211869

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