Prognostic Value of Leucocyte Telomere Length in Acute Myocardial Infarction
Introduction: Leucocyte telomere length (LTL) has been described as a marker of biological age, endothelial dysfunction and atherosclerosis. The association between LTL and clinical characteristics of Asian patients, and their outcomes following acute myocardial infarction (AMI) have been inconclusi...
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| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | E-Article |
| Language: | English |
| Published: |
Elsevier
2018
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| Subjects: | |
| Online Access: | http://ir.unimas.my/id/eprint/22939/1/Leucocyte%20Telomere%20Length%20in%20Acute%20MI.pdf http://ir.unimas.my/id/eprint/22939/ https://www.journals.elsevier.com/international-journal-of-cardiology |
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| Summary: | Introduction: Leucocyte telomere length (LTL) has been described as a marker of biological age, endothelial dysfunction and atherosclerosis. The association between LTL and clinical characteristics of Asian patients, and their outcomes following acute myocardial infarction (AMI) have been inconclusive.
Objective: To investigate the relationship between LTL and developing AMI, the association of LTL with inpatient and 30-day mortality, and the comparison to LTL with established AMI risk scores in predicting these outcomes.
Methodology: 100 patients aged 30-70 years admitted with an AMI to a tertiary referral center between May-Oct 2017 were enrolled; these were matched with 100 non-AMI ('healthy') controls for gender and age (+/- 1 year). Clinical data was obtained prospectively; inpatient and 30-day outcomes documented. LTL was reflected by a well described variable called a tis ratio (TSR).
The TSR was measured at enrolment using a quantitative PCR-based methods (qPCR) and results blinded to the clinician. |
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