Staff View: CONTRIBUTION TO THE PHYTOMEDICINAL STUDY OF THE SOLID AND AQUEOUS EXTRACT OF Anthurium schlechtendalii KUNTH ROOT AGAINST LIVER DAMAGE IN A RAT MODEL

CONTRIBUTION TO THE PHYTOMEDICINAL STUDY OF THE SOLID AND AQUEOUS EXTRACT OF Anthurium schlechtendalii KUNTH ROOT AGAINST LIVER DAMAGE IN A RAT MODEL

Plants have been used as a herbal treatment option for liver disease in alternative medicine. The current study was carried out to investigate the therapeutic potential of Anthurium schlechtendalii Kunth roots as a hepatoprotective or remission agent for liver damage. A preclinical study was carried...

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Main Authors:	Barradas, Dermitz, Dulce, maría, Nolasco-Hipolito, Cirilo, Hayward, Jones, Patricia, Margaret, Ramírez, Hemández Aurelio, Calderon, Garcidueñas, Ana, Laura, Olaide, Olawunmi Ajibola, Carvajal Zarrabal, Octavio
Format:	Article
Language:	English
Published:	SILAE - Societa Italo-Latinoamericana di Etnomedicina 2021
Subjects:	QD Chemistry QK Botany QR Microbiology QR355 Virology RM Therapeutics. Pharmacology RS Pharmacy and materia medica S Agriculture (General) TP Chemical technology
Online Access:	http://ir.unimas.my/id/eprint/37815/1/liver%20disease1.pdf http://ir.unimas.my/id/eprint/37815/ https://pharmacologyonline.silae.it/front/archives_2021_3
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spelling	my.unimas.ir.378152022-01-27T07:39:58Z http://ir.unimas.my/id/eprint/37815/ CONTRIBUTION TO THE PHYTOMEDICINAL STUDY OF THE SOLID AND AQUEOUS EXTRACT OF Anthurium schlechtendalii KUNTH ROOT AGAINST LIVER DAMAGE IN A RAT MODEL Barradas, Dermitz Dulce, maría Nolasco-Hipolito, Cirilo Hayward, Jones Patricia, Margaret Ramírez, Hemández Aurelio Calderon, Garcidueñas Ana, Laura Olaide, Olawunmi Ajibola Carvajal Zarrabal, Octavio QD Chemistry QK Botany QR Microbiology QR355 Virology RM Therapeutics. Pharmacology RS Pharmacy and materia medica S Agriculture (General) TP Chemical technology Plants have been used as a herbal treatment option for liver disease in alternative medicine. The current study was carried out to investigate the therapeutic potential of Anthurium schlechtendalii Kunth roots as a hepatoprotective or remission agent for liver damage. A preclinical study was carried out through oral administration of 4-tert-octylphenol (100 mg kg-1/day) as inducer of liver disease, and solid and aqueous extracts from the plant roots. The extracts were tested at doses of 125 mg kg-1/day and 1.8 mg mL-1/day, respectively, using a rat model in a 4-week experiment. Growth parameters (initial and final body weight, food intake, liquid consumption, liver weight) and liver function markers (aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) were determined. In addition, analysis of variance (one-way ANOVA) procedures, with a post hoc Tukey’s multiple range test for comparison of means (p <0.05), were performed. The study showed that, according to the lethal concentration (LC50) through the PROBIT transformation, the extract was nontoxic. The experimental model used, however, was not able to show liver function marker damage nor changes in growth parameters, so no statistically different results were found between the study groups (A, control; B, 4-tert-octylphenol; C, solid extract; D, solid and aqueous extracts; E, 4-tertoctylphenol plus solid extract; F, 4-tert-octylphenol plus solid and aqueous extracts). The method of toxic administration was not through direct oral dose but mixed in food, possibly producing a low intake of 4-tert-octylphenol thus not causing liver function marker damage. The need to continue and expand relevant research, to accumulate sufficient scientific knowledge and elucidate the efficacy of A.schlechtendalii Kunth roots in the prevention, mitigation, or remission of liver damage, has been made evident by the results obtained. SILAE - Societa Italo-Latinoamericana di Etnomedicina 2021-12-30 Article PeerReviewed text en http://ir.unimas.my/id/eprint/37815/1/liver%20disease1.pdf Barradas, Dermitz and Dulce, maría and Nolasco-Hipolito, Cirilo and Hayward, Jones and Patricia, Margaret and Ramírez, Hemández Aurelio and Calderon, Garcidueñas and Ana, Laura and Olaide, Olawunmi Ajibola and Carvajal Zarrabal, Octavio (2021) CONTRIBUTION TO THE PHYTOMEDICINAL STUDY OF THE SOLID AND AQUEOUS EXTRACT OF Anthurium schlechtendalii KUNTH ROOT AGAINST LIVER DAMAGE IN A RAT MODEL. PharmacologyOnline, 3 (2021). pp. 1283-1291. ISSN 1827-8620 https://pharmacologyonline.silae.it/front/archives_2021_3
institution	Universiti Malaysia Sarawak
building	Centre for Academic Information Services (CAIS)
