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Influence of electron irradiation factor on haruan traditional extract (HTE) for oral drug delivery

Haruan or Channa striatus is source of protein that is widely consumed in the region and its extract is well known for having medical values. It is of great advantage if this product could be taken orally rather than by injection because the oral route of drug delivery is still preferred by the vast...

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Main Authors: Ijang, Ibrahim, Mat Jais, Abdul Manan, H., Kamaruddin
Format: Article
Language:English
Published: Malaysian Nuclear Agency 2014
Online Access:http://psasir.upm.edu.my/id/eprint/12805/1/Influence%20of%20electron%20irradiation%20factor%20on%20haruan%20traditional%20extract%20%28HTE%29%20for%20oral%20drug%20delivery.pdf
http://psasir.upm.edu.my/id/eprint/12805/
https://jsnm.nuclearmalaysia.gov.my/index.php/jsnm/article/view/94
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spelling my.upm.eprints.128052018-06-11T08:35:27Z http://psasir.upm.edu.my/id/eprint/12805/ Influence of electron irradiation factor on haruan traditional extract (HTE) for oral drug delivery Ijang, Ibrahim Mat Jais, Abdul Manan H., Kamaruddin Haruan or Channa striatus is source of protein that is widely consumed in the region and its extract is well known for having medical values. It is of great advantage if this product could be taken orally rather than by injection because the oral route of drug delivery is still preferred by the vast majority of patients. However protein and peptides can be denatured or degraded by the acidic pH of the stomach and the presence of endogenous enzymes. In order to protect or prevent digestion and degradation of the protein in the stomach and to ensure the protein reaches the gastro intestinal (GI) tract, Carboxymethyl Starch (CMS) nanogel system was developed using electron irradiation method. However stability of HTE during the irradiation process needed to be studied before being developed further. In this study, the HTE was irradiated using electron beams. Its stability was analysed in terms of physical and chemical changes by looking at colour difference, melting point by using Differential Scanning Calorimetry (DSC) and molecular bonds by using Fourier Transform Infrared (FTIR) respectively. The results of this study were that no apparent colour difference was observed with HTE before and after irradiation. These observations were supported by the FTIR and DSC results that showed that there were no changes in molecular bonds and melting point, compared between no irradiation and irradiation HTE during electron irradiation up to 10 kGy. Statistically the test showed no significant difference at p < 0.005 between melting temperatures. Malaysian Nuclear Agency 2014 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/12805/1/Influence%20of%20electron%20irradiation%20factor%20on%20haruan%20traditional%20extract%20%28HTE%29%20for%20oral%20drug%20delivery.pdf Ijang, Ibrahim and Mat Jais, Abdul Manan and H., Kamaruddin (2014) Influence of electron irradiation factor on haruan traditional extract (HTE) for oral drug delivery. Jurnal Sains Nuklear Malaysia, 26 (1). pp. 1-8. ISSN 2232-0946 https://jsnm.nuclearmalaysia.gov.my/index.php/jsnm/article/view/94
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Haruan or Channa striatus is source of protein that is widely consumed in the region and its extract is well known for having medical values. It is of great advantage if this product could be taken orally rather than by injection because the oral route of drug delivery is still preferred by the vast majority of patients. However protein and peptides can be denatured or degraded by the acidic pH of the stomach and the presence of endogenous enzymes. In order to protect or prevent digestion and degradation of the protein in the stomach and to ensure the protein reaches the gastro intestinal (GI) tract, Carboxymethyl Starch (CMS) nanogel system was developed using electron irradiation method. However stability of HTE during the irradiation process needed to be studied before being developed further. In this study, the HTE was irradiated using electron beams. Its stability was analysed in terms of physical and chemical changes by looking at colour difference, melting point by using Differential Scanning Calorimetry (DSC) and molecular bonds by using Fourier Transform Infrared (FTIR) respectively. The results of this study were that no apparent colour difference was observed with HTE before and after irradiation. These observations were supported by the FTIR and DSC results that showed that there were no changes in molecular bonds and melting point, compared between no irradiation and irradiation HTE during electron irradiation up to 10 kGy. Statistically the test showed no significant difference at p < 0.005 between melting temperatures.
format Article
author Ijang, Ibrahim
Mat Jais, Abdul Manan
H., Kamaruddin
spellingShingle Ijang, Ibrahim
Mat Jais, Abdul Manan
H., Kamaruddin
Influence of electron irradiation factor on haruan traditional extract (HTE) for oral drug delivery
author_facet Ijang, Ibrahim
Mat Jais, Abdul Manan
H., Kamaruddin
author_sort Ijang, Ibrahim
title Influence of electron irradiation factor on haruan traditional extract (HTE) for oral drug delivery
title_short Influence of electron irradiation factor on haruan traditional extract (HTE) for oral drug delivery
title_full Influence of electron irradiation factor on haruan traditional extract (HTE) for oral drug delivery
title_fullStr Influence of electron irradiation factor on haruan traditional extract (HTE) for oral drug delivery
title_full_unstemmed Influence of electron irradiation factor on haruan traditional extract (HTE) for oral drug delivery
title_sort influence of electron irradiation factor on haruan traditional extract (hte) for oral drug delivery
publisher Malaysian Nuclear Agency
publishDate 2014
url http://psasir.upm.edu.my/id/eprint/12805/1/Influence%20of%20electron%20irradiation%20factor%20on%20haruan%20traditional%20extract%20%28HTE%29%20for%20oral%20drug%20delivery.pdf
http://psasir.upm.edu.my/id/eprint/12805/
https://jsnm.nuclearmalaysia.gov.my/index.php/jsnm/article/view/94
_version_ 1643825139912015872
score 13.211869

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