Madangones A and B: two new neolignans from the stem bark of Beilschmiedia madang and their bioactivities
Two new neolignans, madangones A (1) and B (2), together with (+)-kunstlerone (3), vanillin, vanillic acid, betulin, β-sitosterol and β-sitostenone, were isolated from the stem bark of Beilschmiedia madang (Lauraceae). The structures of the compounds were determined by spectroscopic means. The compo...
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2016
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my.utm.738262017-11-18T07:54:21Z http://eprints.utm.my/id/eprint/73826/ Madangones A and B: two new neolignans from the stem bark of Beilschmiedia madang and their bioactivities Salleh, W.M.N.H.W. Ahmad, F. Yen, K.H. Zulkifli, R.M. Sarker, S.D. QD Chemistry Two new neolignans, madangones A (1) and B (2), together with (+)-kunstlerone (3), vanillin, vanillic acid, betulin, β-sitosterol and β-sitostenone, were isolated from the stem bark of Beilschmiedia madang (Lauraceae). The structures of the compounds were determined by spectroscopic means. The compounds were tested for antioxidant, acetylcholinesterase inhibitory and anti-inflammatory activities. Compound (3) displayed the strongest DPPH radical-scavenging activity with an IC50 value of 68.7 μM. Compound (2) exhibited the highest level of activity on the COX-2 model and acetylcholinesterase inhibition assay, with IC50 values of 27.4 and 70.3 μM, respectively. Elsevier Ltd 2016 Article PeerReviewed Salleh, W.M.N.H.W. and Ahmad, F. and Yen, K.H. and Zulkifli, R.M. and Sarker, S.D. (2016) Madangones A and B: two new neolignans from the stem bark of Beilschmiedia madang and their bioactivities. Phytochemistry Letters, 15 . pp. 168-173. ISSN 1874-3900 https://www.scopus.com/inward/record.uri?eid=2-s2.0-84954270929&doi=10.1016%2fj.phytol.2016.01.004&partnerID=40&md5=399a7a02c3ad70d2c3179f6737994078 |
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QD Chemistry Salleh, W.M.N.H.W. Ahmad, F. Yen, K.H. Zulkifli, R.M. Sarker, S.D. Madangones A and B: two new neolignans from the stem bark of Beilschmiedia madang and their bioactivities |
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Two new neolignans, madangones A (1) and B (2), together with (+)-kunstlerone (3), vanillin, vanillic acid, betulin, β-sitosterol and β-sitostenone, were isolated from the stem bark of Beilschmiedia madang (Lauraceae). The structures of the compounds were determined by spectroscopic means. The compounds were tested for antioxidant, acetylcholinesterase inhibitory and anti-inflammatory activities. Compound (3) displayed the strongest DPPH radical-scavenging activity with an IC50 value of 68.7 μM. Compound (2) exhibited the highest level of activity on the COX-2 model and acetylcholinesterase inhibition assay, with IC50 values of 27.4 and 70.3 μM, respectively. |
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Article |
| author |
Salleh, W.M.N.H.W. Ahmad, F. Yen, K.H. Zulkifli, R.M. Sarker, S.D. |
| author_facet |
Salleh, W.M.N.H.W. Ahmad, F. Yen, K.H. Zulkifli, R.M. Sarker, S.D. |
| author_sort |
Salleh, W.M.N.H.W. |
| title |
Madangones A and B: two new neolignans from the stem bark of Beilschmiedia madang and their bioactivities |
| title_short |
Madangones A and B: two new neolignans from the stem bark of Beilschmiedia madang and their bioactivities |
| title_full |
Madangones A and B: two new neolignans from the stem bark of Beilschmiedia madang and their bioactivities |
| title_fullStr |
Madangones A and B: two new neolignans from the stem bark of Beilschmiedia madang and their bioactivities |
| title_full_unstemmed |
Madangones A and B: two new neolignans from the stem bark of Beilschmiedia madang and their bioactivities |
| title_sort |
madangones a and b: two new neolignans from the stem bark of beilschmiedia madang and their bioactivities |
| publisher |
Elsevier Ltd |
| publishDate |
2016 |
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http://eprints.utm.my/id/eprint/73826/ https://www.scopus.com/inward/record.uri?eid=2-s2.0-84954270929&doi=10.1016%2fj.phytol.2016.01.004&partnerID=40&md5=399a7a02c3ad70d2c3179f6737994078 |
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13.211869 |