Madangones A and B: two new neolignans from the stem bark of Beilschmiedia madang and their bioactivities
Two new neolignans, madangones A (1) and B (2), together with (+)-kunstlerone (3), vanillin, vanillic acid, betulin, β-sitosterol and β-sitostenone, were isolated from the stem bark of Beilschmiedia madang (Lauraceae). The structures of the compounds were determined by spectroscopic means. The compo...
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| Main Authors: | , , , , |
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| Format: | Article |
| Published: |
Elsevier Ltd
2016
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| Subjects: | |
| Online Access: | http://eprints.utm.my/id/eprint/73826/ https://www.scopus.com/inward/record.uri?eid=2-s2.0-84954270929&doi=10.1016%2fj.phytol.2016.01.004&partnerID=40&md5=399a7a02c3ad70d2c3179f6737994078 |
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| Summary: | Two new neolignans, madangones A (1) and B (2), together with (+)-kunstlerone (3), vanillin, vanillic acid, betulin, β-sitosterol and β-sitostenone, were isolated from the stem bark of Beilschmiedia madang (Lauraceae). The structures of the compounds were determined by spectroscopic means. The compounds were tested for antioxidant, acetylcholinesterase inhibitory and anti-inflammatory activities. Compound (3) displayed the strongest DPPH radical-scavenging activity with an IC50 value of 68.7 μM. Compound (2) exhibited the highest level of activity on the COX-2 model and acetylcholinesterase inhibition assay, with IC50 values of 27.4 and 70.3 μM, respectively. |
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