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Comparison of Resting-State Brain Activation between Healthy Normal and Low Auditory-Verbal Working Memory Capacity Participants

Working memory (WM) capacity is the ability to maintain attention and store information briefly in the mind. However, each individual has a limited WM capacity that varies from one person to another. An individual can be categorized as having either normal or low WM capacity. This study aimed to...

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Main Authors: Nur Ruzainah, Gafoor, Ahmad Nazlim, Yusoff, Elza Azri, Othman, Nurul Hanim, Nasaruddin
Format: Article
Language:English
Published: Penerbit UTM Press 2021
Subjects:
Q Science (General)
QM Human anatomy
Online Access:http://ir.unimas.my/id/eprint/37623/1/healthy1.pdf
http://ir.unimas.my/id/eprint/37623/
https://mjfas.utm.my/index.php/mjfas/article/view/2186
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spelling my.unimas.ir.376232022-01-04T03:42:19Z http://ir.unimas.my/id/eprint/37623/ Comparison of Resting-State Brain Activation between Healthy Normal and Low Auditory-Verbal Working Memory Capacity Participants Nur Ruzainah, Gafoor Ahmad Nazlim, Yusoff Elza Azri, Othman Nurul Hanim, Nasaruddin Q Science (General) QM Human anatomy Working memory (WM) capacity is the ability to maintain attention and store information briefly in the mind. However, each individual has a limited WM capacity that varies from one person to another. An individual can be categorized as having either normal or low WM capacity. This study aimed to evaluate and compare brain activations of healthy individuals with low and normal auditory-verbal WM capacity. A total of 39 healthy male young adults were recruited from local universities for this study. They were categorized into the normal and low auditory-verbal WM capacity group based on their score in the Malay Version of Auditory Verbal Learning Test (MVAVLT). All participants underwent resting-state functional magnetic resonance imaging (rs-fMRI) scans. The functional data were analyzed using Statistical Parametric Mapping (SPM) and Wake Forest University (WFU) Pickatlas softwares. Brain activations and resting-state amplitude fluctuation (RsAF) were contrasted between groups to determine whether there were any significant differences caused by the different auditory-verbal WM capacity. The findings indicated that the low auditory-verbal WM capacity group showed significantly higher cortical activations in the left lingual gyrus, bilateral middle temporal gyrus, left calcarine, left superior frontal gyrus, and left precuneus as compared to normal auditory-verbal WM capacity group. It is suggested that the higher activation of these brain areas in low verbal-auditory WM capacity participants was attributed to the lower neural adaptability of the brain at rest. Penerbit UTM Press 2021-12-20 Article PeerReviewed text en http://ir.unimas.my/id/eprint/37623/1/healthy1.pdf Nur Ruzainah, Gafoor and Ahmad Nazlim, Yusoff and Elza Azri, Othman and Nurul Hanim, Nasaruddin (2021) Comparison of Resting-State Brain Activation between Healthy Normal and Low Auditory-Verbal Working Memory Capacity Participants. Malaysian Journal of Fundamental and Applied Sciences, 17 (6). pp. 678-688. ISSN 2289-5981 https://mjfas.utm.my/index.php/mjfas/article/view/2186
institution Universiti Malaysia Sarawak
building Centre for Academic Information Services (CAIS)
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sarawak
content_source UNIMAS Institutional Repository
url_provider http://ir.unimas.my/
language English
topic Q Science (General)
QM Human anatomy
spellingShingle Q Science (General)
QM Human anatomy
Nur Ruzainah, Gafoor
Ahmad Nazlim, Yusoff
Elza Azri, Othman
Nurul Hanim, Nasaruddin
Comparison of Resting-State Brain Activation between Healthy Normal and Low Auditory-Verbal Working Memory Capacity Participants
description Working memory (WM) capacity is the ability to maintain attention and store information briefly in the mind. However, each individual has a limited WM capacity that varies from one person to another. An individual can be categorized as having either normal or low WM capacity. This study aimed to evaluate and compare brain activations of healthy individuals with low and normal auditory-verbal WM capacity. A total of 39 healthy male young adults were recruited from local universities for this study. They were categorized into the normal and low auditory-verbal WM capacity group based on their score in the Malay Version of Auditory Verbal Learning Test (MVAVLT). All participants underwent resting-state functional magnetic resonance imaging (rs-fMRI) scans. The functional data were analyzed using Statistical Parametric Mapping (SPM) and Wake Forest University (WFU) Pickatlas softwares. Brain activations and resting-state amplitude fluctuation (RsAF) were contrasted between groups to determine whether there were any significant differences caused by the different auditory-verbal WM capacity. The findings indicated that the low auditory-verbal WM capacity group showed significantly higher cortical activations in the left lingual gyrus, bilateral middle temporal gyrus, left calcarine, left superior frontal gyrus, and left precuneus as compared to normal auditory-verbal WM capacity group. It is suggested that the higher activation of these brain areas in low verbal-auditory WM capacity participants was attributed to the lower neural adaptability of the brain at rest.
format Article
author Nur Ruzainah, Gafoor
Ahmad Nazlim, Yusoff
Elza Azri, Othman
Nurul Hanim, Nasaruddin
author_facet Nur Ruzainah, Gafoor
Ahmad Nazlim, Yusoff
Elza Azri, Othman
Nurul Hanim, Nasaruddin
author_sort Nur Ruzainah, Gafoor
title Comparison of Resting-State Brain Activation between Healthy Normal and Low Auditory-Verbal Working Memory Capacity Participants
title_short Comparison of Resting-State Brain Activation between Healthy Normal and Low Auditory-Verbal Working Memory Capacity Participants
title_full Comparison of Resting-State Brain Activation between Healthy Normal and Low Auditory-Verbal Working Memory Capacity Participants
title_fullStr Comparison of Resting-State Brain Activation between Healthy Normal and Low Auditory-Verbal Working Memory Capacity Participants
title_full_unstemmed Comparison of Resting-State Brain Activation between Healthy Normal and Low Auditory-Verbal Working Memory Capacity Participants
title_sort comparison of resting-state brain activation between healthy normal and low auditory-verbal working memory capacity participants
publisher Penerbit UTM Press
publishDate 2021
url http://ir.unimas.my/id/eprint/37623/1/healthy1.pdf
http://ir.unimas.my/id/eprint/37623/
https://mjfas.utm.my/index.php/mjfas/article/view/2186
_version_ 1724078541241319424
score 13.211869

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