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Disability after encephalitis : development and validation of a new outcome score.

Objective : To develop a simple tool for assessing the severity of disability resulting from Japanese encephalitis and whether, as a result, a child is likely to be dependent. Methods : A new outcome score based on a 15-item questionnaire was developed after a literature review, examination of cu...

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Main Authors:	Lewthwaite, Penny, Begum, Ashia, Ooi, Mong How, Faragher, Brian, Lai, Boon Foo, Sandaradura, Indunil, Mohan, Anand, Mandhan, Gaurav, Meharwade, Pratibha, Subhashini, S, Abhishek, Gulia, Begum, Asma, Penkulinti, Srihari, Shankar, M Veera, Ravikumar, R, Young, Carolyn, Cardosa, Mary Jane, Ravi, V, Wong, See Chang, Kneen, Rachel, Solomon, Tom
Format:	Article
Language:	English
Published:	Research 2010
Subjects:	Q Science (General) QR355 Virology R Medicine (General)
Online Access:	http://ir.unimas.my/id/eprint/7009/1/Disability%20after.pdf http://ir.unimas.my/id/eprint/7009/ http://www.ncbi.nlm.nih.gov/pubmed/?term=20680123
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id	my.unimas.ir.7009
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spelling	my.unimas.ir.70092022-03-18T08:36:43Z http://ir.unimas.my/id/eprint/7009/ Disability after encephalitis : development and validation of a new outcome score. Lewthwaite, Penny Begum, Ashia Ooi, Mong How Faragher, Brian Lai, Boon Foo Sandaradura, Indunil Mohan, Anand Mandhan, Gaurav Meharwade, Pratibha Subhashini, S Abhishek, Gulia Begum, Asma Penkulinti, Srihari Shankar, M Veera Ravikumar, R Young, Carolyn Cardosa, Mary Jane Ravi, V Wong, See Chang Kneen, Rachel Solomon, Tom Q Science (General) QR355 Virology R Medicine (General) Objective : To develop a simple tool for assessing the severity of disability resulting from Japanese encephalitis and whether, as a result, a child is likely to be dependent. Methods : A new outcome score based on a 15-item questionnaire was developed after a literature review, examination of current assessment tools, discussion with experts and a pilot study. The score was used to evaluate 100 children in Malaysia (56 Japanese encephalitis patients, 2 patients with encephalitis of unknown etiology and 42 controls) and 95 in India (36 Japanese encephalitis patients, 41 patients with encephalitis of unknown etiology and 18 controls). Inter- and intra-observer variability in the outcome score was determined and the score was compared with full clinical assessment. Findings: There was good inter-observer agreement on using the new score to identify likely dependency (Κ=0.942 for Malaysian children; Κ=0.786 for Indian children) and good intra-observer agreement (Κ=1.000 and 0.902, respectively). In addition, agreement between the new score and clinical assessment was also good (Κ=0.906 and 0.762, respectively). The sensitivity and specificity of the new score for identifying children likely to be dependent were 100% and 98.4% in Malaysia and 100% and 93.8% in India. Positive and negative predictive values were 84.2% and 100% in Malaysia and 65.6% and 100% in India. Conclusion The new tool for assessing disability in children after Japanese encephalitis was simple to use and scores correlated well with clinical assessment. Research 2010-04-19 Article PeerReviewed text en http://ir.unimas.my/id/eprint/7009/1/Disability%20after.pdf Lewthwaite, Penny and Begum, Ashia and Ooi, Mong How and Faragher, Brian and Lai, Boon Foo and Sandaradura, Indunil and Mohan, Anand and Mandhan, Gaurav and Meharwade, Pratibha and Subhashini, S and Abhishek, Gulia and Begum, Asma and Penkulinti, Srihari and Shankar, M Veera and Ravikumar, R and Young, Carolyn and Cardosa, Mary Jane and Ravi, V and Wong, See Chang and Kneen, Rachel and Solomon, Tom (2010) Disability after encephalitis : development and validation of a new outcome score. Bull World Health Organ, 88 (8). pp. 584-592. ISSN 0042-9686 http://www.ncbi.nlm.nih.gov/pubmed/?term=20680123 doi:10.2471/BLT.09.071357
