Candida glabrata gene expression response upon engulfment by THP-1 macrophages
Candida glabeuta has emerged as a significant pathogen, particularly in immunocompromised individuals. It exhibits a unique capability to persist within macrophages, thereby prolonging the infection. This study investigates the alteration of ICLI and MNN2 gene expression in engulfed C glabrata durin...
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| Main Authors: | , |
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| Format: | Conference or Workshop Item |
| Language: | English |
| Published: |
2024
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| Online Access: | http://psasir.upm.edu.my/id/eprint/115493/1/115493.jpg http://psasir.upm.edu.my/id/eprint/115493/ |
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| Summary: | Candida glabeuta has emerged as a significant pathogen, particularly in immunocompromised individuals. It exhibits a unique capability to persist within macrophages, thereby prolonging the infection. This study investigates the alteration of ICLI and MNN2 gene expression in engulfed C glabrata during macrophage interaction to understand its adaptive strategies against the host immune system, specifically focusing on genes linked to altered metabolism and cell wall modifications. The rise in multidrug-resistant C. globroto strains limits treatment options, necessitating a congrefensive understanding of its gone functions and interactions. |
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