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Anti-inflammatory and anti-microbial activities of selected honey samples

The medical property of honey in wound healing was reported due to its anti-inflammatory and anti-microbial activities. It is believed that polar compounds including sugars and polyphenols in honey could contribute to the biological activities. In this study, crude honey samples of Tualang, Gelam an...

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Main Authors: Lee, Suan Chua, Mohd. Ismail, Nurul Izzati
Format: Article
Published: Academic Journals Inc. 2015
Subjects:
S Agriculture (General)
Online Access:http://eprints.utm.my/id/eprint/57833/
http://dx.doi.org/10.3923/ajar.2015.293.304
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spelling my.utm.578332021-08-22T08:43:53Z http://eprints.utm.my/id/eprint/57833/ Anti-inflammatory and anti-microbial activities of selected honey samples Lee, Suan Chua Mohd. Ismail, Nurul Izzati S Agriculture (General) The medical property of honey in wound healing was reported due to its anti-inflammatory and anti-microbial activities. It is believed that polar compounds including sugars and polyphenols in honey could contribute to the biological activities. In this study, crude honey samples of Tualang, Gelam and Acacia were fractionated into polar fractions using a C18 reversed-phase extraction column. The polar fractions were found to be more effective than crude honey samples because of lower effective concentration (0.04-0.37 g mL-1) at 50% of inhibition. However, the polar fractions did not improve the selectivity of inhibition against cyclooxygenase-2. Polar fractionation also did not improve the anti-microbial activities of crude honey samples. The improvement was only showed by Tualang honey fraction (~70%) with the minimum inhibitory concentration (3.1% (w/v)) against Candida albican. The potential bioactive compounds were putatively identified as hydroxymethylfurfural, ethyl glucuronide, myricetin and apigenin glycoside based on the results of LC-MS/MS. Academic Journals Inc. 2015 Article PeerReviewed Lee, Suan Chua and Mohd. Ismail, Nurul Izzati (2015) Anti-inflammatory and anti-microbial activities of selected honey samples. Asian Journal Of Agricultural Research, 9 (6). pp. 293-304. ISSN 1816-9503 http://dx.doi.org/10.3923/ajar.2015.293.304 DOI:10.3923/ajar.2015.293.304
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
topic S Agriculture (General)
spellingShingle S Agriculture (General)
Lee, Suan Chua
Mohd. Ismail, Nurul Izzati
Anti-inflammatory and anti-microbial activities of selected honey samples
description The medical property of honey in wound healing was reported due to its anti-inflammatory and anti-microbial activities. It is believed that polar compounds including sugars and polyphenols in honey could contribute to the biological activities. In this study, crude honey samples of Tualang, Gelam and Acacia were fractionated into polar fractions using a C18 reversed-phase extraction column. The polar fractions were found to be more effective than crude honey samples because of lower effective concentration (0.04-0.37 g mL-1) at 50% of inhibition. However, the polar fractions did not improve the selectivity of inhibition against cyclooxygenase-2. Polar fractionation also did not improve the anti-microbial activities of crude honey samples. The improvement was only showed by Tualang honey fraction (~70%) with the minimum inhibitory concentration (3.1% (w/v)) against Candida albican. The potential bioactive compounds were putatively identified as hydroxymethylfurfural, ethyl glucuronide, myricetin and apigenin glycoside based on the results of LC-MS/MS.
format Article
author Lee, Suan Chua
Mohd. Ismail, Nurul Izzati
author_facet Lee, Suan Chua
Mohd. Ismail, Nurul Izzati
author_sort Lee, Suan Chua
title Anti-inflammatory and anti-microbial activities of selected honey samples
title_short Anti-inflammatory and anti-microbial activities of selected honey samples
title_full Anti-inflammatory and anti-microbial activities of selected honey samples
title_fullStr Anti-inflammatory and anti-microbial activities of selected honey samples
title_full_unstemmed Anti-inflammatory and anti-microbial activities of selected honey samples
title_sort anti-inflammatory and anti-microbial activities of selected honey samples
publisher Academic Journals Inc.
publishDate 2015
url http://eprints.utm.my/id/eprint/57833/
http://dx.doi.org/10.3923/ajar.2015.293.304
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score 13.222552

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