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Functional food mixtures: inhibition of lipid peroxidation, HMGCoA reductase, and ACAT2 in hypercholesterolemia‐induced rats

Mixtures of selected functional foods (MSFF) were composed of nattokinase (fermented soybean), red yeast rice extract, Ginkgo biloba, oat fiber, garlic, bee pollen, and propolis as anti‐hypercholesterolemic were studied. The goal of this study was to determine the bioactive compounds in these mixtur...

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Main Authors: Mohd Rosmi, Noor Syafiqa Aqila, Shafie, Nurul Husna, Azlan, Azrina, Abdullah, Maizaton Atmadini
Format: Article
Language:English
Published: John Wiley and Sons 2021
Online Access:http://psasir.upm.edu.my/id/eprint/97400/1/ABSTRACT.pdf
http://psasir.upm.edu.my/id/eprint/97400/
https://onlinelibrary.wiley.com/doi/10.1002/fsn3.2051
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spelling my.upm.eprints.974002022-08-26T08:07:45Z http://psasir.upm.edu.my/id/eprint/97400/ Functional food mixtures: inhibition of lipid peroxidation, HMGCoA reductase, and ACAT2 in hypercholesterolemia‐induced rats Mohd Rosmi, Noor Syafiqa Aqila Shafie, Nurul Husna Azlan, Azrina Abdullah, Maizaton Atmadini Mixtures of selected functional foods (MSFF) were composed of nattokinase (fermented soybean), red yeast rice extract, Ginkgo biloba, oat fiber, garlic, bee pollen, and propolis as anti‐hypercholesterolemic were studied. The goal of this study was to determine the bioactive compounds in these mixtures and their cholesterol‐lowering potential effects (biochemical profiles, lipid peroxidation, liver tissue histopathology, and enzymatic activity analysis; HMGCoA reductase and ACAT2. The LC‐MS/MS analysis showed that bioactive compounds such as Monacolin K, naringin, tocopherol, and glutamate, which have potential as anti‐hypercholesterolemic agents, were present in these functional food mixtures. MSFF supplementation at 50 mg/kg 100 mg/kg and 200 mg/kg showed substantial reductions in serum lipid profiles (TC and LDL) (p < .05). The serum liver profiles of AST (115.33 ± 8.69 U/L) and ALT (61.00 ± 1.00 U/L) were significantly reduced (p < .05) with MSFF supplementation at 200 mg/kg. MDA lipid peroxidation has also decreased significantly (p < .05) in serum (3.69 ± 0.42 μmol/L) and liver (15.04 ± 0.97 μmol/mg) tissues and has been shown to protect against hepatic steatosis. The significant (p < .05) inhibition activity of HMGCoA reductase (163.82 ± 3.50 pg/ml) and ACAT2 (348.35 ± 18.85 pg/ml) was also attributed by the supplementation of MSFF at 200 mg/kg. John Wiley and Sons 2021 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/97400/1/ABSTRACT.pdf Mohd Rosmi, Noor Syafiqa Aqila and Shafie, Nurul Husna and Azlan, Azrina and Abdullah, Maizaton Atmadini (2021) Functional food mixtures: inhibition of lipid peroxidation, HMGCoA reductase, and ACAT2 in hypercholesterolemia‐induced rats. Food Science & Nutrition, 9 (2). 875 - 887. ISSN 2048-7177 https://onlinelibrary.wiley.com/doi/10.1002/fsn3.2051 10.1002/fsn3.2051
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Mixtures of selected functional foods (MSFF) were composed of nattokinase (fermented soybean), red yeast rice extract, Ginkgo biloba, oat fiber, garlic, bee pollen, and propolis as anti‐hypercholesterolemic were studied. The goal of this study was to determine the bioactive compounds in these mixtures and their cholesterol‐lowering potential effects (biochemical profiles, lipid peroxidation, liver tissue histopathology, and enzymatic activity analysis; HMGCoA reductase and ACAT2. The LC‐MS/MS analysis showed that bioactive compounds such as Monacolin K, naringin, tocopherol, and glutamate, which have potential as anti‐hypercholesterolemic agents, were present in these functional food mixtures. MSFF supplementation at 50 mg/kg 100 mg/kg and 200 mg/kg showed substantial reductions in serum lipid profiles (TC and LDL) (p < .05). The serum liver profiles of AST (115.33 ± 8.69 U/L) and ALT (61.00 ± 1.00 U/L) were significantly reduced (p < .05) with MSFF supplementation at 200 mg/kg. MDA lipid peroxidation has also decreased significantly (p < .05) in serum (3.69 ± 0.42 μmol/L) and liver (15.04 ± 0.97 μmol/mg) tissues and has been shown to protect against hepatic steatosis. The significant (p < .05) inhibition activity of HMGCoA reductase (163.82 ± 3.50 pg/ml) and ACAT2 (348.35 ± 18.85 pg/ml) was also attributed by the supplementation of MSFF at 200 mg/kg.
format Article
author Mohd Rosmi, Noor Syafiqa Aqila
Shafie, Nurul Husna
Azlan, Azrina
Abdullah, Maizaton Atmadini
spellingShingle Mohd Rosmi, Noor Syafiqa Aqila
Shafie, Nurul Husna
Azlan, Azrina
Abdullah, Maizaton Atmadini
Functional food mixtures: inhibition of lipid peroxidation, HMGCoA reductase, and ACAT2 in hypercholesterolemia‐induced rats
author_facet Mohd Rosmi, Noor Syafiqa Aqila
Shafie, Nurul Husna
Azlan, Azrina
Abdullah, Maizaton Atmadini
author_sort Mohd Rosmi, Noor Syafiqa Aqila
title Functional food mixtures: inhibition of lipid peroxidation, HMGCoA reductase, and ACAT2 in hypercholesterolemia‐induced rats
title_short Functional food mixtures: inhibition of lipid peroxidation, HMGCoA reductase, and ACAT2 in hypercholesterolemia‐induced rats
title_full Functional food mixtures: inhibition of lipid peroxidation, HMGCoA reductase, and ACAT2 in hypercholesterolemia‐induced rats
title_fullStr Functional food mixtures: inhibition of lipid peroxidation, HMGCoA reductase, and ACAT2 in hypercholesterolemia‐induced rats
title_full_unstemmed Functional food mixtures: inhibition of lipid peroxidation, HMGCoA reductase, and ACAT2 in hypercholesterolemia‐induced rats
title_sort functional food mixtures: inhibition of lipid peroxidation, hmgcoa reductase, and acat2 in hypercholesterolemia‐induced rats
publisher John Wiley and Sons
publishDate 2021
url http://psasir.upm.edu.my/id/eprint/97400/1/ABSTRACT.pdf
http://psasir.upm.edu.my/id/eprint/97400/
https://onlinelibrary.wiley.com/doi/10.1002/fsn3.2051
_version_ 1743108549678989312
score 13.211869

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