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Interesterified palm olein lowers postprandial glucose-dependent insulinotropic polypeptide response in type 2 diabetes

Purpose: We aim to investigate the postprandial effects of palm olein (PO) and chemically interesterified palm olein (IPO) with different proportions of palmitic acid at the sn-2 position using high oleic sunflower oil (HOS) as control fat on concentrations of gut hormones, glucose homeostasis, sati...

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Main Authors: Mo, Shuen Yeing, Lai, Oi Ming, Chew, Boon How, Ismail, Ruhaini, Abu bakar, Sallehudin, Abdul Jabbar, Norli, Teng, Kim Tiu
Format: Article
Language:English
Published: Springer 2019
Online Access:http://psasir.upm.edu.my/id/eprint/80295/1/Interesterified%20palm%20olein%20lowers%20postprandial%20glucose-dependent%20insulinotropic%20polypeptide%20response%20in%20type%202%20diabetes.pdf
http://psasir.upm.edu.my/id/eprint/80295/
https://www.researchgate.net/publication/325587835_Interesterified_palm_olein_lowers_postprandial_glucose-dependent_insulinotropic_polypeptide_response_in_type_2_diabetes
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spelling my.upm.eprints.802952020-10-20T19:33:43Z http://psasir.upm.edu.my/id/eprint/80295/ Interesterified palm olein lowers postprandial glucose-dependent insulinotropic polypeptide response in type 2 diabetes Mo, Shuen Yeing Lai, Oi Ming Chew, Boon How Ismail, Ruhaini Abu bakar, Sallehudin Abdul Jabbar, Norli Teng, Kim Tiu Purpose: We aim to investigate the postprandial effects of palm olein (PO) and chemically interesterified palm olein (IPO) with different proportions of palmitic acid at the sn-2 position using high oleic sunflower oil (HOS) as control fat on concentrations of gut hormones, glucose homeostasis, satiety, lipid and inflammatory parameters in type 2 diabetic (T2D) subjects. Methods: Using a randomised double-blind crossover design, 21 (men = 6, women = 15) T2D subjects consumed test meals (3.65 MJ) consisting of a high fat muffin (containing 50 g test fats provided as PO, IPO or HOS) and a milkshake. Postprandial changes in gut hormones, glucose homeostasis, satiety, lipid and inflammatory parameters after meals were analysed. Some of the solid fractions of the IPO were removed and thus the fatty acid composition of the PO and IPO was not entirely equal (PO vs IPO: palmitate 39.8 vs 38.7; oleate 43.6 vs 45.1). PO, IPO and HOS contained 9.7, 38.9 and 0.2 g/100 g total fatty acids of palmitic acid at the sn-2 position, respectively. At 37 °C, IPO contained 4.2% SFC whereas PO and HOS were completely melted. Results: Our novel observation shows that the incremental area under curve (iAUC) 0-6 h of plasma GIP concentration was on average 16% lower following IPO meal compared with PO and HOS (P < 0.05) meals. Serum C-peptide concentrations exhibited a significant meal × gender interaction (P = 0.009). No differences between test meals were noted for other measurements. Conclusions: This study shows no adverse effect of interesterification on hormones associated with glucose homeostasis notably GLP-1 in T2D subjects. Springer 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/80295/1/Interesterified%20palm%20olein%20lowers%20postprandial%20glucose-dependent%20insulinotropic%20polypeptide%20response%20in%20type%202%20diabetes.pdf Mo, Shuen Yeing and Lai, Oi Ming and Chew, Boon How and Ismail, Ruhaini and Abu bakar, Sallehudin and Abdul Jabbar, Norli and Teng, Kim Tiu (2019) Interesterified palm olein lowers postprandial glucose-dependent insulinotropic polypeptide response in type 2 diabetes. European Journal of Nutrition, 58 (5). pp. 1873-1885. ISSN 1436-6207; ESSN: 1436-6215 https://www.researchgate.net/publication/325587835_Interesterified_palm_olein_lowers_postprandial_glucose-dependent_insulinotropic_polypeptide_response_in_type_2_diabetes 10.1007/s00394-018-1738-6
