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Mapping human genetic diversity in Asia

Asia harbors substantial cultural and linguistic diversity, but the geographic structure of genetic variation across the continent remains enigmatic. Here we report a large-scale survey of autosomal variation from a broad geographic sample of Asian human populations. Our results show that genetic an...

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Main Authors:	MA, Abdulla, I, Ahmed, A, Assawamakin, J, Bhak, SK, Brahmachari, GC, Calacal, A, Chaurasia, CH, Chen, J, Chen, YT, Chen, J, Chu, EM, Cutiongco-de la Paz, MC, De Ungria, FC, Delfin, J, Edo, S, Fuchareon, H, Ghang, T, Gojobori, J, Han, SF, Ho, BP, Hoh, W, Huang, H, Inoko, P, Jha, Timothy Adrian, Jinam, L, Jin, J, Jung, D, Kangwanpong, J, Kampuansai, GC, Kennedy, P, Khurana, HL, Kim, K, Kim, S, Kim, WY, Kim, K, Kimm, R, Kimura, T, Koike, S, Kulawonganunchai, V, Kumar, PS, Lai, JY, Lee, S, Lee, ET, Liu, PP, Majumder, KK, Mandapati, S, Marzuki, W, Mitchell, M, Mukerji, K, Naritomi, C, Ngamphiw, N, Niikawa, N, Nishida, B, Oh, S, Oh, J, Ohashi, A, Oka, R, Ong, CD, Padilla, P, Palittapongarnpim, HB, Perdigon, Maude E., Phipps, E, Png, Y, Sakaki, JM, Salvador, Y, Sandraling, V, Scaria, M, Seielstad, MR, Sidek, A, Sinha, M, Srikummool, H, Sudoyo, S, Sugano, H, Suryadi, Y, Suzuki, KA, Tabbada, A, Tan, K, Tokunaga, S, Tongsima, LP, Villamor, E, Wang, Y, Wang, H, Wang, JY, Wu, H, Xiao, S, Xu, JO, Yang, YY, Shugart, HS, Yoo, W, Yuan, G, Zhao, BA, Zilfalil, Indian Genome Variation, Consortium
Format:	Article
Language:	English
Published:	American Association for the Advancement of Science. 2009
Subjects:	QH426 Genetics
Online Access:	http://ir.unimas.my/id/eprint/42230/1/science.1177074.pdf http://ir.unimas.my/id/eprint/42230/ https://www.science.org/doi/10.1126/science.1177074
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spelling	my.unimas.ir.422302023-07-12T03:47:27Z http://ir.unimas.my/id/eprint/42230/ Mapping human genetic diversity in Asia MA, Abdulla I, Ahmed A, Assawamakin J, Bhak SK, Brahmachari GC, Calacal A, Chaurasia CH, Chen J, Chen YT, Chen J, Chu EM, Cutiongco-de la Paz MC, De Ungria FC, Delfin J, Edo S, Fuchareon H, Ghang T, Gojobori J, Han SF, Ho BP, Hoh W, Huang H, Inoko P, Jha Timothy Adrian, Jinam L, Jin J, Jung D, Kangwanpong J, Kampuansai GC, Kennedy P, Khurana HL, Kim K, Kim S, Kim WY, Kim K, Kimm R, Kimura T, Koike S, Kulawonganunchai V, Kumar PS, Lai JY, Lee S, Lee ET, Liu PP, Majumder KK, Mandapati S, Marzuki W, Mitchell M, Mukerji K, Naritomi C, Ngamphiw N, Niikawa N, Nishida B, Oh S, Oh J, Ohashi A, Oka R, Ong CD, Padilla P, Palittapongarnpim HB, Perdigon Maude E., Phipps E, Png Y, Sakaki JM, Salvador Y, Sandraling V, Scaria M, Seielstad MR, Sidek A, Sinha M, Srikummool H, Sudoyo S, Sugano H, Suryadi Y, Suzuki KA, Tabbada A, Tan K, Tokunaga S, Tongsima LP, Villamor E, Wang Y, Wang H, Wang JY, Wu H, Xiao S, Xu JO, Yang YY, Shugart HS, Yoo W, Yuan G, Zhao BA, Zilfalil Indian Genome Variation, Consortium QH426 Genetics Asia harbors substantial cultural and linguistic diversity, but the geographic structure of genetic variation across the continent remains enigmatic. Here we report a large-scale survey of autosomal variation from a broad geographic sample of Asian human populations. Our results show that genetic ancestry is strongly correlated with linguistic affiliations as well as geography. Most populations show relatedness within ethnic/linguistic groups, despite prevalent gene flow among populations. More than 90% of East Asian (EA) haplotypes could be found in either Southeast Asian (SEA) or Central-South Asian (CSA) populations and show clinal structure with haplotype diversity decreasing from south to north. Furthermore, 50% of EA haplotypes were found in SEA only and 5% were found in CSA only, indicating that SEA was a major geographic source of EA populations. American Association for the Advancement of Science. 