Phytochemical contents and antioxidant properties of polyherbal effervescent tablets formulated with different effervescent agents
The production of effervescent tablets by using effervescent agents in pharmaceutical products has increased due to the convenient way of swallowing the tablets. The aim of this study was to formulate polyherbal extract of Phyllanthus niruri, Strobilanthes crispus and Orthosiphon aristatus...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
2022
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| Subjects: | |
| Online Access: | http://eprints.uthm.edu.my/7292/1/J14266_7e210dd44b24ae9a1fb45a3c306fe9c2%5B1%5D.pdf http://eprints.uthm.edu.my/7292/ |
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| Summary: | The production of effervescent tablets by using
effervescent agents in pharmaceutical products has
increased due to the convenient way of swallowing the
tablets. The aim of this study was to formulate
polyherbal extract of Phyllanthus niruri, Strobilanthes
crispus and Orthosiphon aristatus in effervescent
tablets using different agents as well as to evaluate the
phytochemical contents and antioxidant properties of
those formulated tablets. Eight different types of
formulated tablets were prepared with different
effervescent agents. Total phenolic content (TPC), total
flavonoid content (TFC), 2,2-diphenyl-1-
picrylhydrazyl (DPPH) radical scavenging activity and
ferric-reducing antioxidant power (FRAP) assays were
used to evaluate the antioxidant properties of the
formulated tablets.
The effervescent tablet formulated with 20% acidic
agent especially with citric acid (T1) displayed
significant properties (p < 0.05) on phytochemical
contents (TPC: 36.76 ± 0.50 mg GAE/g DW; TFC:
55.54 ± 3.60 mg RE/g DW) and antioxidant activities
(DPPH: IC50: 61.60 ± 0.31 mg/mL; FRAP: 57.05 ±
0.98 mg Fe2+/g DW). In conclusion, the high content of
acidic agents resulted in high phytochemical contents
and antioxidant activities among the formulated
polyherbal effervescent tablets. The application of
effervescent agents in formulating polyherbal extract
into fast-disintegrating tablets could offer
opportunities in producing nutraceutical and oral
drugs. |
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