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Pre-emptive multimodal analgesia with tramadol and ketamine–lidocaine infusion for suppression of central sensitization in a dog model of ovariohysterectomy

Objectives: The effects of pre-emptive infusion of ketamine-lidocaine with tramadol on the suppression of central sensitization were investigated in a dog ovariohysterectomy model. Patients and methods: Twelve dogs were randomly assigned to two groups: ketamine-lidocaine-tramadol (KLT) and tramadol...

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Main Authors: Kaka, Ubedullah, Rahman, Nor Alimah, Abubakar, Adamu Abdul, Goh, Yong Meng, Fakurazi, Sharida, Omar, Mohamed Ariff, Chen, Hui Cheng
Format: Article
Language:English
Published: Dove Medical Press 2018
Online Access:http://psasir.upm.edu.my/id/eprint/73596/1/Pre-emptive%20multimodal%20analgesia%20with%20tramadol%20and%20ketamine%E2%80%93lidocaine%20infusion%20for%20suppression%20of%20central%20sensitization%20in%20a%20dog%20model%20of%20ovariohysterectomy.pdf
http://psasir.upm.edu.my/id/eprint/73596/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905489/pdf/jpr-11-743.pdf
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spelling my.upm.eprints.735962020-06-30T00:49:07Z http://psasir.upm.edu.my/id/eprint/73596/ Pre-emptive multimodal analgesia with tramadol and ketamine–lidocaine infusion for suppression of central sensitization in a dog model of ovariohysterectomy Kaka, Ubedullah Rahman, Nor Alimah Abubakar, Adamu Abdul Goh, Yong Meng Fakurazi, Sharida Omar, Mohamed Ariff Chen, Hui Cheng Objectives: The effects of pre-emptive infusion of ketamine-lidocaine with tramadol on the suppression of central sensitization were investigated in a dog ovariohysterectomy model. Patients and methods: Twelve dogs were randomly assigned to two groups: ketamine-lidocaine-tramadol (KLT) and tramadol (T) groups. Both groups received intravenous tramadol 4 mg/kg body weight as premedication. Immediately after induction, the KLT group received ketamine and lidocaine at 0.5 and 2 mg/kg loading dose, followed by continuous rate infusion of 50 and 100 µg/kg/min, respectively, for 2 hours. Dogs in T group received saline bolus and continuous rate infusion at equi-volume. Intraoperatively, hemodynamic responses to surgical stimulation were recorded, whereas postoperative pain was evaluated using an algometer and short form of the Glasgow composite measure pain scale. Results: Intraoperatively, hemodynamic responses to surgical stimulation were obtunded to a greater degree in KLT compared to T group. Postoperatively, the pain scores increased only for the first hour in KLT group, compared to 12 hours in T group. Mechanical thresholds at the abdomen decreased postoperatively between 12 and 60 hours in KLT group versus the entire 72 hours in T group. Thresholds at tibia and radius in both groups increased in the immediate 1 hour postoperatively, but decreased thereafter. Significant decrement of thresholds from baseline were detected in the tibia at 24, 42, and 60 hours in KLT group compared to 24-72 hours in T group, and in the radius between 36 and 48 hours in T group, but none in KLT group. Conclusion: Addition of pre-emptive ketamine-lidocaine infusion to single intravenous dose of tramadol enhanced attenuation of central sensitization and improved intra- and postoperative analgesia. Dove Medical Press 2018 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/73596/1/Pre-emptive%20multimodal%20analgesia%20with%20tramadol%20and%20ketamine%E2%80%93lidocaine%20infusion%20for%20suppression%20of%20central%20sensitization%20in%20a%20dog%20model%20of%20ovariohysterectomy.pdf Kaka, Ubedullah and Rahman, Nor Alimah and Abubakar, Adamu Abdul and Goh, Yong Meng and Fakurazi, Sharida and Omar, Mohamed Ariff and Chen, Hui Cheng (2018) Pre-emptive multimodal analgesia with tramadol and ketamine–lidocaine infusion for suppression of central sensitization in a dog model of ovariohysterectomy. Journal of Pain Research, 11. 743 - 752. ISSN ESSN: 1178-7090 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905489/pdf/jpr-11-743.pdf 10.2147/JPR.S152475
