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Antihyperglycemic and anti-inflammatory effects of fermented food paste on high-fat diet and streptozotocin-challenged mice

Background: Fermented food has been widely consumed as health food to ameliorate or prevent several chronic diseases including diabetes. Xeniji™, a fermented food paste (FFP), has been previously reported with various bioactivities, which may be caused by the presence of several metabolites includin...

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Main Authors: Mohammed Alitheen, Noorjahan Banu, Zamberi, Nur Rizi, Tan, Sheau Wei, Zulkawi, Noraisyah, Kam, Heng Ng, Swee, Keong Yeap, Satharasinghe, Dilan Amila, Wan, Yong Ho, Abd Rashid, Nur Yuhasliza, Md Lazim, Mohd Izwan, Jamaluddin, Anisah, Long, Kamariah
Format: Article
Language:English
Published: Dove Medical Press 2018
Online Access:http://psasir.upm.edu.my/id/eprint/73158/1/FAT.pdf
http://psasir.upm.edu.my/id/eprint/73158/
https://www.dovepress.com/antihyperglycemic-and-anti-inflammatory-effects-of-fermented-food-past-peer-reviewed-article-DDDT
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spelling my.upm.eprints.731582021-01-26T20:02:56Z http://psasir.upm.edu.my/id/eprint/73158/ Antihyperglycemic and anti-inflammatory effects of fermented food paste on high-fat diet and streptozotocin-challenged mice Mohammed Alitheen, Noorjahan Banu Zamberi, Nur Rizi Tan, Sheau Wei Zulkawi, Noraisyah Kam, Heng Ng Swee, Keong Yeap Satharasinghe, Dilan Amila Wan, Yong Ho Abd Rashid, Nur Yuhasliza Md Lazim, Mohd Izwan Jamaluddin, Anisah Long, Kamariah Background: Fermented food has been widely consumed as health food to ameliorate or prevent several chronic diseases including diabetes. Xeniji™, a fermented food paste (FFP), has been previously reported with various bioactivities, which may be caused by the presence of several metabolites including polyphenolic acids, flavonoids, and vitamins. In this study, the anti-hyperglycemic and anti-inflammatory effects of FFP were assessed. Methods: In this study, type 2 diabetes model mice were induced by streptozotocin and high-fat diet (HFD) and used to evaluate the antihyperglycemic and anti-inflammatory effects of FFP. Mice were fed with HFD and challenged with 30 mg/kg body weight (BW) of streptozotocin for 1 month followed by 6 weeks of supplementation with 0.1 and 1.0 g/kg BW of FFP. Metformin was used as positive control treatment. Results: Xeniji™-supplemented hyperglycemic mice were recorded with lower glucose level after 6 weeks of duration. This effect was contributed by the improvement of insulin sensitivity in the hyperglycemic mice indicated by the oral glucose tolerance test, insulin tolerance test, and end point insulin level. In addition, gene expression study has shown that the antihyperglycemic effect of FFP is related to the improvement of lipid and glucose metabolism in the mice. Furthermore, both 0.1 and 1 g/kg BW of FFP was able to reduce hyperglycemia-related inflammation indicated by the reduction of proinflammatory cytokines, NF-kB and iNOS gene expression and nitric oxide level. Conclusion: FFP potentially demonstrated in vivo antihyperglycemic and anti-inflammatory effects on HFD and streptozotocin-induced diabetic mice. Dove Medical Press 2018 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/73158/1/FAT.pdf Mohammed Alitheen, Noorjahan Banu and Zamberi, Nur Rizi and Tan, Sheau Wei and Zulkawi, Noraisyah and Kam, Heng Ng and Swee, Keong Yeap and Satharasinghe, Dilan Amila and Wan, Yong Ho and Abd Rashid, Nur Yuhasliza and Md Lazim, Mohd Izwan and Jamaluddin, Anisah and Long, Kamariah (2018) Antihyperglycemic and anti-inflammatory effects of fermented food paste on high-fat diet and streptozotocin-challenged mice. Drug Design Development and Therapy, 12. 1373 - 1383. ISSN 1177-8881 https://www.dovepress.com/antihyperglycemic-and-anti-inflammatory-effects-of-fermented-food-past-peer-reviewed-article-DDDT 10.2147/DDDT.S157803
