Prognostic Value of Leucocyte Telomere Length in Acute Myocardial Infarction
Introduction: Leucocyte telomere length (LTL) has been described as a marker of biological age, endothelial dysfunction and atherosclerosis. The association between LTL and clinical characteristics of Asian patients, and their outcomes following acute myocardial infarction (AMI) have been inconclusi...
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2018
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| Online Access: | http://ir.unimas.my/id/eprint/22939/1/Leucocyte%20Telomere%20Length%20in%20Acute%20MI.pdf http://ir.unimas.my/id/eprint/22939/ https://www.journals.elsevier.com/international-journal-of-cardiology |
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my.unimas.ir.229392019-01-02T02:25:58Z http://ir.unimas.my/id/eprint/22939/ Prognostic Value of Leucocyte Telomere Length in Acute Myocardial Infarction Asri, Bin Said Ho, Kian Hui Jong, Siu Mei Fong, Alan Yean Yip Huang, Siaw San Syed Hazran, Bin Syed Mohammad Lee, James Zhi Yuan Chew, Rebecca Su Li Naemah, Binti Mazlan Koh, Keng Tat Shu, Francis Eng Pbeng Tan, Chen Ting Oon, Yen Yee Foo, Diana Hui Ping Nor Hanim, Binti Mohd Amin Cham, Yee Ling Khiew, Ning Zhan Voon, Chi Yen Ong, Tiong Kiam R Medicine (General) RC Internal medicine Introduction: Leucocyte telomere length (LTL) has been described as a marker of biological age, endothelial dysfunction and atherosclerosis. The association between LTL and clinical characteristics of Asian patients, and their outcomes following acute myocardial infarction (AMI) have been inconclusive. Objective: To investigate the relationship between LTL and developing AMI, the association of LTL with inpatient and 30-day mortality, and the comparison to LTL with established AMI risk scores in predicting these outcomes. Methodology: 100 patients aged 30-70 years admitted with an AMI to a tertiary referral center between May-Oct 2017 were enrolled; these were matched with 100 non-AMI ('healthy') controls for gender and age (+/- 1 year). Clinical data was obtained prospectively; inpatient and 30-day outcomes documented. LTL was reflected by a well described variable called a tis ratio (TSR). The TSR was measured at enrolment using a quantitative PCR-based methods (qPCR) and results blinded to the clinician. Elsevier 2018-12-15 E-Article NonPeerReviewed text en http://ir.unimas.my/id/eprint/22939/1/Leucocyte%20Telomere%20Length%20in%20Acute%20MI.pdf Asri, Bin Said and Ho, Kian Hui and Jong, Siu Mei and Fong, Alan Yean Yip and Huang, Siaw San and Syed Hazran, Bin Syed Mohammad and Lee, James Zhi Yuan and Chew, Rebecca Su Li and Naemah, Binti Mazlan and Koh, Keng Tat and Shu, Francis Eng Pbeng and Tan, Chen Ting and Oon, Yen Yee and Foo, Diana Hui Ping and Nor Hanim, Binti Mohd Amin and Cham, Yee Ling and Khiew, Ning Zhan and Voon, Chi Yen and Ong, Tiong Kiam (2018) Prognostic Value of Leucocyte Telomere Length in Acute Myocardial Infarction. International Journal of Cardiology, 273 (Supp). p. 3. ISSN 0167-5273 https://www.journals.elsevier.com/international-journal-of-cardiology DOI:10.1016/j.ijcard.2018.11.036 |
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R Medicine (General) RC Internal medicine Asri, Bin Said Ho, Kian Hui Jong, Siu Mei Fong, Alan Yean Yip Huang, Siaw San Syed Hazran, Bin Syed Mohammad Lee, James Zhi Yuan Chew, Rebecca Su Li Naemah, Binti Mazlan Koh, Keng Tat Shu, Francis Eng Pbeng Tan, Chen Ting Oon, Yen Yee Foo, Diana Hui Ping Nor Hanim, Binti Mohd Amin Cham, Yee Ling Khiew, Ning Zhan Voon, Chi Yen Ong, Tiong Kiam Prognostic Value of Leucocyte Telomere Length in Acute Myocardial Infarction |
| description |
Introduction: Leucocyte telomere length (LTL) has been described as a marker of biological age, endothelial dysfunction and atherosclerosis. The association between LTL and clinical characteristics of Asian patients, and their outcomes following acute myocardial infarction (AMI) have been inconclusive.
Objective: To investigate the relationship between LTL and developing AMI, the association of LTL with inpatient and 30-day mortality, and the comparison to LTL with established AMI risk scores in predicting these outcomes.
Methodology: 100 patients aged 30-70 years admitted with an AMI to a tertiary referral center between May-Oct 2017 were enrolled; these were matched with 100 non-AMI ('healthy') controls for gender and age (+/- 1 year). Clinical data was obtained prospectively; inpatient and 30-day outcomes documented. LTL was reflected by a well described variable called a tis ratio (TSR).
The TSR was measured at enrolment using a quantitative PCR-based methods (qPCR) and results blinded to the clinician. |
| format |
E-Article |
| author |
Asri, Bin Said Ho, Kian Hui Jong, Siu Mei Fong, Alan Yean Yip Huang, Siaw San Syed Hazran, Bin Syed Mohammad Lee, James Zhi Yuan Chew, Rebecca Su Li Naemah, Binti Mazlan Koh, Keng Tat Shu, Francis Eng Pbeng Tan, Chen Ting Oon, Yen Yee Foo, Diana Hui Ping Nor Hanim, Binti Mohd Amin Cham, Yee Ling Khiew, Ning Zhan Voon, Chi Yen Ong, Tiong Kiam |
| author_facet |
Asri, Bin Said Ho, Kian Hui Jong, Siu Mei Fong, Alan Yean Yip Huang, Siaw San Syed Hazran, Bin Syed Mohammad Lee, James Zhi Yuan Chew, Rebecca Su Li Naemah, Binti Mazlan Koh, Keng Tat Shu, Francis Eng Pbeng Tan, Chen Ting Oon, Yen Yee Foo, Diana Hui Ping Nor Hanim, Binti Mohd Amin Cham, Yee Ling Khiew, Ning Zhan Voon, Chi Yen Ong, Tiong Kiam |
| author_sort |
Asri, Bin Said |
| title |
Prognostic Value of Leucocyte Telomere Length in Acute Myocardial Infarction |
| title_short |
Prognostic Value of Leucocyte Telomere Length in Acute Myocardial Infarction |
| title_full |
Prognostic Value of Leucocyte Telomere Length in Acute Myocardial Infarction |
| title_fullStr |
Prognostic Value of Leucocyte Telomere Length in Acute Myocardial Infarction |
| title_full_unstemmed |
Prognostic Value of Leucocyte Telomere Length in Acute Myocardial Infarction |
| title_sort |
prognostic value of leucocyte telomere length in acute myocardial infarction |
| publisher |
Elsevier |
| publishDate |
2018 |
| url |
http://ir.unimas.my/id/eprint/22939/1/Leucocyte%20Telomere%20Length%20in%20Acute%20MI.pdf http://ir.unimas.my/id/eprint/22939/ https://www.journals.elsevier.com/international-journal-of-cardiology |
| _version_ |
1644513906827198464 |
| score |
13.211869 |