2009 Article PeerReviewed text en http://ir.unimas.my/id/eprint/42230/1/science.1177074.pdf MA, Abdulla and I, Ahmed and A, Assawamakin and J, Bhak and SK, Brahmachari and GC, Calacal and A, Chaurasia and CH, Chen and J, Chen and YT, Chen and J, Chu and EM, Cutiongco-de la Paz and MC, De Ungria and FC, Delfin and J, Edo and S, Fuchareon and H, Ghang and T, Gojobori and J, Han and SF, Ho and BP, Hoh and W, Huang and H, Inoko and P, Jha and Timothy Adrian, Jinam and L, Jin and J, Jung and D, Kangwanpong and J, Kampuansai and GC, Kennedy and P, Khurana and HL, Kim and K, Kim and S, Kim and WY, Kim and K, Kimm and R, Kimura and T, Koike and S, Kulawonganunchai and V, Kumar and PS, Lai and JY, Lee and S, Lee and ET, Liu and PP, Majumder and KK, Mandapati and S, Marzuki and W, Mitchell and M, Mukerji and K, Naritomi and C, Ngamphiw and N, Niikawa and N, Nishida and B, Oh and S, Oh and J, Ohashi and A, Oka and R, Ong and CD, Padilla and P, Palittapongarnpim and HB, Perdigon and Maude E., Phipps and E, Png and Y, Sakaki and JM, Salvador and Y, Sandraling and V, Scaria and M, Seielstad and MR, Sidek and A, Sinha and M, Srikummool and H, Sudoyo and S, Sugano and H, Suryadi and Y, Suzuki and KA, Tabbada and A, Tan and K, Tokunaga and S, Tongsima and LP, Villamor and E, Wang and Y, Wang and H, Wang and JY, Wu and H, Xiao and S, Xu and JO, Yang and YY, Shugart and HS, Yoo and W, Yuan and G, Zhao and BA, Zilfalil and Indian Genome Variation, Consortium (2009) Mapping human genetic diversity in Asia. Science, 326 (5959). pp. 1541-1545. ISSN 0036-8075 https://www.science.org/doi/10.1126/science.1177074 doi: 10.1126/science.1177074
institution	Universiti Malaysia Sarawak
building	Centre for Academic Information Services (CAIS)
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaysia Sarawak
content_source	UNIMAS Institutional Repository
url_provider	http://ir.unimas.my/
language	English
topic	QH426 Genetics
spellingShingle	QH426 Genetics MA, Abdulla I, Ahmed A, Assawamakin J, Bhak SK, Brahmachari GC, Calacal A, Chaurasia CH, Chen J, Chen YT, Chen J, Chu EM, Cutiongco-de la Paz MC, De Ungria FC, Delfin J, Edo S, Fuchareon H, Ghang T, Gojobori J, Han SF, Ho BP, Hoh W, Huang H, Inoko P, Jha Timothy Adrian, Jinam L, Jin J, Jung D, Kangwanpong J, Kampuansai GC, Kennedy P, Khurana HL, Kim K, Kim S, Kim WY, Kim K, Kimm R, Kimura T, Koike S, Kulawonganunchai V, Kumar PS, Lai JY, Lee S, Lee ET, Liu PP, Majumder KK, Mandapati S, Marzuki W, Mitchell M, Mukerji K, Naritomi C, Ngamphiw N, Niikawa N, Nishida B, Oh S, Oh J, Ohashi A, Oka R, Ong CD, Padilla P, Palittapongarnpim HB, Perdigon Maude E., Phipps E, Png Y, Sakaki JM, Salvador Y, Sandraling V, Scaria M, Seielstad MR, Sidek A, Sinha M, Srikummool H, Sudoyo S, Sugano H, Suryadi Y, Suzuki KA, Tabbada A, Tan K, Tokunaga S, Tongsima LP, Villamor E, Wang Y, Wang H, Wang JY, Wu H, Xiao S, Xu JO, Yang YY, Shugart HS, Yoo W, Yuan G, Zhao BA, Zilfalil Indian Genome Variation, Consortium Mapping human genetic diversity in Asia
description	Asia harbors substantial cultural and linguistic diversity, but the geographic structure of genetic variation across the continent remains enigmatic. Here we report a large-scale survey of autosomal variation from a broad geographic sample of Asian human populations. Our results show that genetic ancestry is strongly correlated with linguistic affiliations as well as geography. Most populations show relatedness within ethnic/linguistic groups, despite prevalent gene flow among populations. More than 90% of East Asian (EA) haplotypes could be found in either Southeast Asian (SEA) or Central-South Asian (CSA) populations and show clinal structure with haplotype diversity decreasing from south to north. Furthermore, 50% of EA haplotypes were found in SEA only and 5% were found in CSA only, indicating that SEA was a major geographic source of EA populations.
