Neuroprotective potential of secondary metabolites from Melicope lunu-ankenda (Rutaceae)

Plant natural compounds have great potential as alternative medicines for preventing and treating diseases. Melicope lunu-ankenda is one Melicope species (family Rutaceae), which is widely used in traditional medicine, consumed as a salad and a food seasoning. Consumption of different parts of this...

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Bibliographic Details
Main Authors: Mohamed, Zeinab Abdulwanis, Eliaser, Enas Mohamed, Mazzon, Emanuela, Rollin, Patrick, Ee, Gwendoline Cheng Lian, Abdull Razis, Ahmad Faizal
Format: Article
Language:English
Published: MDPI 2019
Online Access:http://psasir.upm.edu.my/id/eprint/38283/1/38283.pdf
http://psasir.upm.edu.my/id/eprint/38283/
https://www.mdpi.com/1420-3049/24/17/3109
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Summary:Plant natural compounds have great potential as alternative medicines for preventing and treating diseases. Melicope lunu-ankenda is one Melicope species (family Rutaceae), which is widely used in traditional medicine, consumed as a salad and a food seasoning. Consumption of different parts of this plant has been reported to exert different biological activities such as antioxidant and anti-inflammatory qualities, resulting in a protective effect against several health disorders including neurodegenerative diseases. Various secondary metabolites such as phenolic acid derivatives, flavonoids, coumarins and alkaloids, isolated from the M. lunu-ankenda plant, were demonstrated to have neuroprotective activities and also exert many other beneficial biological effects. A number of studies have revealed different neuroprotective mechanisms for these secondary metabolites. This review summarizes the most significant and recent studies for neuroprotective activity of M. lunu-ankenda major secondary metabolites in neurodegenerative diseases.