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Objectives: The effects of pre-emptive infusion of ketamine-lidocaine with tramadol on the suppression of central sensitization were investigated in a dog ovariohysterectomy model. Patients and methods: Twelve dogs were randomly assigned to two groups: ketamine-lidocaine-tramadol (KLT) and tramadol (T) groups. Both groups received intravenous tramadol 4 mg/kg body weight as premedication. Immediately after induction, the KLT group received ketamine and lidocaine at 0.5 and 2 mg/kg loading dose, followed by continuous rate infusion of 50 and 100 µg/kg/min, respectively, for 2 hours. Dogs in T group received saline bolus and continuous rate infusion at equi-volume. Intraoperatively, hemodynamic responses to surgical stimulation were recorded, whereas postoperative pain was evaluated using an algometer and short form of the Glasgow composite measure pain scale. Results: Intraoperatively, hemodynamic responses to surgical stimulation were obtunded to a greater degree in KLT compared to T group. Postoperatively, the pain scores increased only for the first hour in KLT group, compared to 12 hours in T group. Mechanical thresholds at the abdomen decreased postoperatively between 12 and 60 hours in KLT group versus the entire 72 hours in T group. Thresholds at tibia and radius in both groups increased in the immediate 1 hour postoperatively, but decreased thereafter. Significant decrement of thresholds from baseline were detected in the tibia at 24, 42, and 60 hours in KLT group compared to 24-72 hours in T group, and in the radius between 36 and 48 hours in T group, but none in KLT group. Conclusion: Addition of pre-emptive ketamine-lidocaine infusion to single intravenous dose of tramadol enhanced attenuation of central sensitization and improved intra- and postoperative analgesia.
format Article
author Kaka, Ubedullah
Rahman, Nor Alimah
Abubakar, Adamu Abdul
Goh, Yong Meng
Fakurazi, Sharida
Omar, Mohamed Ariff
Chen, Hui Cheng
spellingShingle Kaka, Ubedullah
Rahman, Nor Alimah
Abubakar, Adamu Abdul
Goh, Yong Meng
Fakurazi, Sharida
Omar, Mohamed Ariff
Chen, Hui Cheng
Pre-emptive multimodal analgesia with tramadol and ketamine–lidocaine infusion for suppression of central sensitization in a dog model of ovariohysterectomy
author_facet Kaka, Ubedullah
Rahman, Nor Alimah
Abubakar, Adamu Abdul
Goh, Yong Meng
Fakurazi, Sharida
Omar, Mohamed Ariff
Chen, Hui Cheng
author_sort Kaka, Ubedullah
title Pre-emptive multimodal analgesia with tramadol and ketamine–lidocaine infusion for suppression of central sensitization in a dog model of ovariohysterectomy
title_short Pre-emptive multimodal analgesia with tramadol and ketamine–lidocaine infusion for suppression of central sensitization in a dog model of ovariohysterectomy
title_full Pre-emptive multimodal analgesia with tramadol and ketamine–lidocaine infusion for suppression of central sensitization in a dog model of ovariohysterectomy
title_fullStr Pre-emptive multimodal analgesia with tramadol and ketamine–lidocaine infusion for suppression of central sensitization in a dog model of ovariohysterectomy
title_full_unstemmed Pre-emptive multimodal analgesia with tramadol and ketamine–lidocaine infusion for suppression of central sensitization in a dog model of ovariohysterectomy
title_sort pre-emptive multimodal analgesia with tramadol and ketamine–lidocaine infusion for suppression of central sensitization in a dog model of ovariohysterectomy
publisher Dove Medical Press
publishDate 2018
url http://psasir.upm.edu.my/id/eprint/73596/1/Pre-emptive%20multimodal%20analgesia%20with%20tramadol%20and%20ketamine%E2%80%93lidocaine%20infusion%20for%20suppression%20of%20central%20sensitization%20in%20a%20dog%20model%20of%20ovariohysterectomy.pdf
http://psasir.upm.edu.my/id/eprint/73596/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905489/pdf/jpr-11-743.pdf
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score 13.211869

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