format	Article
author	MA, Abdulla I, Ahmed A, Assawamakin J, Bhak SK, Brahmachari GC, Calacal A, Chaurasia CH, Chen J, Chen YT, Chen J, Chu EM, Cutiongco-de la Paz MC, De Ungria FC, Delfin J, Edo S, Fuchareon H, Ghang T, Gojobori J, Han SF, Ho BP, Hoh W, Huang H, Inoko P, Jha Timothy Adrian, Jinam L, Jin J, Jung D, Kangwanpong J, Kampuansai GC, Kennedy P, Khurana HL, Kim K, Kim S, Kim WY, Kim K, Kimm R, Kimura T, Koike S, Kulawonganunchai V, Kumar PS, Lai JY, Lee S, Lee ET, Liu PP, Majumder KK, Mandapati S, Marzuki W, Mitchell M, Mukerji K, Naritomi C, Ngamphiw N, Niikawa N, Nishida B, Oh S, Oh J, Ohashi A, Oka R, Ong CD, Padilla P, Palittapongarnpim HB, Perdigon Maude E., Phipps E, Png Y, Sakaki JM, Salvador Y, Sandraling V, Scaria M, Seielstad MR, Sidek A, Sinha M, Srikummool H, Sudoyo S, Sugano H, Suryadi Y, Suzuki KA, Tabbada A, Tan K, Tokunaga S, Tongsima LP, Villamor E, Wang Y, Wang H, Wang JY, Wu H, Xiao S, Xu JO, Yang YY, Shugart HS, Yoo W, Yuan G, Zhao BA, Zilfalil Indian Genome Variation, Consortium
author_facet	MA, Abdulla I, Ahmed A, Assawamakin J, Bhak SK, Brahmachari GC, Calacal A, Chaurasia CH, Chen J, Chen YT, Chen J, Chu EM, Cutiongco-de la Paz MC, De Ungria FC, Delfin J, Edo S, Fuchareon H, Ghang T, Gojobori J, Han SF, Ho BP, Hoh W, Huang H, Inoko P, Jha Timothy Adrian, Jinam L, Jin J, Jung D, Kangwanpong J, Kampuansai GC, Kennedy P, Khurana HL, Kim K, Kim S, Kim WY, Kim K, Kimm R, Kimura T, Koike S, Kulawonganunchai V, Kumar PS, Lai JY, Lee S, Lee ET, Liu PP, Majumder KK, Mandapati S, Marzuki W, Mitchell M, Mukerji K, Naritomi C, Ngamphiw N, Niikawa N, Nishida B, Oh S, Oh J, Ohashi A, Oka R, Ong CD, Padilla P, Palittapongarnpim HB, Perdigon Maude E., Phipps E, Png Y, Sakaki JM, Salvador Y, Sandraling V, Scaria M, Seielstad MR, Sidek A, Sinha M, Srikummool H, Sudoyo S, Sugano H, Suryadi Y, Suzuki KA, Tabbada A, Tan K, Tokunaga S, Tongsima LP, Villamor E, Wang Y, Wang H, Wang JY, Wu H, Xiao S, Xu JO, Yang YY, Shugart HS, Yoo W, Yuan G, Zhao BA, Zilfalil Indian Genome Variation, Consortium
author_sort	MA, Abdulla
title	Mapping human genetic diversity in Asia
title_short	Mapping human genetic diversity in Asia
title_full	Mapping human genetic diversity in Asia
title_fullStr	Mapping human genetic diversity in Asia
title_full_unstemmed	Mapping human genetic diversity in Asia
title_sort	mapping human genetic diversity in asia
publisher	American Association for the Advancement of Science.
publishDate	2009
url	http://ir.unimas.my/id/eprint/42230/1/science.1177074.pdf http://ir.unimas.my/id/eprint/42230/ https://www.science.org/doi/10.1126/science.1177074
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score	13.211869

Mapping human genetic diversity in Asia

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