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Mapping human genetic diversity in Asia

Asia harbors substantial cultural and linguistic diversity, but the geographic structure of genetic variation across the continent remains enigmatic. Here we report a large-scale survey of autosomal variation from a broad geographic sample of Asian human populations. Our results show that genetic an...

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Main Authors: MA, Abdulla, I, Ahmed, A, Assawamakin, J, Bhak, SK, Brahmachari, GC, Calacal, A, Chaurasia, CH, Chen, J, Chen, YT, Chen, J, Chu, EM, Cutiongco-de la Paz, MC, De Ungria, FC, Delfin, J, Edo, S, Fuchareon, H, Ghang, T, Gojobori, J, Han, SF, Ho, BP, Hoh, W, Huang, H, Inoko, P, Jha, Timothy Adrian, Jinam, L, Jin, J, Jung, D, Kangwanpong, J, Kampuansai, GC, Kennedy, P, Khurana, HL, Kim, K, Kim, S, Kim, WY, Kim, K, Kimm, R, Kimura, T, Koike, S, Kulawonganunchai, V, Kumar, PS, Lai, JY, Lee, S, Lee, ET, Liu, PP, Majumder, KK, Mandapati, S, Marzuki, W, Mitchell, M, Mukerji, K, Naritomi, C, Ngamphiw, N, Niikawa, N, Nishida, B, Oh, S, Oh, J, Ohashi, A, Oka, R, Ong, CD, Padilla, P, Palittapongarnpim, HB, Perdigon, Maude E., Phipps, E, Png, Y, Sakaki, JM, Salvador, Y, Sandraling, V, Scaria, M, Seielstad, MR, Sidek, A, Sinha, M, Srikummool, H, Sudoyo, S, Sugano, H, Suryadi, Y, Suzuki, KA, Tabbada, A, Tan, K, Tokunaga, S, Tongsima, LP, Villamor, E, Wang, Y, Wang, H, Wang, JY, Wu, H, Xiao, S, Xu, JO, Yang, YY, Shugart, HS, Yoo, W, Yuan, G, Zhao, BA, Zilfalil, Indian Genome Variation, Consortium
格式: Article
语言:English
出版: American Association for the Advancement of Science. 2009
主题:
QH426 Genetics
在线阅读:http://ir.unimas.my/id/eprint/42230/1/science.1177074.pdf
http://ir.unimas.my/id/eprint/42230/
https://www.science.org/doi/10.1126/science.1177074
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总结:Asia harbors substantial cultural and linguistic diversity, but the geographic structure of genetic variation across the continent remains enigmatic. Here we report a large-scale survey of autosomal variation from a broad geographic sample of Asian human populations. Our results show that genetic ancestry is strongly correlated with linguistic affiliations as well as geography. Most populations show relatedness within ethnic/linguistic groups, despite prevalent gene flow among populations. More than 90% of East Asian (EA) haplotypes could be found in either Southeast Asian (SEA) or Central-South Asian (CSA) populations and show clinal structure with haplotype diversity decreasing from south to north. Furthermore, 50% of EA haplotypes were found in SEA only and 5% were found in CSA only, indicating that SEA was a major geographic source of EA populations.

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