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Electrokinetic extraction of doxorubicin from biological fluids by polymer inclusion membrane sampling probe

A polymer inclusion membrane (PIM) based sampling probe was developed for electrokinetic extraction of drugs from biological fluids. The probe was fabricated by dip-coating a nonconductive glass capillary tube in a homogeneous PIM solution for three cycles. The PIM solution comprised cellulose triac...

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Main Authors: Hui, Yin Tey, Breadmore, Michael C., Hong, Heng See
Format: Article
Published: American Chemical Society 2023
Subjects:
QD Chemistry
Online Access:http://eprints.utm.my/105011/
http://dx.doi.org/10.1021/acs.analchem.2c02937
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spelling my.utm.1050112024-04-01T07:45:18Z http://eprints.utm.my/105011/ Electrokinetic extraction of doxorubicin from biological fluids by polymer inclusion membrane sampling probe Hui, Yin Tey Breadmore, Michael C. Hong, Heng See QD Chemistry A polymer inclusion membrane (PIM) based sampling probe was developed for electrokinetic extraction of drugs from biological fluids. The probe was fabricated by dip-coating a nonconductive glass capillary tube in a homogeneous PIM solution for three cycles. The PIM solution comprised cellulose triacetate (CTA), 2-nitrophenyl octyl ether (NPOE), and 1-ethyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide [EMIM][NTf2] in a ratio of 5:4:2. The developed probe electrokinetically extracted doxorubicin from human plasma, human serum, and dried blood spot (DBS). The practicability and reliability of the electrokinetic extraction were evaluated by LC-MS/MS to quantify the desorption of extracted doxorubicin. Under the optimized conditions, a quantification limit of 0.2-2 ng/mL was achieved for the three biological samples. The probe was further integrated into a portable battery-powered device for safe low-voltage (36 V) electrokinetic extraction. The developed technique is envisioned to provide a more efficient analytical workflow in the laboratory. American Chemical Society 2023 Article PeerReviewed Hui, Yin Tey and Breadmore, Michael C. and Hong, Heng See (2023) Electrokinetic extraction of doxorubicin from biological fluids by polymer inclusion membrane sampling probe. Analytical Chemistry, 95 (4). pp. 2134-2139. ISSN 0003-2700 http://dx.doi.org/10.1021/acs.analchem.2c02937 DOI : 10.1021/acs.analchem.2c02937
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
topic QD Chemistry
spellingShingle QD Chemistry
Hui, Yin Tey
Breadmore, Michael C.
Hong, Heng See
Electrokinetic extraction of doxorubicin from biological fluids by polymer inclusion membrane sampling probe
description A polymer inclusion membrane (PIM) based sampling probe was developed for electrokinetic extraction of drugs from biological fluids. The probe was fabricated by dip-coating a nonconductive glass capillary tube in a homogeneous PIM solution for three cycles. The PIM solution comprised cellulose triacetate (CTA), 2-nitrophenyl octyl ether (NPOE), and 1-ethyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide [EMIM][NTf2] in a ratio of 5:4:2. The developed probe electrokinetically extracted doxorubicin from human plasma, human serum, and dried blood spot (DBS). The practicability and reliability of the electrokinetic extraction were evaluated by LC-MS/MS to quantify the desorption of extracted doxorubicin. Under the optimized conditions, a quantification limit of 0.2-2 ng/mL was achieved for the three biological samples. The probe was further integrated into a portable battery-powered device for safe low-voltage (36 V) electrokinetic extraction. The developed technique is envisioned to provide a more efficient analytical workflow in the laboratory.
format Article
author Hui, Yin Tey
Breadmore, Michael C.
Hong, Heng See
author_facet Hui, Yin Tey
Breadmore, Michael C.
Hong, Heng See
author_sort Hui, Yin Tey
title Electrokinetic extraction of doxorubicin from biological fluids by polymer inclusion membrane sampling probe
title_short Electrokinetic extraction of doxorubicin from biological fluids by polymer inclusion membrane sampling probe
title_full Electrokinetic extraction of doxorubicin from biological fluids by polymer inclusion membrane sampling probe
title_fullStr Electrokinetic extraction of doxorubicin from biological fluids by polymer inclusion membrane sampling probe
title_full_unstemmed Electrokinetic extraction of doxorubicin from biological fluids by polymer inclusion membrane sampling probe
title_sort electrokinetic extraction of doxorubicin from biological fluids by polymer inclusion membrane sampling probe
publisher American Chemical Society
publishDate 2023
url http://eprints.utm.my/105011/
http://dx.doi.org/10.1021/acs.analchem.2c02937
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score 13.211869

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