A Facile Ionic Liquid Promoted Synthesis, Cholinesterase Inhibitory Activity and Molecular Modeling Study of Novel Highly Functionalized Spiropyrrolidines
A series of novel dimethoxyindanone embedded spiropyrrolidines were synthesized in ionic liquid, [bmim]Br and were evaluated for their inhibitory activities towards cholinesterases. Among the spiropyrrolidines, compound 4f exhibited the most potent activity with an IC50 value of 1.57 μM against ace...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI
2015
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| Subjects: | |
| Online Access: | http://eprints.usm.my/38014/1/A_Facile_Ionic_Liquid_Promoted_Synthesis%2C_Cholinesterase_Inhibitory.pdf http://eprints.usm.my/38014/ https://doi.org/10.3390/molecules20022296 |
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