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Effects of saffron extract and crocin on anthropometrical, nutritional and lipid profile parameters of rats fed a high fat diet

Overweight and obesity are the most common nutritional disorders in the world. The aim of this study was to evaluate anti-obesity effects of ethanolic extracts of saffron and crocin in comparison to orlistat in animal model. Male Sprague Dawley (SD) rats were fed high-fat diet (HFD) for 12 weeks to...

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Main Authors: Mashmoul, Maryam, Azlan, Azrina, Mohd Yusof, Barakatun Nisak, Khaza'aid, Huzwah, Mohtarrudin, Norhafizah, Boroushaki, Mohammad Taher
Format: Article
Language:English
Published: Elsevier 2014
Online Access:http://psasir.upm.edu.my/id/eprint/37390/1/Effects%20of%20saffron%20extract%20and%20crocin%20on%20anthropometrical.pdf
http://psasir.upm.edu.my/id/eprint/37390/
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spelling my.upm.eprints.373902015-10-06T03:40:25Z http://psasir.upm.edu.my/id/eprint/37390/ Effects of saffron extract and crocin on anthropometrical, nutritional and lipid profile parameters of rats fed a high fat diet Mashmoul, Maryam Azlan, Azrina Mohd Yusof, Barakatun Nisak Khaza'aid, Huzwah Mohtarrudin, Norhafizah Boroushaki, Mohammad Taher Overweight and obesity are the most common nutritional disorders in the world. The aim of this study was to evaluate anti-obesity effects of ethanolic extracts of saffron and crocin in comparison to orlistat in animal model. Male Sprague Dawley (SD) rats were fed high-fat diet (HFD) for 12 weeks to induce obesity. The saffron extracts (40 and 80 mg/kg), crocin (40 and 80 mg/kg) and orlistat (20 mg/kg) were fed to rats by mixing with high fat diet (HFD) for 8 weeks. Changes in anthropometrical, nutritional and lipid profile parameters were measured. The saffron extract significantly decreased food consumption in obese rats. Crocin (80 mg/kg) showed a significant decrease on rate of body weight gain, total fat pad and weight ratio of epididymal fat to body. Furthermore, crocin (80 mg/kg) significantly reduced plasma levels of triacylglycerol (TG) and total cholesterol (TC) while saffron extract (40 mg/kg) showed major improvement in low-density lipoprotein to high-density lipoprotein (LDL/HDL) level as atherogenic index. These findings demonstrated the potential anti-obesity benefits of saffron extract and crocin in preclinical study. Elsevier 2014-05 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/37390/1/Effects%20of%20saffron%20extract%20and%20crocin%20on%20anthropometrical.pdf Mashmoul, Maryam and Azlan, Azrina and Mohd Yusof, Barakatun Nisak and Khaza'aid, Huzwah and Mohtarrudin, Norhafizah and Boroushaki, Mohammad Taher (2014) Effects of saffron extract and crocin on anthropometrical, nutritional and lipid profile parameters of rats fed a high fat diet. Journal of Functional Foods, 8. pp. 180-187. ISSN 1756-4646; ESSN: 2214-9414 10.1016/j.jff.2014.03.017
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Overweight and obesity are the most common nutritional disorders in the world. The aim of this study was to evaluate anti-obesity effects of ethanolic extracts of saffron and crocin in comparison to orlistat in animal model. Male Sprague Dawley (SD) rats were fed high-fat diet (HFD) for 12 weeks to induce obesity. The saffron extracts (40 and 80 mg/kg), crocin (40 and 80 mg/kg) and orlistat (20 mg/kg) were fed to rats by mixing with high fat diet (HFD) for 8 weeks. Changes in anthropometrical, nutritional and lipid profile parameters were measured. The saffron extract significantly decreased food consumption in obese rats. Crocin (80 mg/kg) showed a significant decrease on rate of body weight gain, total fat pad and weight ratio of epididymal fat to body. Furthermore, crocin (80 mg/kg) significantly reduced plasma levels of triacylglycerol (TG) and total cholesterol (TC) while saffron extract (40 mg/kg) showed major improvement in low-density lipoprotein to high-density lipoprotein (LDL/HDL) level as atherogenic index. These findings demonstrated the potential anti-obesity benefits of saffron extract and crocin in preclinical study.
format Article
author Mashmoul, Maryam
Azlan, Azrina
Mohd Yusof, Barakatun Nisak
Khaza'aid, Huzwah
Mohtarrudin, Norhafizah
Boroushaki, Mohammad Taher
spellingShingle Mashmoul, Maryam
Azlan, Azrina
Mohd Yusof, Barakatun Nisak
Khaza'aid, Huzwah
Mohtarrudin, Norhafizah
Boroushaki, Mohammad Taher
Effects of saffron extract and crocin on anthropometrical, nutritional and lipid profile parameters of rats fed a high fat diet
author_facet Mashmoul, Maryam
Azlan, Azrina
Mohd Yusof, Barakatun Nisak
Khaza'aid, Huzwah
Mohtarrudin, Norhafizah
Boroushaki, Mohammad Taher
author_sort Mashmoul, Maryam
title Effects of saffron extract and crocin on anthropometrical, nutritional and lipid profile parameters of rats fed a high fat diet
title_short Effects of saffron extract and crocin on anthropometrical, nutritional and lipid profile parameters of rats fed a high fat diet
title_full Effects of saffron extract and crocin on anthropometrical, nutritional and lipid profile parameters of rats fed a high fat diet
title_fullStr Effects of saffron extract and crocin on anthropometrical, nutritional and lipid profile parameters of rats fed a high fat diet
title_full_unstemmed Effects of saffron extract and crocin on anthropometrical, nutritional and lipid profile parameters of rats fed a high fat diet
title_sort effects of saffron extract and crocin on anthropometrical, nutritional and lipid profile parameters of rats fed a high fat diet
publisher Elsevier
publishDate 2014
url http://psasir.upm.edu.my/id/eprint/37390/1/Effects%20of%20saffron%20extract%20and%20crocin%20on%20anthropometrical.pdf
http://psasir.upm.edu.my/id/eprint/37390/
_version_ 1643831975163723776
score 13.211869

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