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A Facile Ionic Liquid Promoted Synthesis, Cholinesterase Inhibitory Activity and Molecular Modeling Study of Novel Highly Functionalized Spiropyrrolidines

A series of novel dimethoxyindanone embedded spiropyrrolidines were synthesized in ionic liquid, [bmim]Br and were evaluated for their inhibitory activities towards cholinesterases. Among the spiropyrrolidines, compound 4f exhibited the most potent activity with an IC50 value of 1.57 μM against ace...

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Bibliographic Details
Main Authors: I. Almansour, Abdulrahman, Kumar, Raju Suresh, Arumugam, Natarajan, Basiri, Alireza, Kia, Yalda, Ali, Mohamed Ashraf, Farooq, Mehvish, Murugaiyah, Vikneswaran
Format: Article
Language:English
Published: MDPI 2015
Subjects:
QD1-999 Chemistry
R735-854 Medical education. Medical schools. Research
RS1-441 Pharmacy and materia medica
Online Access:http://eprints.usm.my/38014/1/A_Facile_Ionic_Liquid_Promoted_Synthesis%2C_Cholinesterase_Inhibitory.pdf
http://eprints.usm.my/38014/
https://doi.org/10.3390/molecules20022296
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http://eprints.usm.my/38014/1/A_Facile_Ionic_Liquid_Promoted_Synthesis%2C_Cholinesterase_Inhibitory.pdf
http://eprints.usm.my/38014/
https://doi.org/10.3390/molecules20022296

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