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Anti-Bacillus and nitric oxide inhibitory activities of Malaysian Garcinia mangostana extracts and their major constituents

Four types of crude extracts were obtained from the stem bark of Garcinia mangostana from which six xanthone derivatives: α-mangostin, β-mangostin, garcinone D, mangostenol, fuscaxanthone C and dulcisxanthone F were isolated. The structures of these compounds were elucidated and determined using spe...

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Main Authors: Karunakaran, Thiruventhan, Ismail, Intan Safinar, Ee, Gwendoline Cheng Lian
Format: Article
Language:English
Published: Faculty of Food Science and Technology, Universiti Putra Malaysia 2019
Online Access:http://psasir.upm.edu.my/id/eprint/68877/1/%2837%29.pdf
http://psasir.upm.edu.my/id/eprint/68877/
http://www.ifrj.upm.edu.my/26%20(02)%202019/(37).pdf
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spelling my.upm.eprints.688772019-06-11T02:02:18Z http://psasir.upm.edu.my/id/eprint/68877/ Anti-Bacillus and nitric oxide inhibitory activities of Malaysian Garcinia mangostana extracts and their major constituents Karunakaran, Thiruventhan Ismail, Intan Safinar Ee, Gwendoline Cheng Lian Four types of crude extracts were obtained from the stem bark of Garcinia mangostana from which six xanthone derivatives: α-mangostin, β-mangostin, garcinone D, mangostenol, fuscaxanthone C and dulcisxanthone F were isolated. The structures of these compounds were elucidated and determined using spectroscopic techniques such as MS, 1D and 2D NMR. The in vitro anti-Bacillus assay was performed using the crude extracts as well as α-mangostin and β-mangostin against four Bacillus species; B. subtilis ATCC 6633, B. cereus ATCC 33019, B. megaterium ATCC 14581 and B. pumilus ATCC 14884. The ethyl acetate extract showed strong inhibitory activity against B. subtilis, B. cereus, B. megaterium and B. pumilus in disc diffusion assay with 10.33 ± 0.44 mm, 10.33 ± 0.44 mm, 9.00 ± 0.00 mm and 11.33 ± 0.17 mm inhibition zones, respectively. Nitric oxide inhibition activities indicated that two major compounds (α-mangostin, β-mangostin) exhibited very significant activity in the inhibition of LPS/IFN-γ stimulated RAW 264.7 macrophages with IC50 values of 29.81 ± 0.77 and 11.72 ± 1.16 μM, respectively. The chloroform and ethyl acetate extract of G. mangostana showed very potent activities. Faculty of Food Science and Technology, Universiti Putra Malaysia 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/68877/1/%2837%29.pdf Karunakaran, Thiruventhan and Ismail, Intan Safinar and Ee, Gwendoline Cheng Lian (2019) Anti-Bacillus and nitric oxide inhibitory activities of Malaysian Garcinia mangostana extracts and their major constituents. International Food Research Journal, 26 (2). pp. 705-711. ISSN 1985-4668; ESSN: 2231-7546 http://www.ifrj.upm.edu.my/26%20(02)%202019/(37).pdf
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Four types of crude extracts were obtained from the stem bark of Garcinia mangostana from which six xanthone derivatives: α-mangostin, β-mangostin, garcinone D, mangostenol, fuscaxanthone C and dulcisxanthone F were isolated. The structures of these compounds were elucidated and determined using spectroscopic techniques such as MS, 1D and 2D NMR. The in vitro anti-Bacillus assay was performed using the crude extracts as well as α-mangostin and β-mangostin against four Bacillus species; B. subtilis ATCC 6633, B. cereus ATCC 33019, B. megaterium ATCC 14581 and B. pumilus ATCC 14884. The ethyl acetate extract showed strong inhibitory activity against B. subtilis, B. cereus, B. megaterium and B. pumilus in disc diffusion assay with 10.33 ± 0.44 mm, 10.33 ± 0.44 mm, 9.00 ± 0.00 mm and 11.33 ± 0.17 mm inhibition zones, respectively. Nitric oxide inhibition activities indicated that two major compounds (α-mangostin, β-mangostin) exhibited very significant activity in the inhibition of LPS/IFN-γ stimulated RAW 264.7 macrophages with IC50 values of 29.81 ± 0.77 and 11.72 ± 1.16 μM, respectively. The chloroform and ethyl acetate extract of G. mangostana showed very potent activities.
format Article
author Karunakaran, Thiruventhan
Ismail, Intan Safinar
Ee, Gwendoline Cheng Lian
spellingShingle Karunakaran, Thiruventhan
Ismail, Intan Safinar
Ee, Gwendoline Cheng Lian
Anti-Bacillus and nitric oxide inhibitory activities of Malaysian Garcinia mangostana extracts and their major constituents
author_facet Karunakaran, Thiruventhan
Ismail, Intan Safinar
Ee, Gwendoline Cheng Lian
author_sort Karunakaran, Thiruventhan
title Anti-Bacillus and nitric oxide inhibitory activities of Malaysian Garcinia mangostana extracts and their major constituents
title_short Anti-Bacillus and nitric oxide inhibitory activities of Malaysian Garcinia mangostana extracts and their major constituents
title_full Anti-Bacillus and nitric oxide inhibitory activities of Malaysian Garcinia mangostana extracts and their major constituents
title_fullStr Anti-Bacillus and nitric oxide inhibitory activities of Malaysian Garcinia mangostana extracts and their major constituents
title_full_unstemmed Anti-Bacillus and nitric oxide inhibitory activities of Malaysian Garcinia mangostana extracts and their major constituents
title_sort anti-bacillus and nitric oxide inhibitory activities of malaysian garcinia mangostana extracts and their major constituents
publisher Faculty of Food Science and Technology, Universiti Putra Malaysia
publishDate 2019
url http://psasir.upm.edu.my/id/eprint/68877/1/%2837%29.pdf
http://psasir.upm.edu.my/id/eprint/68877/
http://www.ifrj.upm.edu.my/26%20(02)%202019/(37).pdf
_version_ 1643839333115887616
score 13.211869

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