Synthesis, characterization, in silico and antifungal studies of thiazolidine analogues
A series of sixteen novel heterocyclic thiazolidine derivatives (3a-p) was synthesized upon reaction of L-cysteine with different substituted benzaldehyde. The synthesized compounds were extensively characterized by IR, 1H and 13C NMR spectral analysis. All compounds were evaluated for their anti-fu...
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| Main Authors: | , , , , , |
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| Format: | Article |
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Elsevier B. V.
2019
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| Subjects: | |
| Online Access: | http://eprints.utm.my/id/eprint/89748/ https://dx.doi.org/10.1016/j.cdc.2019.100219 |
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| Summary: | A series of sixteen novel heterocyclic thiazolidine derivatives (3a-p) was synthesized upon reaction of L-cysteine with different substituted benzaldehyde. The synthesized compounds were extensively characterized by IR, 1H and 13C NMR spectral analysis. All compounds were evaluated for their anti-fungal activity against Candida albicans and Aspergillus niger using fluconazole as reference drug. The assay revealed that, compound 3k showed significant activity (14 mm ZOI, 64 µg/mL IC50 and 15 mm ZOI, >32 µg/mL IC50) against C. albicans and A. niger, respectively. |
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