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Validation of a modified algometer to measure mechanical nociceptive thresholds in awake dogs

This study was conducted to validate the use of a modified algometer device to measure mechanical nociceptive thresholds in six dogs. Dogs were administered morphine intravenously (IV) at 1 mg/kg or saline at equivolume in a crossover design with one-week washout period. Mechanical nociceptive thres...

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Main Authors: Kaka, Ubedullah, Chen, Hui Cheng, Goh, Yong Meng, Abdul Abubakar, Adamu, Fakurazi, Sharida, Ebrahimi, Mahdi
Format: Article
Language:English
Published: Hindawi 2015
Online Access:http://psasir.upm.edu.my/id/eprint/46846/1/Validation%20of%20a%20modified%20algometer%20to%20measure%20mechanical%20nociceptive%20thresholds%20in%20awake%20dogs.pdf
http://psasir.upm.edu.my/id/eprint/46846/
https://www.hindawi.com/journals/bmri/2015/375421/
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spelling my.upm.eprints.468462022-05-25T03:54:18Z http://psasir.upm.edu.my/id/eprint/46846/ Validation of a modified algometer to measure mechanical nociceptive thresholds in awake dogs Kaka, Ubedullah Chen, Hui Cheng Goh, Yong Meng Abdul Abubakar, Adamu Fakurazi, Sharida Ebrahimi, Mahdi This study was conducted to validate the use of a modified algometer device to measure mechanical nociceptive thresholds in six dogs. Dogs were administered morphine intravenously (IV) at 1 mg/kg or saline at equivolume in a crossover design with one-week washout period. Mechanical nociceptive thresholds were determined before, after the administration of treatments at 5 minutes, and hourly for 8 hours. Thresholds were recorded at the carpal pad, metacarpal foot pad, tibia, femur, and abdomen. Heart rates, body temperature, and respiration were recorded at similar time points. Thresholds increased significantly () from baseline values for up to 3 hours at tibia and abdomen, 4 hours at metacarpal pad, and 5 hours at the carpal pad and femur. Hypothermia, bradycardia, and change in respiration were observed in all dogs after morphine injection. Saline did not alter any threshold levels during the eight-hour study period, indicating no evidence of tolerance, learned avoidance, or local hyperaesthesia. The device and methods of testing were well tolerated by all the dogs. Results suggest that the modified algometer and method of application are useful to measure nociceptive mechanical thresholds in awake dogs. Hindawi 2015 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/46846/1/Validation%20of%20a%20modified%20algometer%20to%20measure%20mechanical%20nociceptive%20thresholds%20in%20awake%20dogs.pdf Kaka, Ubedullah and Chen, Hui Cheng and Goh, Yong Meng and Abdul Abubakar, Adamu and Fakurazi, Sharida and Ebrahimi, Mahdi (2015) Validation of a modified algometer to measure mechanical nociceptive thresholds in awake dogs. BIOMED RESEARCH INTERNATIONAL, 2015. art. no. 375421. pp. 1-7. ISSN 2314-6133; ESSN: 2314-6141 https://www.hindawi.com/journals/bmri/2015/375421/ 10.1155/2015/375421
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description This study was conducted to validate the use of a modified algometer device to measure mechanical nociceptive thresholds in six dogs. Dogs were administered morphine intravenously (IV) at 1 mg/kg or saline at equivolume in a crossover design with one-week washout period. Mechanical nociceptive thresholds were determined before, after the administration of treatments at 5 minutes, and hourly for 8 hours. Thresholds were recorded at the carpal pad, metacarpal foot pad, tibia, femur, and abdomen. Heart rates, body temperature, and respiration were recorded at similar time points. Thresholds increased significantly () from baseline values for up to 3 hours at tibia and abdomen, 4 hours at metacarpal pad, and 5 hours at the carpal pad and femur. Hypothermia, bradycardia, and change in respiration were observed in all dogs after morphine injection. Saline did not alter any threshold levels during the eight-hour study period, indicating no evidence of tolerance, learned avoidance, or local hyperaesthesia. The device and methods of testing were well tolerated by all the dogs. Results suggest that the modified algometer and method of application are useful to measure nociceptive mechanical thresholds in awake dogs.
format Article
author Kaka, Ubedullah
Chen, Hui Cheng
Goh, Yong Meng
Abdul Abubakar, Adamu
Fakurazi, Sharida
Ebrahimi, Mahdi
spellingShingle Kaka, Ubedullah
Chen, Hui Cheng
Goh, Yong Meng
Abdul Abubakar, Adamu
Fakurazi, Sharida
Ebrahimi, Mahdi
Validation of a modified algometer to measure mechanical nociceptive thresholds in awake dogs
author_facet Kaka, Ubedullah
Chen, Hui Cheng
Goh, Yong Meng
Abdul Abubakar, Adamu
Fakurazi, Sharida
Ebrahimi, Mahdi
author_sort Kaka, Ubedullah
title Validation of a modified algometer to measure mechanical nociceptive thresholds in awake dogs
title_short Validation of a modified algometer to measure mechanical nociceptive thresholds in awake dogs
title_full Validation of a modified algometer to measure mechanical nociceptive thresholds in awake dogs
title_fullStr Validation of a modified algometer to measure mechanical nociceptive thresholds in awake dogs
title_full_unstemmed Validation of a modified algometer to measure mechanical nociceptive thresholds in awake dogs
title_sort validation of a modified algometer to measure mechanical nociceptive thresholds in awake dogs
publisher Hindawi
publishDate 2015
url http://psasir.upm.edu.my/id/eprint/46846/1/Validation%20of%20a%20modified%20algometer%20to%20measure%20mechanical%20nociceptive%20thresholds%20in%20awake%20dogs.pdf
http://psasir.upm.edu.my/id/eprint/46846/
https://www.hindawi.com/journals/bmri/2015/375421/
_version_ 1734301569649737728
score 13.211869

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