Curcumin-loaded electrospun poly(ɛ-caprolactone) nanofibrous membrane: an efficient and biocompatible wound-dressing material
The present study aims to produce a natural drug-incorporated nano-based wound-dressing material with high biocompatibility and enhanced antibacterial efficacy for promoting rapid wound healing. Electrospun curcumin-loaded poly(ɛ-caprolactone) (PCL/Cur) membrane is successfully fabricated and charac...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Published: |
Elsevier B. V.
2022
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| Subjects: | |
| Online Access: | http://eprints.utm.my/103008/ http://dx.doi.org/10.1016/j.matlet.2022.131910 |
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| Summary: | The present study aims to produce a natural drug-incorporated nano-based wound-dressing material with high biocompatibility and enhanced antibacterial efficacy for promoting rapid wound healing. Electrospun curcumin-loaded poly(ɛ-caprolactone) (PCL/Cur) membrane is successfully fabricated and characterized using standard techniques. The fabricated PCL/Cur membrane showed a higher antibacterial effect against the bacterial strains, Staphylococcus aureus and Escherichia coli; whereas, a very less cytotoxic effect was observed on the mouse fibroblast (L929) cells. This study concludes that PCL/Cur membrane could be a simple, biocompatible, and efficient material for wound-dressing applications. |
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