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Gallic acid attenuates dextran sulfate sodium- induced experimental colitis in BALB/c mice

Gallic acid (GA) is a polyhydroxy phenolic compound that has been detected in various natural products, such as green tea, strawberries, grapes, bananas, and many other fruits. In inflammatory bowel disease, inflammation is promoted by oxidative stress. GA is a strong antioxidant; thus, we evaluated...

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Main Authors: Pandurangan, Ashok Kumar, Mohebali, Nooshin, Mohd Esa, Norhaizan, Chung, Yeng Looi
Format: Article
Language:English
Published: Dove Medical Press 2015
Online Access:http://psasir.upm.edu.my/id/eprint/44869/1/DEXT.pdf
http://psasir.upm.edu.my/id/eprint/44869/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4524530/
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spelling my.upm.eprints.448692021-02-28T17:53:38Z http://psasir.upm.edu.my/id/eprint/44869/ Gallic acid attenuates dextran sulfate sodium- induced experimental colitis in BALB/c mice Pandurangan, Ashok Kumar Mohebali, Nooshin Mohd Esa, Norhaizan Chung, Yeng Looi Gallic acid (GA) is a polyhydroxy phenolic compound that has been detected in various natural products, such as green tea, strawberries, grapes, bananas, and many other fruits. In inflammatory bowel disease, inflammation is promoted by oxidative stress. GA is a strong antioxidant; thus, we evaluated the cytoprotective and anti-inflammatory role of GA in a dextran sulfate sodium (DSS)-induced mouse colitis model. Experimental acute colitis was induced in male BALB/c mice by administering 2.5% DSS in the drinking water for 7 days. The disease activity index; colon weight/length ratio; histopathological analysis; mRNA expressions of IL-21 and IL-23; and protein expression of nuclear erythroid 2-related factor 2 (Nrf2) were compared between the control and experimental mice. The colonic content of malondialdehyde and the activities of superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase activity were examined as parameters of the redox state. We determined that GA significantly attenuated the disease activity index and colon shortening, and reduced the histopathological evidence of injury. GA also significantly (P<0.05) reduced the expressions of IL-21 and IL-23. Furthermore, GA activates/upregulates the expression of Nrf2 and its downstream targets, including UDP-GT and NQO1, in DSS-induced mice. The findings of this study demonstrate the protective effect of GA on experimental colitis, which is probably due to an antioxidant nature of GA. Dove Medical Press 2015 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/44869/1/DEXT.pdf Pandurangan, Ashok Kumar and Mohebali, Nooshin and Mohd Esa, Norhaizan and Chung, Yeng Looi (2015) Gallic acid attenuates dextran sulfate sodium- induced experimental colitis in BALB/c mice. Drug Design Development and Therapy, 2015 (9). pp. 3923-3934. ISSN 1177-8881 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4524530/
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Gallic acid (GA) is a polyhydroxy phenolic compound that has been detected in various natural products, such as green tea, strawberries, grapes, bananas, and many other fruits. In inflammatory bowel disease, inflammation is promoted by oxidative stress. GA is a strong antioxidant; thus, we evaluated the cytoprotective and anti-inflammatory role of GA in a dextran sulfate sodium (DSS)-induced mouse colitis model. Experimental acute colitis was induced in male BALB/c mice by administering 2.5% DSS in the drinking water for 7 days. The disease activity index; colon weight/length ratio; histopathological analysis; mRNA expressions of IL-21 and IL-23; and protein expression of nuclear erythroid 2-related factor 2 (Nrf2) were compared between the control and experimental mice. The colonic content of malondialdehyde and the activities of superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase activity were examined as parameters of the redox state. We determined that GA significantly attenuated the disease activity index and colon shortening, and reduced the histopathological evidence of injury. GA also significantly (P<0.05) reduced the expressions of IL-21 and IL-23. Furthermore, GA activates/upregulates the expression of Nrf2 and its downstream targets, including UDP-GT and NQO1, in DSS-induced mice. The findings of this study demonstrate the protective effect of GA on experimental colitis, which is probably due to an antioxidant nature of GA.
format Article
author Pandurangan, Ashok Kumar
Mohebali, Nooshin
Mohd Esa, Norhaizan
Chung, Yeng Looi
spellingShingle Pandurangan, Ashok Kumar
Mohebali, Nooshin
Mohd Esa, Norhaizan
Chung, Yeng Looi
Gallic acid attenuates dextran sulfate sodium- induced experimental colitis in BALB/c mice
author_facet Pandurangan, Ashok Kumar
Mohebali, Nooshin
Mohd Esa, Norhaizan
Chung, Yeng Looi
author_sort Pandurangan, Ashok Kumar
title Gallic acid attenuates dextran sulfate sodium- induced experimental colitis in BALB/c mice
title_short Gallic acid attenuates dextran sulfate sodium- induced experimental colitis in BALB/c mice
title_full Gallic acid attenuates dextran sulfate sodium- induced experimental colitis in BALB/c mice
title_fullStr Gallic acid attenuates dextran sulfate sodium- induced experimental colitis in BALB/c mice
title_full_unstemmed Gallic acid attenuates dextran sulfate sodium- induced experimental colitis in BALB/c mice
title_sort gallic acid attenuates dextran sulfate sodium- induced experimental colitis in balb/c mice
publisher Dove Medical Press
publishDate 2015
url http://psasir.upm.edu.my/id/eprint/44869/1/DEXT.pdf
http://psasir.upm.edu.my/id/eprint/44869/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4524530/
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score 13.211869

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