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Immune checkpoint molecules and glucose metabolism in HIV-induced T cell exhaustion

The progressive decline of CD8+ cytotoxic T cells in human immunodeficiency virus (HIV)-infected patients due to infection-triggered cell exhaustion and cell death is significantly correlated with disease severity and progression into the life-threatening acquired immunodeficiency syndrome (AIDS) st...

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Main Authors: Chan, Yee Teng, Cheong, Heng Choon, Tang, Ting Fang, Rajasuriar, Reena, Cheng, Kian-Kai, Looi, Chung Yeng, Wong, Won Fen, Kamarulzaman, Adeeba
Format: Article
Language:English
Published: MDPI 2022
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TP Chemical technology
Online Access:http://eprints.utm.my/id/eprint/101236/1/ChengKianKai2022_ImmuneCheckpointMoleculesandGlucoseMetabolism.pdf
http://eprints.utm.my/id/eprint/101236/
http://dx.doi.org/10.3390/biomedicines10112809
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spelling my.utm.1012362023-06-01T10:04:59Z http://eprints.utm.my/id/eprint/101236/ Immune checkpoint molecules and glucose metabolism in HIV-induced T cell exhaustion Chan, Yee Teng Cheong, Heng Choon Tang, Ting Fang Rajasuriar, Reena Cheng, Kian-Kai Looi, Chung Yeng Wong, Won Fen Kamarulzaman, Adeeba TP Chemical technology The progressive decline of CD8+ cytotoxic T cells in human immunodeficiency virus (HIV)-infected patients due to infection-triggered cell exhaustion and cell death is significantly correlated with disease severity and progression into the life-threatening acquired immunodeficiency syndrome (AIDS) stage. T cell exhaustion is a condition of cell dysfunction despite antigen engagement, characterized by augmented surface expression of immune checkpoint molecules such as programmed cell death protein 1 (PD-1), which suppress T cell receptor (TCR) signaling and negatively impact the proliferative and effector activities of T cells. T cell function is tightly modulated by cellular glucose metabolism, which produces adequate energy to support a robust reaction when battling pathogen infection. The transition of the T cells from an active to an exhausted state following pathogen persistence involves a drastic change in metabolic activity. This review highlights the interplay between immune checkpoint molecules and glucose metabolism that contributes to T cell exhaustion in the context of chronic HIV infection, which could deliver an insight into the rational design of a novel therapeutic strategy. MDPI 2022 Article PeerReviewed application/pdf en http://eprints.utm.my/id/eprint/101236/1/ChengKianKai2022_ImmuneCheckpointMoleculesandGlucoseMetabolism.pdf Chan, Yee Teng and Cheong, Heng Choon and Tang, Ting Fang and Rajasuriar, Reena and Cheng, Kian-Kai and Looi, Chung Yeng and Wong, Won Fen and Kamarulzaman, Adeeba (2022) Immune checkpoint molecules and glucose metabolism in HIV-induced T cell exhaustion. Biomedicines, 10 (11). pp. 1-18. ISSN 2227-9059 http://dx.doi.org/10.3390/biomedicines10112809 DOI : 10.3390/biomedicines10112809
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
language English
topic TP Chemical technology
spellingShingle TP Chemical technology
Chan, Yee Teng
Cheong, Heng Choon
Tang, Ting Fang
Rajasuriar, Reena
Cheng, Kian-Kai
Looi, Chung Yeng
Wong, Won Fen
Kamarulzaman, Adeeba
Immune checkpoint molecules and glucose metabolism in HIV-induced T cell exhaustion
description The progressive decline of CD8+ cytotoxic T cells in human immunodeficiency virus (HIV)-infected patients due to infection-triggered cell exhaustion and cell death is significantly correlated with disease severity and progression into the life-threatening acquired immunodeficiency syndrome (AIDS) stage. T cell exhaustion is a condition of cell dysfunction despite antigen engagement, characterized by augmented surface expression of immune checkpoint molecules such as programmed cell death protein 1 (PD-1), which suppress T cell receptor (TCR) signaling and negatively impact the proliferative and effector activities of T cells. T cell function is tightly modulated by cellular glucose metabolism, which produces adequate energy to support a robust reaction when battling pathogen infection. The transition of the T cells from an active to an exhausted state following pathogen persistence involves a drastic change in metabolic activity. This review highlights the interplay between immune checkpoint molecules and glucose metabolism that contributes to T cell exhaustion in the context of chronic HIV infection, which could deliver an insight into the rational design of a novel therapeutic strategy.
format Article
author Chan, Yee Teng
Cheong, Heng Choon
Tang, Ting Fang
Rajasuriar, Reena
Cheng, Kian-Kai
Looi, Chung Yeng
Wong, Won Fen
Kamarulzaman, Adeeba
author_facet Chan, Yee Teng
Cheong, Heng Choon
Tang, Ting Fang
Rajasuriar, Reena
Cheng, Kian-Kai
Looi, Chung Yeng
Wong, Won Fen
Kamarulzaman, Adeeba
author_sort Chan, Yee Teng
title Immune checkpoint molecules and glucose metabolism in HIV-induced T cell exhaustion
title_short Immune checkpoint molecules and glucose metabolism in HIV-induced T cell exhaustion
title_full Immune checkpoint molecules and glucose metabolism in HIV-induced T cell exhaustion
title_fullStr Immune checkpoint molecules and glucose metabolism in HIV-induced T cell exhaustion
title_full_unstemmed Immune checkpoint molecules and glucose metabolism in HIV-induced T cell exhaustion
title_sort immune checkpoint molecules and glucose metabolism in hiv-induced t cell exhaustion
publisher MDPI
publishDate 2022
url http://eprints.utm.my/id/eprint/101236/1/ChengKianKai2022_ImmuneCheckpointMoleculesandGlucoseMetabolism.pdf
http://eprints.utm.my/id/eprint/101236/
http://dx.doi.org/10.3390/biomedicines10112809
_version_ 1768006628420878336
score 13.211869

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