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Purpose: We aim to investigate the postprandial effects of palm olein (PO) and chemically interesterified palm olein (IPO) with different proportions of palmitic acid at the sn-2 position using high oleic sunflower oil (HOS) as control fat on concentrations of gut hormones, glucose homeostasis, satiety, lipid and inflammatory parameters in type 2 diabetic (T2D) subjects. Methods: Using a randomised double-blind crossover design, 21 (men = 6, women = 15) T2D subjects consumed test meals (3.65 MJ) consisting of a high fat muffin (containing 50 g test fats provided as PO, IPO or HOS) and a milkshake. Postprandial changes in gut hormones, glucose homeostasis, satiety, lipid and inflammatory parameters after meals were analysed. Some of the solid fractions of the IPO were removed and thus the fatty acid composition of the PO and IPO was not entirely equal (PO vs IPO: palmitate 39.8 vs 38.7; oleate 43.6 vs 45.1). PO, IPO and HOS contained 9.7, 38.9 and 0.2 g/100 g total fatty acids of palmitic acid at the sn-2 position, respectively. At 37 °C, IPO contained 4.2% SFC whereas PO and HOS were completely melted. Results: Our novel observation shows that the incremental area under curve (iAUC) 0-6 h of plasma GIP concentration was on average 16% lower following IPO meal compared with PO and HOS (P < 0.05) meals. Serum C-peptide concentrations exhibited a significant meal × gender interaction (P = 0.009). No differences between test meals were noted for other measurements. Conclusions: This study shows no adverse effect of interesterification on hormones associated with glucose homeostasis notably GLP-1 in T2D subjects.
format Article
author Mo, Shuen Yeing
Lai, Oi Ming
Chew, Boon How
Ismail, Ruhaini
Abu bakar, Sallehudin
Abdul Jabbar, Norli
Teng, Kim Tiu
spellingShingle Mo, Shuen Yeing
Lai, Oi Ming
Chew, Boon How
Ismail, Ruhaini
Abu bakar, Sallehudin
Abdul Jabbar, Norli
Teng, Kim Tiu
Interesterified palm olein lowers postprandial glucose-dependent insulinotropic polypeptide response in type 2 diabetes
author_facet Mo, Shuen Yeing
Lai, Oi Ming
Chew, Boon How
Ismail, Ruhaini
Abu bakar, Sallehudin
Abdul Jabbar, Norli
Teng, Kim Tiu
author_sort Mo, Shuen Yeing
title Interesterified palm olein lowers postprandial glucose-dependent insulinotropic polypeptide response in type 2 diabetes
title_short Interesterified palm olein lowers postprandial glucose-dependent insulinotropic polypeptide response in type 2 diabetes
title_full Interesterified palm olein lowers postprandial glucose-dependent insulinotropic polypeptide response in type 2 diabetes
title_fullStr Interesterified palm olein lowers postprandial glucose-dependent insulinotropic polypeptide response in type 2 diabetes
title_full_unstemmed Interesterified palm olein lowers postprandial glucose-dependent insulinotropic polypeptide response in type 2 diabetes
title_sort interesterified palm olein lowers postprandial glucose-dependent insulinotropic polypeptide response in type 2 diabetes
publisher Springer
publishDate 2019
url http://psasir.upm.edu.my/id/eprint/80295/1/Interesterified%20palm%20olein%20lowers%20postprandial%20glucose-dependent%20insulinotropic%20polypeptide%20response%20in%20type%202%20diabetes.pdf
http://psasir.upm.edu.my/id/eprint/80295/
https://www.researchgate.net/publication/325587835_Interesterified_palm_olein_lowers_postprandial_glucose-dependent_insulinotropic_polypeptide_response_in_type_2_diabetes
_version_ 1681490812467150848
score 13.211869

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