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Letter to the Editor : Sylvatic Dengue Viruses Share the Pathogenic Potential of Urban/Endemic Dengue Viruses

Dengue virus (DENV) exists in both sylvatic and urban/endemic ecotypes (15), and the potential for emergence of sylvatic strains has become a focus of research. Recently Mota and Rico-Hesse (10) attempted to evaluate the pathogenic potential of viruses belonging to different genetic subgroups of DEN...

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Main Authors: Vasilakis, Nikos, Cardosa, Mary Jane, Sall, Amadou A., Diallo, Mawlouth, Holmes, Edward C., Hanley, Kathryn A., Weaver, Scott C.
Format: E-Article
Language:English
Published: American Society for Microbiology 2010
Subjects:
Q Science (General)
QR355 Virology
R Medicine (General)
Online Access:http://ir.unimas.my/id/eprint/6976/1/Sylvatic%20Dengue%20Viruses%20Share%20the%20Pathogenic%20Potential%20of%20Urban%20Endemic%20Dengue%20Viruses%20%28abstract%29.pdf
http://ir.unimas.my/id/eprint/6976/
http://jvi.asm.org/content/84/7/3726.full.pdf+html
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spelling my.unimas.ir.69762015-04-10T03:48:34Z http://ir.unimas.my/id/eprint/6976/ Letter to the Editor : Sylvatic Dengue Viruses Share the Pathogenic Potential of Urban/Endemic Dengue Viruses Vasilakis, Nikos Cardosa, Mary Jane Sall, Amadou A. Diallo, Mawlouth Holmes, Edward C. Hanley, Kathryn A. Weaver, Scott C. Q Science (General) QR355 Virology R Medicine (General) Dengue virus (DENV) exists in both sylvatic and urban/endemic ecotypes (15), and the potential for emergence of sylvatic strains has become a focus of research. Recently Mota and Rico-Hesse (10) attempted to evaluate the pathogenic potential of viruses belonging to different genetic subgroups of DENV serotype 2 (DENV-2). Based on the viremia levels and erythema index profiles of one sylvatic genotype and three (Asian, American, and Indian) urban/endemic genotypes evaluated using the NOD-scid IL2rγnull humanized mouse model, the authors concluded that sylvatic DENV-2 viruses possess a reduced pathogenic potential compared to strains belonging to urban/endemic DENV-2 genotypes. However, these conclusions ignore both patterns in their own data and a wealth of published ex vivo, in vivo, and epidemiological evidence collected over the past 40 years. American Society for Microbiology 2010-04 E-Article PeerReviewed text en http://ir.unimas.my/id/eprint/6976/1/Sylvatic%20Dengue%20Viruses%20Share%20the%20Pathogenic%20Potential%20of%20Urban%20Endemic%20Dengue%20Viruses%20%28abstract%29.pdf Vasilakis, Nikos and Cardosa, Mary Jane and Sall, Amadou A. and Diallo, Mawlouth and Holmes, Edward C. and Hanley, Kathryn A. and Weaver, Scott C. (2010) Letter to the Editor : Sylvatic Dengue Viruses Share the Pathogenic Potential of Urban/Endemic Dengue Viruses. Journal Of Virology, 84 (7). pp. 3726-3728. ISSN 0022-538X http://jvi.asm.org/content/84/7/3726.full.pdf+html
institution Universiti Malaysia Sarawak
building Centre for Academic Information Services (CAIS)
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sarawak
content_source UNIMAS Institutional Repository
url_provider http://ir.unimas.my/
language English
topic Q Science (General)
QR355 Virology
R Medicine (General)
spellingShingle Q Science (General)
QR355 Virology
R Medicine (General)
Vasilakis, Nikos
Cardosa, Mary Jane
Sall, Amadou A.
Diallo, Mawlouth
Holmes, Edward C.
Hanley, Kathryn A.
Weaver, Scott C.
Letter to the Editor : Sylvatic Dengue Viruses Share the Pathogenic Potential of Urban/Endemic Dengue Viruses
description Dengue virus (DENV) exists in both sylvatic and urban/endemic ecotypes (15), and the potential for emergence of sylvatic strains has become a focus of research. Recently Mota and Rico-Hesse (10) attempted to evaluate the pathogenic potential of viruses belonging to different genetic subgroups of DENV serotype 2 (DENV-2). Based on the viremia levels and erythema index profiles of one sylvatic genotype and three (Asian, American, and Indian) urban/endemic genotypes evaluated using the NOD-scid IL2rγnull humanized mouse model, the authors concluded that sylvatic DENV-2 viruses possess a reduced pathogenic potential compared to strains belonging to urban/endemic DENV-2 genotypes. However, these conclusions ignore both patterns in their own data and a wealth of published ex vivo, in vivo, and epidemiological evidence collected over the past 40 years.
format E-Article
author Vasilakis, Nikos
Cardosa, Mary Jane
Sall, Amadou A.
Diallo, Mawlouth
Holmes, Edward C.
Hanley, Kathryn A.
Weaver, Scott C.
author_facet Vasilakis, Nikos
Cardosa, Mary Jane
Sall, Amadou A.
Diallo, Mawlouth
Holmes, Edward C.
Hanley, Kathryn A.
Weaver, Scott C.
author_sort Vasilakis, Nikos
title Letter to the Editor : Sylvatic Dengue Viruses Share the Pathogenic Potential of Urban/Endemic Dengue Viruses
title_short Letter to the Editor : Sylvatic Dengue Viruses Share the Pathogenic Potential of Urban/Endemic Dengue Viruses
title_full Letter to the Editor : Sylvatic Dengue Viruses Share the Pathogenic Potential of Urban/Endemic Dengue Viruses
title_fullStr Letter to the Editor : Sylvatic Dengue Viruses Share the Pathogenic Potential of Urban/Endemic Dengue Viruses
title_full_unstemmed Letter to the Editor : Sylvatic Dengue Viruses Share the Pathogenic Potential of Urban/Endemic Dengue Viruses
title_sort letter to the editor : sylvatic dengue viruses share the pathogenic potential of urban/endemic dengue viruses
publisher American Society for Microbiology
publishDate 2010
url http://ir.unimas.my/id/eprint/6976/1/Sylvatic%20Dengue%20Viruses%20Share%20the%20Pathogenic%20Potential%20of%20Urban%20Endemic%20Dengue%20Viruses%20%28abstract%29.pdf
http://ir.unimas.my/id/eprint/6976/
http://jvi.asm.org/content/84/7/3726.full.pdf+html
_version_ 1644510185263202304
score 13.211869

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