Staff View: Effect of supplementation of fermented milk drink containing probiotic Lactobacillus casei Shirota on the concentrations of aflatoxin biomarkers among employees of Universiti Putra Malaysia

Effect of supplementation of fermented milk drink containing probiotic Lactobacillus casei Shirota on the concentrations of aflatoxin biomarkers among employees of Universiti Putra Malaysia

Human exposure to aflatoxin is through the diet, and probiotics are able to bind aflatoxin and prevent its absorption in the small intestine. This study aimed to determine the effectiveness of a fermented milk drink containing Lactobacillus casei Shirota (LcS) (probiotic drink) to prevent aflatoxin...

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Main Authors:	Sabran, Mohd Redzwan, Abd Mutalib, Mohd Sokhini, Wang, Jia Sheng, Ahmad, Zuraini, Kang, Min Su, Abdul Rahman, Nurul 'Aqilah, Nasrabadi, Elham Nikbakht, Jamaluddin, Rosita
Format:	Article
Language:	English
Published:	Cambridge University Press 2016
Online Access:	http://psasir.upm.edu.my/id/eprint/54055/1/Effect%20of%20supplementation%20of%20fermented%20milk%20drink%20containing%20probiotic%20Lactobacillus%20.pdf http://psasir.upm.edu.my/id/eprint/54055/ https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/effect-of-supplementation-of-fermented-milk-drink-containing-probiotic-lactobacillus-casei-shirota-on-the-concentrations-of-aflatoxin-biomarkers-among-employees-of-universiti-put
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spelling	my.upm.eprints.540552018-02-27T02:12:13Z http://psasir.upm.edu.my/id/eprint/54055/ Effect of supplementation of fermented milk drink containing probiotic Lactobacillus casei Shirota on the concentrations of aflatoxin biomarkers among employees of Universiti Putra Malaysia Sabran, Mohd Redzwan Abd Mutalib, Mohd Sokhini Wang, Jia Sheng Ahmad, Zuraini Kang, Min Su Abdul Rahman, Nurul 'Aqilah Nasrabadi, Elham Nikbakht Jamaluddin, Rosita Human exposure to aflatoxin is through the diet, and probiotics are able to bind aflatoxin and prevent its absorption in the small intestine. This study aimed to determine the effectiveness of a fermented milk drink containing Lactobacillus casei Shirota (LcS) (probiotic drink) to prevent aflatoxin absorption and reduce serum aflatoxin B1-lysine adduct (AFB1-lys) and urinary aflatoxin M1 concentrations. The present study was a randomised, double-blind, cross-over, placebo-controlled study with two 4-week intervention phases. In all, seventy-one subjects recruited from the screening stage were divided into two groups--the Yellow group and the Blue group. In the 1st phase, one group received probiotic drinks twice a day and the other group received placebo drinks. Blood and urine samples were collected at baseline, 2nd and 4th week of the intervention. After a 2-week wash-out period, the treatments were switched between the groups, and blood and urine samples were collected at the 6th, 8th and 10th week (2nd phase) of the intervention. No significant differences in aflatoxin biomarker concentrations were observed during the intervention. A within-group analysis was further carried out. Aflatoxin biomarker concentrations were not significantly different in the Yellow group. Nevertheless, ANOVA for repeated measurements indicated that AFB1-lys concentrations were significantly different (P=0·035) with the probiotic intervention in the Blue group. The 2nd week AFB1-lys concentrations (5·14 (SD 2·15) pg/mg albumin (ALB)) were significantly reduced (P=0·048) compared with the baseline (6·24 (SD 3·42) pg/mg ALB). Besides, the 4th week AFB1-lys concentrations were significantly lower (P<0·05) with probiotic supplementation than with the placebo. Based on these findings, a longer intervention study is warranted to investigate the effects of continuous LcS consumption to prevent dietary aflatoxin exposure. Cambridge University Press 2016 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/54055/1/Effect%20of%20supplementation%20of%20fermented%20milk%20drink%20containing%20probiotic%20Lactobacillus%20.pdf Sabran, Mohd Redzwan and Abd Mutalib, Mohd Sokhini and Wang, Jia Sheng and Ahmad, Zuraini and Kang, Min Su and Abdul Rahman, Nurul 'Aqilah and Nasrabadi, Elham Nikbakht and Jamaluddin, Rosita (2016) Effect of supplementation of fermented milk drink containing probiotic Lactobacillus casei Shirota on the concentrations of aflatoxin biomarkers among employees of Universiti Putra Malaysia. British Journal of Nutrition, 115. pp. 39-54. ISSN 0007-1145; ESSN: 1475-2662 https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/effect-of-supplementation-of-fermented-milk-drink-containing-probiotic-lactobacillus-casei-shirota-on-the-concentrations-of-aflatoxin-biomarkers-among-employees-of-universiti-put 10.1017/S0007114515004109
institution	Universiti Putra Malaysia
