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Allicin alleviates Dextran Sodium Sulfate (DSS)-induced ulcerative colitis in BALB/c mice

The objective of this study is to evaluate the effect of allicin (10mg/kg body weight, orally) in an experimental murine model of UC by administering 2.5% dextran sodium sulfate (DSS) in drinking water to BALB/c mice. DSS-induced mice presented reduced body weight, which was improved by allicin admi...

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Main Authors: Pandurangan, Ashok Kumar, Ismail, Salmiah, Saadatdoust, Zeinab, Mohd Esa, Norhaizan
Format: Article
Language:English
Published: Hindawi Publishing Corporation 2015
Online Access:http://psasir.upm.edu.my/id/eprint/43689/1/Allicin%20Alleviates%20Dextran%20Sodium.pdf
http://psasir.upm.edu.my/id/eprint/43689/
http://www.hindawi.com/journals/omcl/2015/605208/
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spelling my.upm.eprints.436892016-08-08T09:13:47Z http://psasir.upm.edu.my/id/eprint/43689/ Allicin alleviates Dextran Sodium Sulfate (DSS)-induced ulcerative colitis in BALB/c mice Pandurangan, Ashok Kumar Ismail, Salmiah Saadatdoust, Zeinab Mohd Esa, Norhaizan The objective of this study is to evaluate the effect of allicin (10mg/kg body weight, orally) in an experimental murine model of UC by administering 2.5% dextran sodium sulfate (DSS) in drinking water to BALB/c mice. DSS-induced mice presented reduced body weight, which was improved by allicin administration. We noted increases in CD68 expression, myeloperoxidase (MPO) activities, and Malonaldehyde (MDA) and mRNA levels of proinflammatory cytokines, such as tumor necrosis factor- (TNF-) Hindawi Publishing Corporation 2015 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/43689/1/Allicin%20Alleviates%20Dextran%20Sodium.pdf Pandurangan, Ashok Kumar and Ismail, Salmiah and Saadatdoust, Zeinab and Mohd Esa, Norhaizan (2015) Allicin alleviates Dextran Sodium Sulfate (DSS)-induced ulcerative colitis in BALB/c mice. Oxidative Medicine and Cellular Longevity, 2015. art. no. 60520. pp. 1-13. ISSN 1942-0900; ESSN: 1942-0994 http://www.hindawi.com/journals/omcl/2015/605208/ 10.1155/2015/605208
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description The objective of this study is to evaluate the effect of allicin (10mg/kg body weight, orally) in an experimental murine model of UC by administering 2.5% dextran sodium sulfate (DSS) in drinking water to BALB/c mice. DSS-induced mice presented reduced body weight, which was improved by allicin administration. We noted increases in CD68 expression, myeloperoxidase (MPO) activities, and Malonaldehyde (MDA) and mRNA levels of proinflammatory cytokines, such as tumor necrosis factor- (TNF-)
format Article
author Pandurangan, Ashok Kumar
Ismail, Salmiah
Saadatdoust, Zeinab
Mohd Esa, Norhaizan
spellingShingle Pandurangan, Ashok Kumar
Ismail, Salmiah
Saadatdoust, Zeinab
Mohd Esa, Norhaizan
Allicin alleviates Dextran Sodium Sulfate (DSS)-induced ulcerative colitis in BALB/c mice
author_facet Pandurangan, Ashok Kumar
Ismail, Salmiah
Saadatdoust, Zeinab
Mohd Esa, Norhaizan
author_sort Pandurangan, Ashok Kumar
title Allicin alleviates Dextran Sodium Sulfate (DSS)-induced ulcerative colitis in BALB/c mice
title_short Allicin alleviates Dextran Sodium Sulfate (DSS)-induced ulcerative colitis in BALB/c mice
title_full Allicin alleviates Dextran Sodium Sulfate (DSS)-induced ulcerative colitis in BALB/c mice
title_fullStr Allicin alleviates Dextran Sodium Sulfate (DSS)-induced ulcerative colitis in BALB/c mice
title_full_unstemmed Allicin alleviates Dextran Sodium Sulfate (DSS)-induced ulcerative colitis in BALB/c mice
title_sort allicin alleviates dextran sodium sulfate (dss)-induced ulcerative colitis in balb/c mice
publisher Hindawi Publishing Corporation
publishDate 2015
url http://psasir.upm.edu.my/id/eprint/43689/1/Allicin%20Alleviates%20Dextran%20Sodium.pdf
http://psasir.upm.edu.my/id/eprint/43689/
http://www.hindawi.com/journals/omcl/2015/605208/
_version_ 1643833639891369984
score 13.211869

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