Analysis of essential gene changes in MRSA and non-MRSA strains inhibited by methanolic extract correlated to membrane permeabilising peptide
In this study, a methanolic extract derived from a marine organism was investigated for the effect on the growth of MRSA resistant to b-lactam antibiotics. The nucleotide sequence changes of essential genes inclusive of mecA, mecR1, 16sRNA, mprF and msR of the inhibited MRSA strains were determined...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2007
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| Online Access: | http://psasir.upm.edu.my/id/eprint/7269/ http://dx.doi.org/10.1016/S0924-8579(07)72030-7 |
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| Summary: | In this study, a methanolic extract derived from a marine
organism was investigated for the effect on the growth of MRSA resistant to b-lactam antibiotics. The nucleotide sequence changes of essential genes inclusive of mecA, mecR1, 16sRNA, mprF and msR of the inhibited MRSA strains were determined. A potential antibacterial peptide with activity on permeabilising the membrane of MRSA strains
was investigated through a cellular bioassay. |
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