building	UPM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Putra Malaysia
content_source	UPM Institutional Repository
url_provider	http://psasir.upm.edu.my/
language	English
description	Human exposure to aflatoxin is through the diet, and probiotics are able to bind aflatoxin and prevent its absorption in the small intestine. This study aimed to determine the effectiveness of a fermented milk drink containing Lactobacillus casei Shirota (LcS) (probiotic drink) to prevent aflatoxin absorption and reduce serum aflatoxin B1-lysine adduct (AFB1-lys) and urinary aflatoxin M1 concentrations. The present study was a randomised, double-blind, cross-over, placebo-controlled study with two 4-week intervention phases. In all, seventy-one subjects recruited from the screening stage were divided into two groups--the Yellow group and the Blue group. In the 1st phase, one group received probiotic drinks twice a day and the other group received placebo drinks. Blood and urine samples were collected at baseline, 2nd and 4th week of the intervention. After a 2-week wash-out period, the treatments were switched between the groups, and blood and urine samples were collected at the 6th, 8th and 10th week (2nd phase) of the intervention. No significant differences in aflatoxin biomarker concentrations were observed during the intervention. A within-group analysis was further carried out. Aflatoxin biomarker concentrations were not significantly different in the Yellow group. Nevertheless, ANOVA for repeated measurements indicated that AFB1-lys concentrations were significantly different (P=0·035) with the probiotic intervention in the Blue group. The 2nd week AFB1-lys concentrations (5·14 (SD 2·15) pg/mg albumin (ALB)) were significantly reduced (P=0·048) compared with the baseline (6·24 (SD 3·42) pg/mg ALB). Besides, the 4th week AFB1-lys concentrations were significantly lower (P<0·05) with probiotic supplementation than with the placebo. Based on these findings, a longer intervention study is warranted to investigate the effects of continuous LcS consumption to prevent dietary aflatoxin exposure.
format	Article
author	Sabran, Mohd Redzwan Abd Mutalib, Mohd Sokhini Wang, Jia Sheng Ahmad, Zuraini Kang, Min Su Abdul Rahman, Nurul 'Aqilah Nasrabadi, Elham Nikbakht Jamaluddin, Rosita
spellingShingle	Sabran, Mohd Redzwan Abd Mutalib, Mohd Sokhini Wang, Jia Sheng Ahmad, Zuraini Kang, Min Su Abdul Rahman, Nurul 'Aqilah Nasrabadi, Elham Nikbakht Jamaluddin, Rosita Effect of supplementation of fermented milk drink containing probiotic Lactobacillus casei Shirota on the concentrations of aflatoxin biomarkers among employees of Universiti Putra Malaysia
author_facet	Sabran, Mohd Redzwan Abd Mutalib, Mohd Sokhini Wang, Jia Sheng Ahmad, Zuraini Kang, Min Su Abdul Rahman, Nurul 'Aqilah Nasrabadi, Elham Nikbakht Jamaluddin, Rosita
author_sort	Sabran, Mohd Redzwan
title	Effect of supplementation of fermented milk drink containing probiotic Lactobacillus casei Shirota on the concentrations of aflatoxin biomarkers among employees of Universiti Putra Malaysia
title_short	Effect of supplementation of fermented milk drink containing probiotic Lactobacillus casei Shirota on the concentrations of aflatoxin biomarkers among employees of Universiti Putra Malaysia
title_full	Effect of supplementation of fermented milk drink containing probiotic Lactobacillus casei Shirota on the concentrations of aflatoxin biomarkers among employees of Universiti Putra Malaysia
title_fullStr	Effect of supplementation of fermented milk drink containing probiotic Lactobacillus casei Shirota on the concentrations of aflatoxin biomarkers among employees of Universiti Putra Malaysia
title_full_unstemmed	Effect of supplementation of fermented milk drink containing probiotic Lactobacillus casei Shirota on the concentrations of aflatoxin biomarkers among employees of Universiti Putra Malaysia
title_sort	effect of supplementation of fermented milk drink containing probiotic lactobacillus casei shirota on the concentrations of aflatoxin biomarkers among employees of universiti putra malaysia
publisher	Cambridge University Press
publishDate	2016
url	http://psasir.upm.edu.my/id/eprint/54055/1/Effect%20of%20supplementation%20of%20fermented%20milk%20drink%20containing%20probiotic%20Lactobacillus%20.pdf http://psasir.upm.edu.my/id/eprint/54055/ https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/effect-of-supplementation-of-fermented-milk-drink-containing-probiotic-lactobacillus-casei-shirota-on-the-concentrations-of-aflatoxin-biomarkers-among-employees-of-universiti-put
_version_	1643835553056030720
score	13.211869

Effect of supplementation of fermented milk drink containing probiotic Lactobacillus casei Shirota on the concentrations of aflatoxin biomarkers among employees of Universiti Putra Malaysia

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