institution	Universiti Malaysia Sarawak
building	Centre for Academic Information Services (CAIS)
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaysia Sarawak
content_source	UNIMAS Institutional Repository
url_provider	http://ir.unimas.my/
language	English
topic	Q Science (General) QR355 Virology R Medicine (General)
spellingShingle	Q Science (General) QR355 Virology R Medicine (General) Lewthwaite, Penny Begum, Ashia Ooi, Mong How Faragher, Brian Lai, Boon Foo Sandaradura, Indunil Mohan, Anand Mandhan, Gaurav Meharwade, Pratibha Subhashini, S Abhishek, Gulia Begum, Asma Penkulinti, Srihari Shankar, M Veera Ravikumar, R Young, Carolyn Cardosa, Mary Jane Ravi, V Wong, See Chang Kneen, Rachel Solomon, Tom Disability after encephalitis : development and validation of a new outcome score.
description	Objective : To develop a simple tool for assessing the severity of disability resulting from Japanese encephalitis and whether, as a result, a child is likely to be dependent. Methods : A new outcome score based on a 15-item questionnaire was developed after a literature review, examination of current assessment tools, discussion with experts and a pilot study. The score was used to evaluate 100 children in Malaysia (56 Japanese encephalitis patients, 2 patients with encephalitis of unknown etiology and 42 controls) and 95 in India (36 Japanese encephalitis patients, 41 patients with encephalitis of unknown etiology and 18 controls). Inter- and intra-observer variability in the outcome score was determined and the score was compared with full clinical assessment. Findings: There was good inter-observer agreement on using the new score to identify likely dependency (Κ=0.942 for Malaysian children; Κ=0.786 for Indian children) and good intra-observer agreement (Κ=1.000 and 0.902, respectively). In addition, agreement between the new score and clinical assessment was also good (Κ=0.906 and 0.762, respectively). The sensitivity and specificity of the new score for identifying children likely to be dependent were 100% and 98.4% in Malaysia and 100% and 93.8% in India. Positive and negative predictive values were 84.2% and 100% in Malaysia and 65.6% and 100% in India. Conclusion The new tool for assessing disability in children after Japanese encephalitis was simple to use and scores correlated well with clinical assessment.
format	Article
author	Lewthwaite, Penny Begum, Ashia Ooi, Mong How Faragher, Brian Lai, Boon Foo Sandaradura, Indunil Mohan, Anand Mandhan, Gaurav Meharwade, Pratibha Subhashini, S Abhishek, Gulia Begum, Asma Penkulinti, Srihari Shankar, M Veera Ravikumar, R Young, Carolyn Cardosa, Mary Jane Ravi, V Wong, See Chang Kneen, Rachel Solomon, Tom
author_facet	Lewthwaite, Penny Begum, Ashia Ooi, Mong How Faragher, Brian Lai, Boon Foo Sandaradura, Indunil Mohan, Anand Mandhan, Gaurav Meharwade, Pratibha Subhashini, S Abhishek, Gulia Begum, Asma Penkulinti, Srihari Shankar, M Veera Ravikumar, R Young, Carolyn Cardosa, Mary Jane Ravi, V Wong, See Chang Kneen, Rachel Solomon, Tom
author_sort	Lewthwaite, Penny
title	Disability after encephalitis : development and validation of a new outcome score.
title_short	Disability after encephalitis : development and validation of a new outcome score.
title_full	Disability after encephalitis : development and validation of a new outcome score.
title_fullStr	Disability after encephalitis : development and validation of a new outcome score.
title_full_unstemmed	Disability after encephalitis : development and validation of a new outcome score.
title_sort	disability after encephalitis : development and validation of a new outcome score.
publisher	Research
publishDate	2010
url	http://ir.unimas.my/id/eprint/7009/1/Disability%20after.pdf http://ir.unimas.my/id/eprint/7009/ http://www.ncbi.nlm.nih.gov/pubmed/?term=20680123
_version_	1728055582016929792
score	13.211869

Disability after encephalitis : development and validation of a new outcome score.

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