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Effect of Rosa Roxburghii juice on starch digestibility: a focus on the binding of polyphenols to amylose and porcine pancreatic α-amylase by molecular modeling

Chestnut rose (Rosa Roxburghii) is an endemic fruit in China with many bioactivities. The present study investigated the effect of chestnut rose juice concentrate (CRJC) on the digestibility of normal wheat starch (NWS), with a focus on the interaction between polyphenols and amylose as well as that...

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Main Authors: Zhu, Jianzhong, Zhang, Bin, Tan, Chin Ping, Ding, Li, Shao, Miao, Chen, Chun, Fu, Xiong, Huang, Qiang
Format: Article
Published: Elsevier 2022
Online Access:http://psasir.upm.edu.my/id/eprint/101138/
https://www.sciencedirect.com/science/article/pii/S0268005X21003829
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spelling my.upm.eprints.1011382023-05-23T02:55:50Z http://psasir.upm.edu.my/id/eprint/101138/ Effect of Rosa Roxburghii juice on starch digestibility: a focus on the binding of polyphenols to amylose and porcine pancreatic α-amylase by molecular modeling Zhu, Jianzhong Zhang, Bin Tan, Chin Ping Ding, Li Shao, Miao Chen, Chun Fu, Xiong Huang, Qiang Chestnut rose (Rosa Roxburghii) is an endemic fruit in China with many bioactivities. The present study investigated the effect of chestnut rose juice concentrate (CRJC) on the digestibility of normal wheat starch (NWS), with a focus on the interaction between polyphenols and amylose as well as that between polyphenols and porcine pancreatic α-amylase (PPA). NWS was mixed with CRJC and digestibility was determined using Englyst method. The composition of CRJC was analyzed by ultrahigh performance liquid chromatography-mass spectrometry. Molecular dynamics (MD) was used to study the binding between polyphenols and PPA and between polyphenols and amylose. The results showed that CRJC could significantly increase the resistant starch content. The MD results agreed with previous docking and experimental results regarding the inhibitory effects (IEs) of polyphenols (with galloyl and glycosyl group differences) against α-glucosidase. The MD results also showed that complex polyphenols with greater molecular weights or a high number of hydrogen bond donors (HBDs)/acceptors (HBAs) bind in a stronger and more lasting manner with amylose than simple polyphenols. CRJC has the potential to reduce the risk of developing type 2 diabetes and molecular simulation can be a supporting tool to study mechanisms in food system. Elsevier 2022-02 Article PeerReviewed Zhu, Jianzhong and Zhang, Bin and Tan, Chin Ping and Ding, Li and Shao, Miao and Chen, Chun and Fu, Xiong and Huang, Qiang (2022) Effect of Rosa Roxburghii juice on starch digestibility: a focus on the binding of polyphenols to amylose and porcine pancreatic α-amylase by molecular modeling. Food Hydrocolloids, 123. art. no. 106966. pp. 1-9. ISSN 0268-005X https://www.sciencedirect.com/science/article/pii/S0268005X21003829 10.1016/j.foodhyd.2021.106966
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
description Chestnut rose (Rosa Roxburghii) is an endemic fruit in China with many bioactivities. The present study investigated the effect of chestnut rose juice concentrate (CRJC) on the digestibility of normal wheat starch (NWS), with a focus on the interaction between polyphenols and amylose as well as that between polyphenols and porcine pancreatic α-amylase (PPA). NWS was mixed with CRJC and digestibility was determined using Englyst method. The composition of CRJC was analyzed by ultrahigh performance liquid chromatography-mass spectrometry. Molecular dynamics (MD) was used to study the binding between polyphenols and PPA and between polyphenols and amylose. The results showed that CRJC could significantly increase the resistant starch content. The MD results agreed with previous docking and experimental results regarding the inhibitory effects (IEs) of polyphenols (with galloyl and glycosyl group differences) against α-glucosidase. The MD results also showed that complex polyphenols with greater molecular weights or a high number of hydrogen bond donors (HBDs)/acceptors (HBAs) bind in a stronger and more lasting manner with amylose than simple polyphenols. CRJC has the potential to reduce the risk of developing type 2 diabetes and molecular simulation can be a supporting tool to study mechanisms in food system.
format Article
author Zhu, Jianzhong
Zhang, Bin
Tan, Chin Ping
Ding, Li
Shao, Miao
Chen, Chun
Fu, Xiong
Huang, Qiang
spellingShingle Zhu, Jianzhong
Zhang, Bin
Tan, Chin Ping
Ding, Li
Shao, Miao
Chen, Chun
Fu, Xiong
Huang, Qiang
Effect of Rosa Roxburghii juice on starch digestibility: a focus on the binding of polyphenols to amylose and porcine pancreatic α-amylase by molecular modeling
author_facet Zhu, Jianzhong
Zhang, Bin
Tan, Chin Ping
Ding, Li
Shao, Miao
Chen, Chun
Fu, Xiong
Huang, Qiang
author_sort Zhu, Jianzhong
title Effect of Rosa Roxburghii juice on starch digestibility: a focus on the binding of polyphenols to amylose and porcine pancreatic α-amylase by molecular modeling
title_short Effect of Rosa Roxburghii juice on starch digestibility: a focus on the binding of polyphenols to amylose and porcine pancreatic α-amylase by molecular modeling
title_full Effect of Rosa Roxburghii juice on starch digestibility: a focus on the binding of polyphenols to amylose and porcine pancreatic α-amylase by molecular modeling
title_fullStr Effect of Rosa Roxburghii juice on starch digestibility: a focus on the binding of polyphenols to amylose and porcine pancreatic α-amylase by molecular modeling
title_full_unstemmed Effect of Rosa Roxburghii juice on starch digestibility: a focus on the binding of polyphenols to amylose and porcine pancreatic α-amylase by molecular modeling
title_sort effect of rosa roxburghii juice on starch digestibility: a focus on the binding of polyphenols to amylose and porcine pancreatic α-amylase by molecular modeling
publisher Elsevier
publishDate 2022
url http://psasir.upm.edu.my/id/eprint/101138/
https://www.sciencedirect.com/science/article/pii/S0268005X21003829
_version_ 1768009439787352064
score 13.211869

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