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Finite element analysis of single cell stiffness measurements using PZT- integrated buckling nanoneedles

This paper proposes a new technique for real-time single cell stiffness measurement using lead zirconate titanate (PZT)-integrated buckling nanoneedles. The PZT and the buckling part of the nanoneedle have been modelled and validated using the ABAQUS software. The two parts are integrated together t...

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Main Authors: Alsadat Rad, Maryam, Tijjani, Auwal Shehu, Ahmad, Mohd Ridzuan, Muhammad Auwal, Shehu
Format: Article
Published: MDPI AG 2017
Subjects:
TK Electrical engineering. Electronics Nuclear engineering
Online Access:http://eprints.utm.my/id/eprint/66475/
http://dx.doi.org/10.3390/s17010014
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spelling my.utm.664752017-10-03T13:10:36Z http://eprints.utm.my/id/eprint/66475/ Finite element analysis of single cell stiffness measurements using PZT- integrated buckling nanoneedles Alsadat Rad, Maryam Tijjani, Auwal Shehu Ahmad, Mohd Ridzuan Muhammad Auwal, Shehu TK Electrical engineering. Electronics Nuclear engineering This paper proposes a new technique for real-time single cell stiffness measurement using lead zirconate titanate (PZT)-integrated buckling nanoneedles. The PZT and the buckling part of the nanoneedle have been modelled and validated using the ABAQUS software. The two parts are integrated together to function as a single unit. After calibration, the stiffness, Young’s modulus, Poisson’s ratio and sensitivity of the PZT-integrated buckling nanoneedle have been determined to be 0.7100 N·m−1, 123.4700 GPa, 0.3000 and 0.0693 V·m·N−1, respectively. Three Saccharomyces cerevisiae cells have been modelled and validated based on compression tests. The average global stiffness and Young’s modulus of the cells are determined to be 10.8867 ± 0.0094 N·m−1 and 110.7033 ± 0.0081 MPa, respectively. The nanoneedle and the cell have been assembled to measure the local stiffness of the single Saccharomyces cerevisiae cells The local stiffness, Young’s modulus and PZT output voltage of the three different size Saccharomyces cerevisiae have been determined at different environmental conditions. We investigated that, at low temperature the stiffness value is low to adapt to the change in the environmental condition. As a result, Saccharomyces cerevisiae becomes vulnerable to viral and bacterial attacks. Therefore, the proposed technique will serve as a quick and accurate process to diagnose diseases at early stage in a cell for effective treatment. MDPI AG 2017-01-01 Article PeerReviewed Alsadat Rad, Maryam and Tijjani, Auwal Shehu and Ahmad, Mohd Ridzuan and Muhammad Auwal, Shehu (2017) Finite element analysis of single cell stiffness measurements using PZT- integrated buckling nanoneedles. Sensors, 17 (1). p. 14. ISSN 1424-8220 http://dx.doi.org/10.3390/s17010014 DOI:10.3390/s17010014
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
topic TK Electrical engineering. Electronics Nuclear engineering
spellingShingle TK Electrical engineering. Electronics Nuclear engineering
Alsadat Rad, Maryam
Tijjani, Auwal Shehu
Ahmad, Mohd Ridzuan
Muhammad Auwal, Shehu
Finite element analysis of single cell stiffness measurements using PZT- integrated buckling nanoneedles
description This paper proposes a new technique for real-time single cell stiffness measurement using lead zirconate titanate (PZT)-integrated buckling nanoneedles. The PZT and the buckling part of the nanoneedle have been modelled and validated using the ABAQUS software. The two parts are integrated together to function as a single unit. After calibration, the stiffness, Young’s modulus, Poisson’s ratio and sensitivity of the PZT-integrated buckling nanoneedle have been determined to be 0.7100 N·m−1, 123.4700 GPa, 0.3000 and 0.0693 V·m·N−1, respectively. Three Saccharomyces cerevisiae cells have been modelled and validated based on compression tests. The average global stiffness and Young’s modulus of the cells are determined to be 10.8867 ± 0.0094 N·m−1 and 110.7033 ± 0.0081 MPa, respectively. The nanoneedle and the cell have been assembled to measure the local stiffness of the single Saccharomyces cerevisiae cells The local stiffness, Young’s modulus and PZT output voltage of the three different size Saccharomyces cerevisiae have been determined at different environmental conditions. We investigated that, at low temperature the stiffness value is low to adapt to the change in the environmental condition. As a result, Saccharomyces cerevisiae becomes vulnerable to viral and bacterial attacks. Therefore, the proposed technique will serve as a quick and accurate process to diagnose diseases at early stage in a cell for effective treatment.
format Article
author Alsadat Rad, Maryam
Tijjani, Auwal Shehu
Ahmad, Mohd Ridzuan
Muhammad Auwal, Shehu
author_facet Alsadat Rad, Maryam
Tijjani, Auwal Shehu
Ahmad, Mohd Ridzuan
Muhammad Auwal, Shehu
author_sort Alsadat Rad, Maryam
title Finite element analysis of single cell stiffness measurements using PZT- integrated buckling nanoneedles
title_short Finite element analysis of single cell stiffness measurements using PZT- integrated buckling nanoneedles
title_full Finite element analysis of single cell stiffness measurements using PZT- integrated buckling nanoneedles
title_fullStr Finite element analysis of single cell stiffness measurements using PZT- integrated buckling nanoneedles
title_full_unstemmed Finite element analysis of single cell stiffness measurements using PZT- integrated buckling nanoneedles
title_sort finite element analysis of single cell stiffness measurements using pzt- integrated buckling nanoneedles
publisher MDPI AG
publishDate 2017
url http://eprints.utm.my/id/eprint/66475/
http://dx.doi.org/10.3390/s17010014
_version_ 1643655802757578752
score 13.211869

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