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Discovery of azetidine based ene-amides as potent bacterial enoyl ACP reductase (FabI) inhibitors

A novel and potent series of ene-amides featuring azetidines has been developed as FabI inhibitors active against drug resistant Gram-positive pathogens particularly staphylococcal organisms. Most of the compounds from the series possessed excellent biochemical inhibition of Staphylococcus aureus Fa...

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Bibliographic Details
Main Authors: Takhi, M., Sreenivas, K., Reddy, C.K., Munikumar, M., Praveena, K., Sudheer, P., Rao, B.N.V.M., Ramakanth, G., Sivaranjani, J., Mulik, S., Reddy, Y.R., Narasimha Rao, K., Pallavi, R., Lakshminarasimhan, A., Panigrahi, S.K., Antony, T., Abdullah, I., Lee, Y.K., Ramachandra, M., Yusof, R., Rahman, N.A., Subramanya, H.
Format: Article
Language:English
Published: 2017
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