Pathogenic Gram-positive bacteria are highly sensitive to triphenylphosphanegold(O-alkylthiocarbamates), Ph3PAu[SC(OR)=N(p-tolyl)] (R = Me, Et and iPr)
The phosphanegold(I) thiocarbamides, Ph3PAu{SC(OR)=NC6H4Me-4} for R = Me (1), Et (2) and iPr (3), have been shown to have essentially linear gold atom coordination geometries defined by phosphane-P and thiolate-S atoms, and exhibit minimum inhibitory concentration (MIC) values in the range of 1–37 μ...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Springer
2013
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| Online Access: | http://psasir.upm.edu.my/id/eprint/29592/1/Pathogenic%20Gram-positive%20bacteria%20are%20highly%20sensitive%20to%20triphenylphosphanegold%28O-alkylthiocarbamates%29%2C%20Ph3PAu%5BSC%28OR%29%3DN%28p-tolyl%29%5D%20%28R%E2%80%89%3D%E2%80%89Me%2C%20Et%20and%20iPr%29.pdf http://psasir.upm.edu.my/id/eprint/29592/ http://link.springer.com/article/10.1007/s13404-013-0091-z?view=classic |
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| Summary: | The phosphanegold(I) thiocarbamides, Ph3PAu{SC(OR)=NC6H4Me-4} for R = Me (1), Et (2) and iPr (3), have been shown to have essentially linear gold atom coordination geometries defined by phosphane-P and thiolate-S atoms, and exhibit minimum inhibitory concentration (MIC) values in the range of 1–37 μg/ml against four Gram-positive bacteria, namely Bacillus cereus, Enterococcus faecalis, Enterococcus faecium and Staphylococcus aureus; compounds 1–3 are less potent against a broad panel of 16 Gram-negative bacteria. As the minimum bactericidal concentration values were quite similar to the MIC values, compounds 1–3 are effective bactericidal agents. The specific action against the four Gram-positive bacteria suggests they function by inhibition of peptidoglycan synthesis. |
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