Emulsion formulation optimization and characterization of spray-dried k-carrageenan micropeprintss for the encapsulation of CoQ10
The present study is aimed to prepare κ-carrageenan microparticles for the encapsulation of model drug, coenzyme Q10 (CoQ10). A face-centered central composite design was employed to study the effects of three different formulation variables (κ-carrageenan, emulsifier, and oil). The powder yield was...
محفوظ في:
| المؤلفون الرئيسيون: | , , , , , |
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| التنسيق: | مقال |
| اللغة: | English |
| منشور في: |
Korean Society of Food Science and Technology
2016
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| الوصول للمادة أونلاين: | http://psasir.upm.edu.my/id/eprint/54152/1/Emulsion%20formulation%20optimization%20and%20characterization%20of%20spray-dried%20%CE%BA-carrageenan%20microparticles%20for%20the%20encapsulation%20of%20CoQ10.pdf http://psasir.upm.edu.my/id/eprint/54152/ https://link.springer.com/article/10.1007/s10068-016-0098-3 |
| الوسوم: |
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| الملخص: | The present study is aimed to prepare κ-carrageenan microparticles for the encapsulation of model drug, coenzyme Q10 (CoQ10). A face-centered central composite design was employed to study the effects of three different formulation variables (κ-carrageenan, emulsifier, and oil). The powder yield was found inversely affected by the κ-carrageenan and oil concentration. The encapsulation efficiency was maximized in the region of the middle level κ-carrageenan concentration, the high level emulsifier concentration, and the low level oil concentration. The emulsifier concentration was the most influential variable on the particle size of powder. The optimal formulation was reported as 0.91% (w/v) κ-carrageenan concentration, 0.64% (w/v) emulsifier, and 1.0% (w/w) oil. Both differential scanning colorimeter and X-ray diffraction analyses proved that incorporation of CoQ10 into κ- carrageenan microcapsules resulted in amorphous powder with significantly (p<0.05) higher water solubility compared to pure CoQ10 and physical mixture in the crystalline form. |
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