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Phytochemical contents and antioxidant properties of polyherbal effervescent tablets formulated with different effervescent agents

The production of effervescent tablets by using effervescent agents in pharmaceutical products has increased due to the convenient way of swallowing the tablets. The aim of this study was to formulate polyherbal extract of Phyllanthus niruri, Strobilanthes crispus and Orthosiphon aristatus...

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Main Authors: Mohd Sukri, Nurul Syafuhah, Muhammad, Norhayati, Abdul Rahim, Nur Fazira
Format: Article
Language:English
Published: 2022
Subjects:
T Technology (General)
Online Access:http://eprints.uthm.edu.my/7292/1/J14266_7e210dd44b24ae9a1fb45a3c306fe9c2%5B1%5D.pdf
http://eprints.uthm.edu.my/7292/
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spelling my.uthm.eprints.72922022-07-21T03:49:40Z http://eprints.uthm.edu.my/7292/ Phytochemical contents and antioxidant properties of polyherbal effervescent tablets formulated with different effervescent agents Mohd Sukri, Nurul Syafuhah Muhammad, Norhayati Abdul Rahim, Nur Fazira T Technology (General) The production of effervescent tablets by using effervescent agents in pharmaceutical products has increased due to the convenient way of swallowing the tablets. The aim of this study was to formulate polyherbal extract of Phyllanthus niruri, Strobilanthes crispus and Orthosiphon aristatus in effervescent tablets using different agents as well as to evaluate the phytochemical contents and antioxidant properties of those formulated tablets. Eight different types of formulated tablets were prepared with different effervescent agents. Total phenolic content (TPC), total flavonoid content (TFC), 2,2-diphenyl-1- picrylhydrazyl (DPPH) radical scavenging activity and ferric-reducing antioxidant power (FRAP) assays were used to evaluate the antioxidant properties of the formulated tablets. The effervescent tablet formulated with 20% acidic agent especially with citric acid (T1) displayed significant properties (p < 0.05) on phytochemical contents (TPC: 36.76 ± 0.50 mg GAE/g DW; TFC: 55.54 ± 3.60 mg RE/g DW) and antioxidant activities (DPPH: IC50: 61.60 ± 0.31 mg/mL; FRAP: 57.05 ± 0.98 mg Fe2+/g DW). In conclusion, the high content of acidic agents resulted in high phytochemical contents and antioxidant activities among the formulated polyherbal effervescent tablets. The application of effervescent agents in formulating polyherbal extract into fast-disintegrating tablets could offer opportunities in producing nutraceutical and oral drugs. 2022 Article PeerReviewed text en http://eprints.uthm.edu.my/7292/1/J14266_7e210dd44b24ae9a1fb45a3c306fe9c2%5B1%5D.pdf Mohd Sukri, Nurul Syafuhah and Muhammad, Norhayati and Abdul Rahim, Nur Fazira (2022) Phytochemical contents and antioxidant properties of polyherbal effervescent tablets formulated with different effervescent agents. Research Journal of Chemistry and Environment, 26 (3). pp. 1-7.
institution Universiti Tun Hussein Onn Malaysia
building UTHM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Tun Hussein Onn Malaysia
content_source UTHM Institutional Repository
url_provider http://eprints.uthm.edu.my/
language English
topic T Technology (General)
spellingShingle T Technology (General)
Mohd Sukri, Nurul Syafuhah
Muhammad, Norhayati
Abdul Rahim, Nur Fazira
Phytochemical contents and antioxidant properties of polyherbal effervescent tablets formulated with different effervescent agents
description The production of effervescent tablets by using effervescent agents in pharmaceutical products has increased due to the convenient way of swallowing the tablets. The aim of this study was to formulate polyherbal extract of Phyllanthus niruri, Strobilanthes crispus and Orthosiphon aristatus in effervescent tablets using different agents as well as to evaluate the phytochemical contents and antioxidant properties of those formulated tablets. Eight different types of formulated tablets were prepared with different effervescent agents. Total phenolic content (TPC), total flavonoid content (TFC), 2,2-diphenyl-1- picrylhydrazyl (DPPH) radical scavenging activity and ferric-reducing antioxidant power (FRAP) assays were used to evaluate the antioxidant properties of the formulated tablets. The effervescent tablet formulated with 20% acidic agent especially with citric acid (T1) displayed significant properties (p < 0.05) on phytochemical contents (TPC: 36.76 ± 0.50 mg GAE/g DW; TFC: 55.54 ± 3.60 mg RE/g DW) and antioxidant activities (DPPH: IC50: 61.60 ± 0.31 mg/mL; FRAP: 57.05 ± 0.98 mg Fe2+/g DW). In conclusion, the high content of acidic agents resulted in high phytochemical contents and antioxidant activities among the formulated polyherbal effervescent tablets. The application of effervescent agents in formulating polyherbal extract into fast-disintegrating tablets could offer opportunities in producing nutraceutical and oral drugs.
format Article
author Mohd Sukri, Nurul Syafuhah
Muhammad, Norhayati
Abdul Rahim, Nur Fazira
author_facet Mohd Sukri, Nurul Syafuhah
Muhammad, Norhayati
Abdul Rahim, Nur Fazira
author_sort Mohd Sukri, Nurul Syafuhah
title Phytochemical contents and antioxidant properties of polyherbal effervescent tablets formulated with different effervescent agents
title_short Phytochemical contents and antioxidant properties of polyherbal effervescent tablets formulated with different effervescent agents
title_full Phytochemical contents and antioxidant properties of polyherbal effervescent tablets formulated with different effervescent agents
title_fullStr Phytochemical contents and antioxidant properties of polyherbal effervescent tablets formulated with different effervescent agents
title_full_unstemmed Phytochemical contents and antioxidant properties of polyherbal effervescent tablets formulated with different effervescent agents
title_sort phytochemical contents and antioxidant properties of polyherbal effervescent tablets formulated with different effervescent agents
publishDate 2022
url http://eprints.uthm.edu.my/7292/1/J14266_7e210dd44b24ae9a1fb45a3c306fe9c2%5B1%5D.pdf
http://eprints.uthm.edu.my/7292/
_version_ 1739830437882101760
score 13.211869

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