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Background: Fermented food has been widely consumed as health food to ameliorate or prevent several chronic diseases including diabetes. Xeniji™, a fermented food paste (FFP), has been previously reported with various bioactivities, which may be caused by the presence of several metabolites including polyphenolic acids, flavonoids, and vitamins. In this study, the anti-hyperglycemic and anti-inflammatory effects of FFP were assessed. Methods: In this study, type 2 diabetes model mice were induced by streptozotocin and high-fat diet (HFD) and used to evaluate the antihyperglycemic and anti-inflammatory effects of FFP. Mice were fed with HFD and challenged with 30 mg/kg body weight (BW) of streptozotocin for 1 month followed by 6 weeks of supplementation with 0.1 and 1.0 g/kg BW of FFP. Metformin was used as positive control treatment. Results: Xeniji™-supplemented hyperglycemic mice were recorded with lower glucose level after 6 weeks of duration. This effect was contributed by the improvement of insulin sensitivity in the hyperglycemic mice indicated by the oral glucose tolerance test, insulin tolerance test, and end point insulin level. In addition, gene expression study has shown that the antihyperglycemic effect of FFP is related to the improvement of lipid and glucose metabolism in the mice. Furthermore, both 0.1 and 1 g/kg BW of FFP was able to reduce hyperglycemia-related inflammation indicated by the reduction of proinflammatory cytokines, NF-kB and iNOS gene expression and nitric oxide level. Conclusion: FFP potentially demonstrated in vivo antihyperglycemic and anti-inflammatory effects on HFD and streptozotocin-induced diabetic mice.
format Article
author Mohammed Alitheen, Noorjahan Banu
Zamberi, Nur Rizi
Tan, Sheau Wei
Zulkawi, Noraisyah
Kam, Heng Ng
Swee, Keong Yeap
Satharasinghe, Dilan Amila
Wan, Yong Ho
Abd Rashid, Nur Yuhasliza
Md Lazim, Mohd Izwan
Jamaluddin, Anisah
Long, Kamariah
spellingShingle Mohammed Alitheen, Noorjahan Banu
Zamberi, Nur Rizi
Tan, Sheau Wei
Zulkawi, Noraisyah
Kam, Heng Ng
Swee, Keong Yeap
Satharasinghe, Dilan Amila
Wan, Yong Ho
Abd Rashid, Nur Yuhasliza
Md Lazim, Mohd Izwan
Jamaluddin, Anisah
Long, Kamariah
Antihyperglycemic and anti-inflammatory effects of fermented food paste on high-fat diet and streptozotocin-challenged mice
author_facet Mohammed Alitheen, Noorjahan Banu
Zamberi, Nur Rizi
Tan, Sheau Wei
Zulkawi, Noraisyah
Kam, Heng Ng
Swee, Keong Yeap
Satharasinghe, Dilan Amila
Wan, Yong Ho
Abd Rashid, Nur Yuhasliza
Md Lazim, Mohd Izwan
Jamaluddin, Anisah
Long, Kamariah
author_sort Mohammed Alitheen, Noorjahan Banu
title Antihyperglycemic and anti-inflammatory effects of fermented food paste on high-fat diet and streptozotocin-challenged mice
title_short Antihyperglycemic and anti-inflammatory effects of fermented food paste on high-fat diet and streptozotocin-challenged mice
title_full Antihyperglycemic and anti-inflammatory effects of fermented food paste on high-fat diet and streptozotocin-challenged mice
title_fullStr Antihyperglycemic and anti-inflammatory effects of fermented food paste on high-fat diet and streptozotocin-challenged mice
title_full_unstemmed Antihyperglycemic and anti-inflammatory effects of fermented food paste on high-fat diet and streptozotocin-challenged mice
title_sort antihyperglycemic and anti-inflammatory effects of fermented food paste on high-fat diet and streptozotocin-challenged mice
publisher Dove Medical Press
publishDate 2018
url http://psasir.upm.edu.my/id/eprint/73158/1/FAT.pdf
http://psasir.upm.edu.my/id/eprint/73158/
https://www.dovepress.com/antihyperglycemic-and-anti-inflammatory-effects-of-fermented-food-past-peer-reviewed-article-DDDT
_version_ 1690372565157019648
score 13.211869

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