Pathogenic Gram-positive bacteria are highly sensitive to triphenylphosphanegold(O-alkylthiocarbamates), Ph3PAu[SC(OR)=N(p-tolyl)] (R = Me, Et and iPr)

The phosphanegold(I) thiocarbamides, Ph3PAu{SC(OR)=NC6H4Me-4} for R = Me (1), Et (2) and iPr (3), have been shown to have essentially linear gold atom coordination geometries defined by phosphane-P and thiolate-S atoms, and exhibit minimum inhibitory concentration (MIC) values in the range of 1–37 μ...

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主要な著者: Yeo, Chien Ing, Sim, Jiun Horng, Khoo, Chai Hoon, Goh, Zheng Jie, Ang, Kok Pian, Cheah, Yoke Kqueen, Fairuz, Zainal Abidin, Abdul Halim, Siti Nadiah, Ng, Seik Weng, Seng, Hoi Ling, Tiekink, Edward R. T.
フォーマット: 論文
言語:English
出版事項: Springer 2013
オンライン・アクセス:http://psasir.upm.edu.my/id/eprint/29592/1/Pathogenic%20Gram-positive%20bacteria%20are%20highly%20sensitive%20to%20triphenylphosphanegold%28O-alkylthiocarbamates%29%2C%20Ph3PAu%5BSC%28OR%29%3DN%28p-tolyl%29%5D%20%28R%E2%80%89%3D%E2%80%89Me%2C%20Et%20and%20iPr%29.pdf
http://psasir.upm.edu.my/id/eprint/29592/
http://link.springer.com/article/10.1007/s13404-013-0091-z?view=classic
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要約:The phosphanegold(I) thiocarbamides, Ph3PAu{SC(OR)=NC6H4Me-4} for R = Me (1), Et (2) and iPr (3), have been shown to have essentially linear gold atom coordination geometries defined by phosphane-P and thiolate-S atoms, and exhibit minimum inhibitory concentration (MIC) values in the range of 1–37 μg/ml against four Gram-positive bacteria, namely Bacillus cereus, Enterococcus faecalis, Enterococcus faecium and Staphylococcus aureus; compounds 1–3 are less potent against a broad panel of 16 Gram-negative bacteria. As the minimum bactericidal concentration values were quite similar to the MIC values, compounds 1–3 are effective bactericidal agents. The specific action against the four Gram-positive bacteria suggests they function by inhibition of peptidoglycan synthesis.