Letter to the Editor : Sylvatic Dengue Viruses Share the Pathogenic Potential of Urban/Endemic Dengue Viruses

Dengue virus (DENV) exists in both sylvatic and urban/endemic ecotypes (15), and the potential for emergence of sylvatic strains has become a focus of research. Recently Mota and Rico-Hesse (10) attempted to evaluate the pathogenic potential of viruses belonging to different genetic subgroups of DEN...

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Bibliographic Details
Main Authors: Vasilakis, Nikos, Cardosa, Mary Jane, Sall, Amadou A., Diallo, Mawlouth, Holmes, Edward C., Hanley, Kathryn A., Weaver, Scott C.
Format: E-Article
Language:English
Published: American Society for Microbiology 2010
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Online Access:http://ir.unimas.my/id/eprint/6976/1/Sylvatic%20Dengue%20Viruses%20Share%20the%20Pathogenic%20Potential%20of%20Urban%20Endemic%20Dengue%20Viruses%20%28abstract%29.pdf
http://ir.unimas.my/id/eprint/6976/
http://jvi.asm.org/content/84/7/3726.full.pdf+html
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Summary:Dengue virus (DENV) exists in both sylvatic and urban/endemic ecotypes (15), and the potential for emergence of sylvatic strains has become a focus of research. Recently Mota and Rico-Hesse (10) attempted to evaluate the pathogenic potential of viruses belonging to different genetic subgroups of DENV serotype 2 (DENV-2). Based on the viremia levels and erythema index profiles of one sylvatic genotype and three (Asian, American, and Indian) urban/endemic genotypes evaluated using the NOD-scid IL2rγnull humanized mouse model, the authors concluded that sylvatic DENV-2 viruses possess a reduced pathogenic potential compared to strains belonging to urban/endemic DENV-2 genotypes. However, these conclusions ignore both patterns in their own data and a wealth of published ex vivo, in vivo, and epidemiological evidence collected over the past 40 years.