Disability after encephalitis : development and validation of a new outcome score.
Objective : To develop a simple tool for assessing the severity of disability resulting from Japanese encephalitis and whether, as a result, a child is likely to be dependent. Methods : A new outcome score based on a 15-item questionnaire was developed after a literature review, examination of cu...
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| 主要な著者: | , , , , , , , , , , , , , , , , , , , , |
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| フォーマット: | 論文 |
| 言語: | English |
| 出版事項: |
Research
2010
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| 主題: | |
| オンライン･アクセス: | http://ir.unimas.my/id/eprint/7009/1/Disability%20after.pdf http://ir.unimas.my/id/eprint/7009/ http://www.ncbi.nlm.nih.gov/pubmed/?term=20680123 |
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| 要約: | Objective : To develop a simple tool for assessing the severity of disability resulting from Japanese encephalitis and whether, as a result, a child is likely to be dependent.
Methods : A new outcome score based on a 15-item questionnaire was developed after a literature review, examination of current
assessment tools, discussion with experts and a pilot study. The score was used to evaluate 100 children in Malaysia (56 Japanese encephalitis patients, 2 patients with encephalitis of unknown etiology and 42 controls) and 95 in India (36 Japanese encephalitis patients, 41 patients with encephalitis of unknown etiology and 18 controls). Inter- and intra-observer variability in the outcome score was determined and the score was compared with full clinical assessment.
Findings: There was good inter-observer agreement on using the new score to identify likely dependency (Κ=0.942 for Malaysian
children; Κ=0.786 for Indian children) and good intra-observer agreement (Κ=1.000 and 0.902, respectively). In addition, agreement between the new score and clinical assessment was also good (Κ=0.906 and 0.762, respectively). The sensitivity and specificity of the new score for identifying children likely to be dependent were 100% and 98.4% in Malaysia and 100% and 93.8% in India. Positive and negative predictive values were 84.2% and 100% in Malaysia and 65.6% and 100% in India.
Conclusion The new tool for assessing disability in children after Japanese encephalitis was simple to use and scores correlated well with clinical assessment. |
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