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaysia Sarawak
content_source	UNIMAS Institutional Repository
url_provider	http://ir.unimas.my/
language	English
topic	QD Chemistry QK Botany QR Microbiology QR355 Virology RM Therapeutics. Pharmacology RS Pharmacy and materia medica S Agriculture (General) TP Chemical technology
spellingShingle	QD Chemistry QK Botany QR Microbiology QR355 Virology RM Therapeutics. Pharmacology RS Pharmacy and materia medica S Agriculture (General) TP Chemical technology Barradas, Dermitz Dulce, maría Nolasco-Hipolito, Cirilo Hayward, Jones Patricia, Margaret Ramírez, Hemández Aurelio Calderon, Garcidueñas Ana, Laura Olaide, Olawunmi Ajibola Carvajal Zarrabal, Octavio CONTRIBUTION TO THE PHYTOMEDICINAL STUDY OF THE SOLID AND AQUEOUS EXTRACT OF Anthurium schlechtendalii KUNTH ROOT AGAINST LIVER DAMAGE IN A RAT MODEL
description	Plants have been used as a herbal treatment option for liver disease in alternative medicine. The current study was carried out to investigate the therapeutic potential of Anthurium schlechtendalii Kunth roots as a hepatoprotective or remission agent for liver damage. A preclinical study was carried out through oral administration of 4-tert-octylphenol (100 mg kg-1/day) as inducer of liver disease, and solid and aqueous extracts from the plant roots. The extracts were tested at doses of 125 mg kg-1/day and 1.8 mg mL-1/day, respectively, using a rat model in a 4-week experiment. Growth parameters (initial and final body weight, food intake, liquid consumption, liver weight) and liver function markers (aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) were determined. In addition, analysis of variance (one-way ANOVA) procedures, with a post hoc Tukey’s multiple range test for comparison of means (p <0.05), were performed. The study showed that, according to the lethal concentration (LC50) through the PROBIT transformation, the extract was nontoxic. The experimental model used, however, was not able to show liver function marker damage nor changes in growth parameters, so no statistically different results were found between the study groups (A, control; B, 4-tert-octylphenol; C, solid extract; D, solid and aqueous extracts; E, 4-tertoctylphenol plus solid extract; F, 4-tert-octylphenol plus solid and aqueous extracts). The method of toxic administration was not through direct oral dose but mixed in food, possibly producing a low intake of 4-tert-octylphenol thus not causing liver function marker damage. The need to continue and expand relevant research, to accumulate sufficient scientific knowledge and elucidate the efficacy of A.schlechtendalii Kunth roots in the prevention, mitigation, or remission of liver damage, has been made evident by the results obtained.
format	Article
author	Barradas, Dermitz Dulce, maría Nolasco-Hipolito, Cirilo Hayward, Jones Patricia, Margaret Ramírez, Hemández Aurelio Calderon, Garcidueñas Ana, Laura Olaide, Olawunmi Ajibola Carvajal Zarrabal, Octavio
author_facet	Barradas, Dermitz Dulce, maría Nolasco-Hipolito, Cirilo Hayward, Jones Patricia, Margaret Ramírez, Hemández Aurelio Calderon, Garcidueñas Ana, Laura Olaide, Olawunmi Ajibola Carvajal Zarrabal, Octavio
author_sort	Barradas, Dermitz
title	CONTRIBUTION TO THE PHYTOMEDICINAL STUDY OF THE SOLID AND AQUEOUS EXTRACT OF Anthurium schlechtendalii KUNTH ROOT AGAINST LIVER DAMAGE IN A RAT MODEL
title_short	CONTRIBUTION TO THE PHYTOMEDICINAL STUDY OF THE SOLID AND AQUEOUS EXTRACT OF Anthurium schlechtendalii KUNTH ROOT AGAINST LIVER DAMAGE IN A RAT MODEL
title_full	CONTRIBUTION TO THE PHYTOMEDICINAL STUDY OF THE SOLID AND AQUEOUS EXTRACT OF Anthurium schlechtendalii KUNTH ROOT AGAINST LIVER DAMAGE IN A RAT MODEL
title_fullStr	CONTRIBUTION TO THE PHYTOMEDICINAL STUDY OF THE SOLID AND AQUEOUS EXTRACT OF Anthurium schlechtendalii KUNTH ROOT AGAINST LIVER DAMAGE IN A RAT MODEL
title_full_unstemmed	CONTRIBUTION TO THE PHYTOMEDICINAL STUDY OF THE SOLID AND AQUEOUS EXTRACT OF Anthurium schlechtendalii KUNTH ROOT AGAINST LIVER DAMAGE IN A RAT MODEL
title_sort	contribution to the phytomedicinal study of the solid and aqueous extract of anthurium schlechtendalii kunth root against liver damage in a rat model
publisher	SILAE - Societa Italo-Latinoamericana di Etnomedicina
publishDate	2021
url	http://ir.unimas.my/id/eprint/37815/1/liver%20disease1.pdf http://ir.unimas.my/id/eprint/37815/ https://pharmacologyonline.silae.it/front/archives_2021_3
_version_	1724078565704597504
score	13.211869

CONTRIBUTION TO THE PHYTOMEDICINAL STUDY OF THE SOLID AND AQUEOUS EXTRACT OF Anthurium schlechtendalii KUNTH ROOT AGAINST LIVER DAMAGE IN A RAT MODEL

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