Oxidative Dna Damage In Leukocytes And Its Association With Metabolic Control In Diabetic Patients With And Without Microalbuminuria
Type 2 diabetes mellitus is the predominant type of diabetes mellitus and the type likely to go undiagnosed. Oxidative damage was suggested in the development of diabetic microangiopathic and macroangiopathic complications in these patients. Since the long-term complications are the main cause o...
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| Main Author: | |
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| Format: | Thesis |
| Language: | English English |
| Published: |
2001
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| Online Access: | http://psasir.upm.edu.my/id/eprint/11220/1/FPSK_M_2001_8_.pdf http://psasir.upm.edu.my/id/eprint/11220/ |
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| Summary: | Type 2 diabetes mellitus is the predominant type of diabetes mellitus
and the type likely to go undiagnosed. Oxidative damage was suggested in
the development of diabetic microangiopathic and macroangiopathic
complications in these patients. Since the long-term complications are the
main cause of morbidity and mortality in diabetic patients, a quantitative
determination of the level of oxidative stress is a valuable indicator of the
degree of the severity of the disease and of the effectiveness of treatment.
The main aim of this study is to evaluate the extent of oxidative DNA damage
with different severity of microalbuminuria in diabetic patients and its
associations with other metabolic controls. The comet assay was adopted to
measure the level of oxidative DNA damage in leukocytes. One hundred and
twenty seven (127) Type 2 diabetic patients with- and without
microalbuminuria were recruited from the Outpatients Department and |
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